A5049255954- Nanoplatforms for cancer theranostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Evolution and Genetic Dynamics
- Nanoparticle-Based Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Coccidia and coccidiosis research
- Autophagy in Disease and Therapy
- Pharmaceutical and Antibiotic Environmental Impacts
- Quinazolinone synthesis and applications
- Additive Manufacturing and 3D Printing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Bacterial Genetics and Biotechnology
- Synthesis and Biological Evaluation
- Antibiotic Resistance in Bacteria
- Industrial Vision Systems and Defect Detection
- Advancements in Transdermal Drug Delivery
- Animal Virus Infections Studies
- Erythrocyte Function and Pathophysiology
- Parasitic Diseases Research and Treatment
- Ferroptosis and cancer prognosis
- Bacteriophages and microbial interactions
- Veterinary Pharmacology and Anesthesia
- Marine Toxins and Detection Methods
- MicroRNA in disease regulation
Nanjing Agricultural University
2020-2025
China Pharmaceutical University
2025
Rice University
2021-2024
Xijing University
2022-2023
China University of Geosciences
2023
Nankai University
2017-2018
State Key Laboratory of Medicinal Chemical Biology
2018
University of Electronic Science and Technology of China
2018
There is no effective treatment for patients with poorly differentiated papillary thyroid cancer or anaplastic (ATC). Anlotinib, a multi-kinase inhibitor, has already shown antitumor effects in various types of carcinoma phase I clinical trial. In this study, we aimed to better understand the effect and efficacy anlotinib against cells vitro vivo. We found that inhibits cell viability ATC lines, likely due abnormal spindle assembly, G2/M arrest, activation TP53 upon treatment. Moreover,...
Maduramicin, an extensively used anticoccidial drug, has been introduced into environment due to poorly absorbed in the intestine of broiler chicken. To understand potential ecological toxicity maduramicin on aquatic organisms, acute and subacute toxicity, hemolymph biochemistry, histopathology expressions drug metabolism stress response genes crayfish (Procambius clarkii) were investigated this study. For first time, 96 h median lethal concentration (LC50) was 67.03 mg L−1 with a 95%...
Maduramicin ammonium (MAD) is one of the most frequently used anticoccidial agents in broiler chickens. However, high toxicity and low solubility MAD limit its clinical application. In this study, MAD-loaded nanostructured lipid carriers (MAD-NLCs) were prepared to overcome defects by using highly soluble (NLCs). The formulation was optimized via a three-level, three-factor Box-Behnken response surface method. Then, optimal MAD-NLCs evaluated according their hydrodynamic diameter (HD), zeta...
Halofuginone (HF)-loaded TPGS polymeric micelles (HTPM) were successfully fabricated using the thin-film hydration technique. HTPM via intravenous injection have been demonstrated to exert an excellent anticancer effect against triple-negative breast cancer (TNBC) cells and subcutaneous xenografts. In present study, we further explored potential treatment mechanism of orally administered alone in combination with surgical therapy on TNBC orthotopic mouse models.
Background: Halofuginone hydrobromide (HF) is a synthetic analogue of the naturally occurring quinazolinone alkaloid febrifugine, which has potential therapeutic effects against breast cancer, however, its poor water solubility greatly limits pharmaceutical application. D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) water-soluble derivative vitamin E, can self-assemble to form polymeric micelles (PMs) for encapsulating insoluble anti-tumor drugs, thereby effectively enhancing their...
Autoinducer-2 (AI-2) is a universal signal molecule and enables an individual bacteria to communicate with each other ultimately control behaviors of the population. Harnessing character AI-2, two kinds AI-2 "controller cells" ("consumer "supplier cells") were designed "reprogram" entire population.For consumer cells, genes associated uptake processing which includes LsrACDB, LsrFG, LsrK, overexpressed in varying combinations. Four cell strains constructed: Escherichia coli MG1655 pLsrACDB...
Porcine epidemic diarrhea virus (PEDV) is an acute enteric coronavirus, inducing watery and high mortality in piglets, leading to huge economic losses global pig industry. Ivermectin (IVM), FDA-approved antiparasitic agent, characterized by efficacy wide applicability. However, the poor bioavailability limits its application. Since parasitized inside host cells, increasing intracellular drug uptake can improve antiviral efficacy. Hence, we aimed develop nanostructured lipid carriers (NLCs)...
In vitro experimental evolution of pathogens to antibiotics is commonly used for the identification clinical biomarkers associated with antibiotic resistance. Microdroplet emulsions allow exquisite control spatial structure, species complexity, and selection microenvironments such studies. We investigated use monodisperse microdroplets in evolution. Using Escherichia coli adaptation doxycycline, we examined how changes environmental conditions as droplet size, starting lambda value,...
Coccidiosis is a worldwide epidemic intestinal disease with high incidence, which causes huge economic losses. Halofuginone hydrobromide (HF) widely applied as an effective anticoccidial drug in the poultry industry. However, its therapeutic efficacy severely restrained due to toxic effects, poor aqueous solubility and low permeability. Nanotechnology can improve biological effect of drugs, thus, reduce administered doses effects. The objective this study was investigate preventive potential...
Abstract Maduramicin frequently induces severe cardiotoxicity in target and nontarget animals clinic. Apoptotic non‐apoptotic cell death mediate its cardiotoxicity; however, the underlying induced by maduramicin remains unclear. In current study, a recently described “methuosis” caused was defined mammalian cells. Rat myocardial H9c2 used as an vitro model, showing excessively cytoplasmic vacuolization upon (0.0625–5 μg/mL) exposure for 24 h. Maduramicin‐induced reversible of cells time‐...
Microdroplet emulsions allow investigators to build controllable microenvironments for applications in experimental evolution and synthetic ecology. We designed a microfluidic platform that uses highly homogenous microdroplets enable these experiments. also present step-by-step protocol the rapid production of homogeneous suitable evolution. describe protocols propagation serial passage microbial populations across range selection schemes potential spatial structures. For complete details on...
Maduramicin is a toxic ionophore antibiotic that isolated from Streptomyces, frequently occurring in an aquatic environment. To understand the potential role of maduramicin crayfish consumption related Haff disease, mouse model was established this study. Two exposure routes abdominal muscle and hepatopancreas tissue homogenates were given intragastrically to mice different doses for seven days. Action changes, clinical symptoms, feed consumption, body weight, blood biochemistry,...
While electroencephalogram (EEG) based brain-computer interface (BCI) has been widely used for medical diagnosis, health care, and device control, the safety of EEG BCI long neglected. In this paper, we propose Professor X, an invisible robust "mind-controller" that can arbitrarily manipulate outputs through backdoor attack, to alert community potential hazard. However, existing attacks mainly focus on single-target class attacks, they either require engaging training stage target BCI, or...
Daptomycin (DAP) is an antibiotic frequently used as a drug of last resort against vancomycin-resistant enterococci. One the major challenges when using DAP enterococci emergence resistance, which mediated by cell-envelope stress system LiaFSR. Indeed, inhibition LiaFSR signaling has been suggested strategy to "resensitize" DAP. In absence LiaFSR, alternative pathways mediating resistance have identified, including adaptive mutations in enolpyruvate transferase MurAA (MurAAA149E), catalyzes...
Since China has put forward the Belt and Road Initiative in 2013, research on BRI-related countries along sprung up. With advent of era carbon peak neutralization, environmental regulation, as one important methods to control emissions, is becoming increasingly prominent. Research impact pathway regulation emissions implications for protection emission reduction. Based panel data 38 from 2005 2018, this applied linear Tobit model nonlinear dynamic regression (PSTR) evaluate direct impacts...
Canine mammary tumors (CMT) can severely compromise the life quality of affected dogs through local recurrence, distant metastases and ultimately succumb to death. Recently, more attention has been given potential antimetastatic effect maduramicin (MAD) on breast cancer. However, its poor aqueous solubility toxicity normal tissues limit clinical application. Therefore, address drawbacks MAD enhance anticancer effects, MAD-loaded TPGS polymeric micelles (MAD-TPGS) were prepared by a thin-film...
A biosensor screening assay based on the synthesis of betaxanthin was applied to relatively high throughput L-tyrosine mutant library. In assays, fluorescence output showed a linear relationship between extracellular content and yellow pigment formation. addition, accumulation high-yield strain can be easily distinguished with naked eye compared wild-type strain. As result, numerous mutants that exhibited significantly increased coloration, were screened out after random mutagenesis,...