A5006183237- Hepatitis B Virus Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Animal Virus Infections Studies
- Systemic Lupus Erythematosus Research
- Gut microbiota and health
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Immune Response and Inflammation
- Ideological and Political Education
- Liver physiology and pathology
- Multiple and Secondary Primary Cancers
- COVID-19 and healthcare impacts
- Antioxidants, Aging, Portulaca oleracea
Chongqing Medical University
2012-2025
Dalian Medical University
2012-2025
Second Affiliated Hospital of Chongqing Medical University
2012-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Kaohsiung Medical University
2024
National Sun Yat-sen University
2024
Office of Infectious Diseases
2023
Ministry of Education of the People's Republic of China
2022
Massachusetts General Hospital
2015-2018
Harvard University
2015-2018
Abstract Background and Aims The safety antibody responses of coronavirus disease 2019 (COVID‐19) vaccination in patients with chronic hepatitis B (CHB) virus infection is still unclear, exploration COVID‐19 CHB significant clinical practice. Methods 362 adult 87 healthy controls at an interval least 21 days after a full‐course (21–105 days) were enrolled. Adverse events (AEs) collected by questionnaire. profiles 1, 2 3 months elucidated determination anti‐spike IgG, anti‐receptor‐binding...
It is important to know the safety and efficacy of vaccination in immunocompromised people living with HIV (PLWH), but currently, there limited data on inactivated SARS-CoV-2 vaccines' immune responses PLWH. In this prospective observational study, 139 PLWH 120 healthy controls were enrolled monitored for 21–105 days after a two-dose vaccination. The safety, anti-receptor binding domain IgG (anti-RBD-IgG) anti-spike-IgG responses, RBD-specific memory B cell (MBC) evaluated. overall adverse...
Abstract Motivation The growing number of microbial reference genomes enables the improvement metagenomic profiling accuracy but also imposes greater requirements on indexing efficiency, database size and runtime taxonomic profilers. Additionally, most profilers focus mainly bacterial, archaeal fungal populations, while less attention is paid to viral communities. Results We present KMCP (K-mer-based Metagenomic Classification Profiling), a novel k-mer-based tool that utilizes genome...
Background Among the advantaged population with clinical cure of chronic hepatitis B, inactive B virus carriers (IHCs) and nucleoside analog-experienced patients have similar serological manifestations. This study established non-interferon-treated groups as controls to compare efficacy pegylated interferon α-2b (Peg-IFNα-2b) in achieving between IHCs analog (NA)-experienced patients. Method A total 270 were enrolled this observational study. The IHC cohort comprised 55 who received...
Stem cell senescence is an important and current hypothesis accounting for organismal aging, especially the hematopoietic stem (HSC). Ginsenoside Rg1 main active pharmaceutical ingredient of ginseng, which a traditional Chinese medicine. This study explored protective effect ginsenoside on Sca-1⁺ stem/progenitor cells (HSC/HPCs) in mouse model d-galactose-induced aging. The mimetic aging was induced by continuous injection d-gal 42 days, C57BL/6 mice were respectively treated with Rg1,...
Abstract HCV replication disrupts normal endoplasmic reticulum (ER) function and activates a signaling network called the unfolded protein response (UPR). UPR is directed by three ER transmembrane proteins including ATF6, IRE1 PERK. increases TGF-β1 oxidative stress, which play important roles in liver fibrogenesis. has been shown to induce through generation of reactive oxygen species (ROS) p38 MAPK, JNK, ERK1/2 NFκB-dependent pathways. However, relationship between HCV-induced stress...
Long noncoding RNAs (lncRNAs) play a critical role in the regulation of many important cellular processes. However, mechanisms by which lncRNAs regulate viral infection and host immune responses are not well understood. We sought to explore lncRNA hepatitis C virus (HCV) interferon response. performed RNA sequencing (RNAseq) Huh7.5.1 cells with or without alpha (IFNα) treatment. Clustered regularly interspaced short palindromic repeats/Cas9 guide (gRNA) was used knock out selected genes. The...
ABSTRACT The elongation factor Tu GTP binding domain-containing protein 2 (EFTUD2) was identified as an anti-hepatitis C virus (HCV) host in our recent genome-wide small interfering RNA (siRNA) screen. In this study, we sought to further determine EFTUD2's role HCV infection and investigate the interaction between EFTUD2 other regulators involved innate immune (RIG-I, MDA5, TBK1, IRF3) JAK-STAT1 pathways. We found that decreased expression of viral sensors RIG-I MDA5 HCV-infected Huh7...
Background and aims HCV genotype (GT) 3 is associated with rapid liver disease progression. However, the progression its risk factors in patients GT infection after sustained virological response (SVR) following direct-acting antivirals (DAAs) remain unclear. Therefore, we aimed to investigate of SVR. Methods This was a retrospective cohort study who achieved SVR by DAAs. The clinical outcome overall (OLDP), defined as newly diagnosed compensated cirrhosis, decompensated or hepatocellular...
Polycomb Repressive Complex 2 (PRC2) is a multi‐subunit complex responsible for tri‐methylating histone H3 at lysine 27 (H3K27me3), which marks gene silencing. Dysregulation of PRC2, particularly through the overexpression its component EZH2, linked to cancers and developmental disorders. Inhibiting EZH2 activity can reduce cancer cell proliferation tumorigenesis, making it target drug development. In this study, we screened over two thousand compounds identified pyrroloquinoline quinone...
Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome, and the incidence of invasive fungal infection (IFI) among hospitalized patients with ACLF steadily increasing. The aim this study to develop diagnostic nomogram assist in identification IFI these patients. A retrospective included 705 from January 1, 2019, October 31, 2023, randomly divided into training (n = 493) validation 212) cohorts. diagnosis includes proven probable diagnosis. Kaplan analysis was performed analyze...
ABSTRACT Hepatitis C virus (HCV) infection has been shown to regulate microRNA 130a (miR-130a) in patient biopsy specimens and cultured cells. We sought identify miR-130a target genes explore the mechanisms by which regulates HCV hepatitis B (HBV) replication. used bioinformatics software, including miRanda, TargetScan, PITA, RNAhybrid, predict potential genes. its were overexpressed or knocked down use of small interfering RNA (siRNA) clustered regularly interspaced short palindromic repeat...
Abstract Objective: We conducted this study to compare the efficacy and safety of entecavir tenofovir in treatment treatment-naïve HBV e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB) for 144 weeks. Methods: A total 320 HBeAg-positive CHB who received randomly a single regimen either capsule (ETV) (n = 160) or disoproxil fumarate (TDF) weeks were consecutively enrolled from 14 tertiary hospitals university China between January 2012 December 2014. Results: Two groups showed...
Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese population. However, limited literature exists explore effect of obesity on humoral and cellular immune response these vaccines. In this study, 132 high BMI (Body mass index) (obesity overweight, ≥ 24 kg/m2) 82 normal (BMI < participants were enrolled. Adverse events (AEs), Spike receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibodies (NAbs), specific B-cell T-cell responses evaluated 21-105...
Abstract People living with HIV (PLWH) have poor outcomes from severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2); vaccination reduces the associated mortality. The humoral immune response dynamics after booster inactivated vaccinations in PLWH remain unclear. In this longitudinal observational study, 100 primary SARS‐CoV‐2 were consecutively recruited and followed up. After (BV), neutralizing antibodies (NAbs) detected at 1 month all PLWH, titer increased sixfold compared to that...
Currently, the relationship between nutritional indices and prognosis of hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors (ICIs) tyrosine kinase (TKIs) remains unclear. This study aims to investigate prognostic value psoas muscle index (PMI), (PNI), body mass (BMI), geriatric risk (GNRI) in HCC ICIs combined TKIs. A total 124 male were included this study. PNI, PMI, BMI, GNRI calculated at beginning treatment. The Cox proportional hazards model was used...
The antibody and B cell responses after inactivated SARS-CoV-2 vaccination have not been well documented in patients with autoimmune liver disease (AILD). Therefore, we conducted a prospective observational study that included AILD healthy participants as controls between July 1, 2021, September 30, at the Second Affiliated Hospital of Chongqing Medical University. All adverse events (AEs) COVID-19 were recorded graded. Immunoglobulin (Ig)-G antibodies against receptor-binding domain (RBD)...
Given the pandemic of severe acute respiratory syndrome coronavirus 2 Omicron variants, booster vaccination (BV) using inactivated virus vaccines (the third dose) has been implemented in China. However, immune responses after BV, especially those against Omicron, patients with chronic hepatitis B (HBV) infection (CHB) are unclear. In this prospective longitudinal study, 114 CHB and 68 healthy controls (HCs) were recruited receiving vaccination. The anti-receptor-binding domain (RBD)...
Abstract Patients with anti‐melanoma differentiation‐associated gene 5 (anti‐MDA5) dermatomyositis (DM) have a higher risk of coronavirus disease 2019 (COVID‐19) infection. In this longitudinal observational study, we aimed to investigate the clinical and immunological features these patients after COVID‐19 A total 73 anti‐MDA5 DM were recruited from Second Affiliated Hospital Chongqing Medical University during Omicron wave epidemic. Clinical data collected by questionnaire survey...