A5101858525- Viral Infections and Outbreaks Research
- Monoclonal and Polyclonal Antibodies Research
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Microbial Metabolic Engineering and Bioproduction
- COVID-19 epidemiological studies
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Protein Structure and Dynamics
- Glycosylation and Glycoproteins Research
- Microbial Metabolism and Applications
- Viral gastroenteritis research and epidemiology
- Heat shock proteins research
- MicroRNA in disease regulation
- Legume Nitrogen Fixing Symbiosis
- Oral microbiology and periodontitis research
- Enzyme Production and Characterization
- Plant biochemistry and biosynthesis
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Protein purification and stability
- Viral Infectious Diseases and Gene Expression in Insects
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
Second Military Medical University
2011-2024
Purdue University West Lafayette
1993-2024
Third Hospital of Nanchang
2024
Changhai Hospital
2011-2024
Weldon City Schools
2023
China Agricultural University
2007-2022
Huzhou Central Hospital
2022
Yunnan Agricultural University
2022
We present an "opportunistic" transmission scheduling policy that exploits time-varying channel conditions and maximizes the system performance stochastically under a certain resource allocation constraint. establish optimality of scheme also every user experiences improvement over any nonopportunistic when users have independent values. demonstrate via simulation results is robust to estimation errors works well for nonstationary scenarios, resulting in improvements 20%-150% compared with...
Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role cholesterol in cancer metastasis. By using label-free Raman spectromicroscopy, found an aberrant accumulation cholesteryl ester human pancreatic specimens cell lines, mediated by acyl-CoA acyltransferase-1 (ACAT-1) enzyme. Expression ACAT-1 showed correlation with poor patient survival. Abrogation esterification, either inhibitor or shRNA knockdown, significantly...
Abstract Objective To evaluate the diagnostic accuracy and safety of using magnetically guided capsule endoscopy with a detachable string (ds-MCE) for detecting grading oesophagogastric varices in adults cirrhosis. Design Prospective multicentre study. Setting 14 medical centres China. Participants 607 (>18 years) cirrhosis recruited between 7 January 2021 25 August 2022. underwent ds-MCE (index test), followed by oesophagogastroduodenoscopy (OGD, reference test) within 48 hours. The...
Abstract Biofilms formations of spoilage and pathogenic bacteria on food or contact surfaces have attracted increasing attention. These events may lead to a higher risk foodborne disease transmission. While Pseudomonas lundensis is one the most important that cause in chilled meat, its capability for biofilm formation has been seldom reported. Here, we investigated characteristics P. mainly by using crystal violet staining, confocal laser scanning microscopy (CLSM). The swarming swimming...
ABSTRACT The elongation factor Tu GTP binding domain-containing protein 2 (EFTUD2) was identified as an anti-hepatitis C virus (HCV) host in our recent genome-wide small interfering RNA (siRNA) screen. In this study, we sought to further determine EFTUD2's role HCV infection and investigate the interaction between EFTUD2 other regulators involved innate immune (RIG-I, MDA5, TBK1, IRF3) JAK-STAT1 pathways. We found that decreased expression of viral sensors RIG-I MDA5 HCV-infected Huh7...
Brassica napus is an important oilseed crop in the world, and mechanism of seed oil biosynthesis B. remains unclear. In order to study generate germplasms for breeding, ethyl methanesulfonate (EMS) mutant population with ~100 000 M2 lines was generated using Zhongshuang 11 as parent line. The EMS-induced genome-wide mutations M2-M4 plants were assessed. average number including single nucleotide polymorphisms insertion/deletion 21 177, 28 675 17 915, respectively. effects on gene function...
Hydrogels of the synthetic clay Laponite® and Laponite®‐poly (ethylene oxide) (PEO) have long been studied as model systems to understand fundamental aspects colloidal disks colloid‐polymer systems. More recently, these explored for a variety biomedical applications. However, there is limited information in literature on properties Laponite Laponite‐polymer gels at pH < 9. Here, we report rheological behavior Laponite‐PEO biologically relevant conditions (e.g. physiological ionic...
Abstract Background Pseudomonas fluorescens ( P. ) has been detected in respiratory samples from patients. However, no previous reports have published about these cultures lung tissues. Case presentation Here, we report a case of pneumonia caused by . was identified biopsy specimens for the first time this case. According to antibiotic susceptibility testing (AST) , patient given ciprofloxacin treatment. The temperature then returned normal. Chest CT examination revealed improvements...
Japanese encephalitis virus (JEV), a mosquito-borne Flavivirus, causes acute viral with high morbidity and mortality in humans animals. MicroRNAs (miRNAs) are small noncoding RNAs that important modulators of the intricate host-pathogen interaction networks. However, our knowledge changes occur miRNAs host cells after JEV infection is still limited. To understand molecular pathogenesis at level posttranscriptional regulation, we used Illumina deep sequencing to sequence two RNA libraries...
Autoinducer-2 (AI-2) is a universal signal molecule and enables an individual bacteria to communicate with each other ultimately control behaviors of the population. Harnessing character AI-2, two kinds AI-2 "controller cells" ("consumer "supplier cells") were designed "reprogram" entire population.For consumer cells, genes associated uptake processing which includes LsrACDB, LsrFG, LsrK, overexpressed in varying combinations. Four cell strains constructed: Escherichia coli MG1655 pLsrACDB...
Transmissible gastroenteritis virus (TGEV; Coronaviridae family) causes huge economic losses to the swine industry. MicroRNAs (miRNAs) play a regulatory role in viral infection and may be involved mammalian immune response. Here, we report comprehensive analysis of host miRNA expression TGEV-infected testis (ST) cells. Deep sequencing generated 3,704,353 2,763,665 reads from uninfected ST cells infected cells, respectively. The were aligned known Sus scrofa pre-miRNAs miRBase 19, identifying...
As one of the most important enteric viruses, sapovirus (SaV) can infect humans and a variety animals. Until now, 19 SaV genogroups have been identified, among which 4 from human (GI, GII, GIV, GV) 8 swine (GIII, GV-GXI). Porcine (PoSaV) GIII has prevalent in China; however, status PoSaV infection Yunnan province remains unknown. In this study, 202 fecal samples were collected piglets associated with outbreaks acute diarrhea between January May 2020. detection revealed that total rate was...
Ebola virus (EBOV) infections continue to pose a global public health threat, with high mortality rates and sporadic outbreaks in Central Western Africa. A quantitative understanding of the key processes driving EBOV assembly budding could provide valuable insights inform drug development. Here, we use computational model evaluate matrix assembly. Our focuses on kinetics VP40, protein EBOV, its interaction phosphatidylserine (PS) host cell membrane. It has been shown that mammalian cells...
Background The benefit of first-line use sodium-dependent glucose transport 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in type diabetes mellitus (T2DM) with low risk cardiovascular diseases are not clear. Methods PubMed, EMBASE Cochrane Library databases were searched to identify eligible randomized controlled trials. We used the odds ratio (OR) mean difference (MD) corresponding 95% confidence interval (CI) assess dichotomous continuous variable,...
Ebola virus (EBOV) infection is threatening human health, especially in Central and West Africa. Limited clinical trials the requirement of biosafety level-4 laboratories hinder experimental work to advance our understanding EBOV evaluation treatment. In this work, we use a computational model study assembly budding process evaluate effect fendiline on these processes context fluctuating host membrane lipid levels. Our results demonstrate for first time that VP40 filaments may follow...
Structure characterization of intrinsically disordered proteins (IDPs) remains a key obstacle in understanding their functional mechanisms. Due to the highly dynamic feature IDPs, structure ensembles instead static unique structures are often derived from experimental data. Several state-of-the-art computational methods have been developed select an optimal ensemble pregenerated pool, but they suffer low efficiency for large IDPs. Here we present matching pursuit genetic algorithm (MPGA)...
A biosensor screening assay based on the synthesis of betaxanthin was applied to relatively high throughput L-tyrosine mutant library. In assays, fluorescence output showed a linear relationship between extracellular content and yellow pigment formation. addition, accumulation high-yield strain can be easily distinguished with naked eye compared wild-type strain. As result, numerous mutants that exhibited significantly increased coloration, were screened out after random mutagenesis,...