A5042888611- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Complement system in diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Speech and dialogue systems
- Influenza Virus Research Studies
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Erythrocyte Function and Pathophysiology
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Clinical Nutrition and Gastroenterology
- Nicotinic Acetylcholine Receptors Study
- Liver Diseases and Immunity
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Southwest Hospital
2018-2022
Army Medical University
2018-2022
Southwest General Health Center
2022
Dascena (United States)
2021
Wuhan University
2020
Hubei Zhongshan Hospital
2020
Johns Hopkins University
2013
National Institutes for Food and Drug Control
2010
Abstract An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2 pathogenesis lethality, but the mechanism remains unclear. In this study, N proteins of were found bind MASP-2, key serine protease in lectin pathway complement activation, resulting aberrant activation aggravated inflammatory lung injury. Either blocking protein:MASP-2 interaction or suppressing can significantly alleviate protein-induced hyper-activation injury vitro vivo . Complement was also observed...
Abstract Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses, but underlying mechanism remains unclear. In this study, N proteins including severe acute respiratory syndrome coronavirus (SARS-CoV), middle east (MERS-CoV) 2 (SARS-CoV-2), were found bind MASP-2, a key serine protease in lectin pathway complement activation, resulting excessive activation by potentiating MBL-dependent MASP-2 deposition C4b, activated C3 C5b-9....
The purpose of this study was to compare the efficacy and safety utidelone plus capecitabine for advanced first-line versus second-line or above therapy in metastatic breast cancer patients who had previously received anthracycline taxane. At same time, we compared vinorelbine cisplatin treatment cancer.A retrospective cohort 11 with treated taxane (including neoadjuvant adjuvant therapies) capecitabine, 32 above, 60 between October 2011 August 2022 collected. first second groups were third...
Butyrylcholinesterase (BChE), an ester hydrolase produced mainly by the liver, hydrolyzes certain short-acting neuromuscular blocking agents, like succinylcholine and mivacurium that are widely used during anesthesia. Patients with BChE deficiency possibly in danger of postanesthetic apnea. Hereditary results from mutations BCHE gene located on chromosome 3, 3q26.1-q26.2, between nucleotides 165,490,692–165,555,260. This study describes a novel mutation child deficiency. In general, this...
GB Virus Type C (GBV-C), a blood-borne flavivirus currently infects about one sixth of the world’s population. Its transmission has been reported through parenteral, sexual and vertical routes. Unusually for RNA viruses, it exhibits high degree conservation polyprotein sequence. The geographical distribution GBV-C suggests an African origin long-term co-evolution in human population but without any known pathogenicity. aim this study was to describe different sub-types virus Southern...
Abstract Corona virus disease 2019 (COVID-19) is currently a global pandemic It presents as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to COVID-19 infection. Despite the widespread use of symptomatic, antiviral, , and supportive treatment, daily death toll from still rising. The most common lethal complication distress (ARDS). Mechanical ventilation one necessary support methods treating ARDS. Heliox (Helium-oxygen mixture) inhalation can reduce work breathing, improve...
Objective: To evaluate the outcomes of splenectomy in treatment relapsed/refractory autoimmune hemolytic anemia (AIHA). Methods: Retrospective analysis was performed 30 cases with AIHA who were treated our hospital. The pre- and post-operative blood routine indexes responses followed up. Results: Among patients, 20 pure (including 13 patients warm antibody AIHA, 2 warm-cold double 5 Coombs negative AIHA) 10 Evans syndrome. short-term response evaluated 10-14 days after operation, overall...
Presentations S81was found among 20% children.Complications were seen in 24 children, hemiparesis 11 and seizure disorder 5. Conclusion: Brain abscess conjunction with congenital cardiac malformations have a different sequel attention should be given towards correct timely diagnosis as delayed surgical drainage has high morbidity mortality.
Objectives: Shigella species are the cause of acute infectious diarrhea.Approximately 40 million cases shigellosis with 600,000 deaths reported annually throughout world.The highest incidence disease occurs among young children from 1 to 5 years age.There four Shigella: S. dysenteriae, flexneri, boydii and sonnei few exceptions shigellae harbored by humans transferred fecal oral rout.As many show multiple antibiotic resistance markers on plasmid, if therapy is undertaken, it advised that...
Abstract Objective: To compare the epidemiological and clinical characteristics of confirmed suspected corona virus disease 2019 (COVID-19) cases via process “triage-screening-isolation-transfer” in hospitals non-epidemic areas. Methods: The general data, history, symptoms, laboratory examination, chest computed tomography (CT) imaging 38 patients with COVID-19, admitted between January 21 March 5, 2020, were analyzed. Results: According to results novel severe acute respiratory syndrome...
Abstract Background: The aim of this study was to investigate the clinicopathological significance SIX1/ EYA1 in chronic hepatitis B (CHB) and other liver diseases. Materials methods: Both SIX1 levels were detected human serum tissues by enzyme linked immunosorbent assay (ELISA) immunofluorescent staining, respectively. Results: Serum 7.24±0.11 ng/ml 25.21±0.51 ng/ml, respectively, 313 CHB patients, these values significantly higher than those 33 healthy controls (2.84±0.15ng/ml...
Corona virus disease 2019 (COVID-19) is currently a global pandemic It presents as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to COVID-19 infection. Despite the widespread use of symptomatic, antiviral, and supportive treatment, daily death toll from still rising. The most common lethal complication distress (ARDS). Mechanical ventilation one necessary support methods treating ARDS. Heliox (Heliumoxygen mixture) inhalation can reduce work breathing, improve oxygenation,...
Introduction: COVID-19 continues to spread across the globe, and effective treatment of remains a crucial area research. While corticosteroids remdesivir are currently recommended for in United States, particularly patients receiving supplemental oxygen, identifying likely respond positively these treatments is necessary effectively allocate limited resources decrease risk adverse events. This study evaluates potential machine learning algorithms identify hospitalized most experience...