A5076510487- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Pharmaceutical and Antibiotic Environmental Impacts
- Virology and Viral Diseases
- Identification and Quantification in Food
- Clostridium difficile and Clostridium perfringens research
- Veterinary medicine and infectious diseases
- Virus-based gene therapy research
- Animal Nutrition and Physiology
- Toxin Mechanisms and Immunotoxins
- Plant Virus Research Studies
- Antibiotic Resistance in Bacteria
- Animal Disease Management and Epidemiology
- Vector-borne infectious diseases
- Genital Health and Disease
- Parasitic Diseases Research and Treatment
- Engineering Structural Analysis Methods
- Tuberculosis Research and Epidemiology
- Mechanical Failure Analysis and Simulation
- Neonatal and fetal brain pathology
Yunnan Agricultural University
2016-2025
Nanjing Agricultural University
2008
Abstract Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of treatment multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes ( mcr-1 , mcr-2 mcr-3 ) in 213 anal 1,339 nasal swabs from pigs (n = 1,454) nine provinces China, 1,696 cloacal 1,647 oropharyngeal samples poultry 1,836) at live-bird markets 24 provinces. The prevalences (79.2%) geese (71.7%) significantly higher than chickens (31.8%), ducks (34.6%)...
The objective of this study was to investigate the protective effect Crataegus pinnatifida polysaccharide (CPP) on non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in mice. findings demonstrated that CPP improved free acid (FFA)-induced lipid accumulation HepG2 cells and effectively reduced steatosis epididymal fat weight NAFLD mice, as well decreased serum levels TG, TC, AST, ALT, LDL-C. Furthermore, exhibited inhibitory effects expression synthesis genes FASN ACC...
Although many vector-borne agents are potential zoonoses and cause substantial morbidity mortality in dogs worldwide, there limited data on these organisms of China.Quantitative PCRs for were performed to investigate their prevalences convenience whole blood samples obtained from 1114 21 veterinary clinics a commercial dog breeding facility ten provinces China. In addition, the 146 Rhipicephalus sanguineus senso lato 37 Linognathus setosus collected facility.DNAs Babesia gibsoni B. vogeli...
Antimicrobial resistance against colistin has emerged worldwide threatening the efficacy of one last-resort antimicrobials used for treatment Enterobacteriaceae. To investigate presence recently identified genes (mcr-4, mcr-5) in China, we established PCRs to detect mcr-4 and mcr-5 on 213 anal 1,339 nasal swabs from apparently healthy pigs (n = 1,454) nine provinces, 1,696 cloacal 1,647 oropharyngeal samples poultry 1,836) at live-bird markets 24 provinces China. The prevalence swine (41.4%;...
Porcine pseudorabies has long existed in China and is a serious threat to the Chinese farming industry. To understand prevalence genetic variation of porcine virus (PRV) its pathogenicity Yunnan Province, China, we collected 560 serum samples across seven Province regions from 2020 2021 detected anti-gE antibodies these samples. Sixty-one clinical tissue were also pigs with suspected PRV that vaccinated Bartha-K61. PRV-gE found 29.6% (166/560) The positivity rate was 13.1% (8/61). Two...
Endometritis is a reproductive disorder characterized by an inflammatory response in the endometrium, which causes significant economic losses to dairy farming industry.MicroRNAs (miRNAs) are implicated and immune regulation following infection pathogenic bacteria.Recent miRNA microarray analysis showed altered expression of miR-92b cows with endometritis.In present study, we set out investigate regulatory mechanism endometritis.Here, qPCR results first validated that was down-regulated...
In recent years, the prevalence of pseudorabies virus (PRV) has caused huge economic losses to Chinese pig industry. Meanwhile, PRV infection in humans also sounded alarm about its cross-species transmission from pigs humans. To study regional epidemic, serological and epidemiological investigations populations Yunnan Province during 2017-2021 were performed. The results showed that 31.37% (6324/20,158, 95% CI 30.73-32.01) serum samples positive for glycoprotein E (gE)-specific antibodies...
Pseudorabies virus (PRV) can cause fatal encephalitis in newborn pigs and escape the immune system. While there is currently no effective treatment for PRV, Scutellaria baicalensis Georgi polysaccharides (SGP) Rodgersia sambucifolia Hemsl flavonoids (RHF) are traditional Chinese herbal medicines with potential preventive therapeutic effects against PRV infection. In order to explore which one more prevention of infection piglets. We investigate RHF SGP PRV-infected piglets using clinical...
Porcine epidemic diarrhea virus (PEDV) is a highly contagious pathogen responsible for devastating enteric disease and lethal watery diarrhea, leading to significant economic losses in the global swine industry. Understanding epidemiology genetic diversity of PEDV over past decade crucial effective prevention treatment porcine diarrhea. In this study, 1851 fecal samples were collected from pigs exhibiting symptoms across 11 cities Yunnan Province between 2013 2022. The prevalence PEDV, along...
Abstract Pseudorabies virus (PRV) infection leads to viral encephalitis and neurological damage in mice, causing significant symptoms brain damage. This study aimed investigate the cellular mechanisms of PRV-induced encephalopathy role matrix metalloproteinase-9 (MMP-9) blood–brain barrier (BBB) disruption. We found that PRV increased number astrocytes induced a phenotypic shift from A2 A1 subtype, which was associated with secretion MMP-9. MMP-9 identified as critical mediator BBB...
Erigeron breviscapus exhibits anti-inflammatory properties, protects neuronal cells and enhances immune function. Modern traditional Chinese medicine fermentation techniques can increase the bioactive compound content in breviscapus. However, its potential therapeutic effects against porcine pseudorabies virus (PRV) remain unclear. A PRV infection model was established mouse trigeminal ganglion (TG) to determine optimal antiviral mode of action flavonoids from fermented (FEBF). Additionally,...
Chlamydia suis is an important, globally distributed, highly prevalent and diverse obligate intracellular pathogen infecting pigs. To investigate the prevalence genetic diversity of C. in China, 2,137 nasal, conjunctival, rectal swabs as well whole blood lung samples pigs were collected 19 regions from ten provinces China this study.We report overall positivity 62.4% (1,334/2,137) following screening by spp. 23S rRNA-based FRET-PCR high-resolution melting curve analysis confirmatory...
As one of the most important enteric viruses, sapovirus (SaV) can infect humans and a variety animals. Until now, 19 SaV genogroups have been identified, among which 4 from human (GI, GII, GIV, GV) 8 swine (GIII, GV-GXI). Porcine (PoSaV) GIII has prevalent in China; however, status PoSaV infection Yunnan province remains unknown. In this study, 202 fecal samples were collected piglets associated with outbreaks acute diarrhea between January May 2020. detection revealed that total rate was...
With the improvement of consumers' requirements for pork quality, method crossbreeding with excellent local pig breeds to improve meat quality is popular. Saba has high reproduction rate, good and utilization rate roughage, but its characteristics have not been fully developed utilized. To promote development pigs production high-quality pork, traits glycolysis potential Duroc × (Landrace Yorkshire) (DLY), Berkshire (Duroc Saba) (BDS), (Berkshire (DBS) three-way crossbred were compared. The...
Hepatitis E is a disease of major public-health concern mainly in developing countries. Although molecular and sero-epidemiological investigations HEV have been performed many provinces China, the epidemiological data from Yunnan Province are limited genotypes not be fully characterized. In this study prevalence characteristics hepatitis virus (HEV) detected pigs province, China was evaluated.A total 13 out 187 pig fecal samples collected 2011 revealed positive results; likewise, 7 69 2012...
Classical swine fever virus (CSFV), the causative agent of classical (CFS), is a highly contagious disease that poses serious threat to Chinese pig populations.Many provinces China, such as Shandong, Henan, Hebei, Heilongjiang, and Liaoning provinces, have reported epidemics CSFV, while references epidemic CSFV in Yunnan province are rare. This study examined characteristics province.In this study, 326 tissue samples were collected from different regions 2015 2021. A reverse...
Objective: The intestinal microbiota plays an important role in host physiology, metabolism, immunity, and behavior. And genetics could influence the gut of hybrid animals. three-way cross model is commonly utilized commercial pig production; however, use this to analyse microbial composition rarely reported. Methods: Two pigs were selected, with Saba as starting maternal pig: Duroc× (Berkshire×Saba) (DBS) pig, Berkshire×(Duroc×Saba) (BDS) pig. One hundred each reared from 35 days (d) 210 d....
In order to explore the relationship between lung and intestinal injury microorganisms in piglets caused by PRV infection.36 were randomly divided into blank group exposed (or group). PBS 1mL/Piggy given nasal drip at 0d, clinical symptoms recorded every day. Three each sacrificed 12h, 24h, 3d, 10d 14d, respectively. The lungs, colon contents collected observe pathological sections assess damage. antigenic localization expression of PRV, TLR4, NF-κB MYD88 detected immunohistochemistry, sIgA,...
<title>Abstract</title> The pseudorabies virus (PRV) is a highly neurotropic zoonotic pathogen. PRV infection can lead to neuroinflammation and damage the blood-brain barrier (BBB). Elevated matrix metalloproteinase-9 (MMP-9) expression has detrimental impairs BBB function. However, source of elevated MMP-9 function in invasion central nervous system (CNS), mechanism by which breaches BBB, remain poorly understood. This study explored role permeation clarified molecular pathways involved...