A5082815416- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- CAR-T cell therapy research
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Biosimilars and Bioanalytical Methods
- Natural product bioactivities and synthesis
- Pneumonia and Respiratory Infections
- Protein purification and stability
- Bacterial Infections and Vaccines
- Traditional Chinese Medicine Analysis
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Weed Control and Herbicide Applications
National Institutes for Food and Drug Control
2016-2025
Hunan Academy of Agricultural Sciences
2021-2025
Institute of Plant Protection
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Hunan Agricultural University
2021-2024
Biotechnology Research Institute
2024
Woosong University
2024
Shenyang Pharmaceutical University
2019-2024
China Electronics Standardization Institute
2015-2024
Inner Mongolia Electric Power Survey & Design Institute (China)
2024
Enterovirus 71 (EV71) is one of the major causative agents outbreaks hand, foot, and mouth disease or herpangina worldwide. This phase 3 trial was designed to evaluate efficacy, safety, immunogenicity an EV71 vaccine.We conducted a randomized, double-blind, placebo-controlled, multicenter in which 10,007 healthy infants young children (6 35 months age) were randomly assigned 1:1 ratio receive two intramuscular doses either vaccine placebo, 28 days apart. The surveillance period 12 months....
Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease in children may be fatal. A vaccine against EV71 needed.We conducted randomized, double-blind, placebo-controlled phase 3 trial involving healthy 6 to months age Guangxi Zhuang Autonomous Region, China. Two doses an inactivated or placebo were administered intramuscularly, with 4-week interval between doses, monitored for up 11 months. The primary end point was protection caused by EV71.A total 12,000 randomly assigned...
COVID-19 vaccines emerging from different platforms differ in efficacy, duration of protection, and side effects. To maximize the benefits vaccination, we explored utility employing a heterologous prime-boost strategy which combinations four types leading vaccine candidates that are undergoing clinical trials China were tested mouse model. Our results showed sequential immunization with adenovirus vectored followed by inactivated/recombinant subunit/mRNA administration specifically increased...
It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into host cell. Picornaviruses simple models for such viruses, and initiate this uncoating process through particle expansion, which reveals channels internal capsid proteins viral genome presumably exit particle, although has not been clearly seen until now. Here we present atomic structure an intermediate major human picornavirus pathogen CAV16, VP1 partly extruded from...
Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus is the most significant, being responsible for thousands of deaths each year in Asia. The structural and molecular basis this not fully understood. Here, we report cryo-electron microscopy structure mature at near-atomic resolution, which reveals an unusual "hole" on surface, surrounded by five encephalitic-specific motifs implicated receptor binding. Glu138 E, highly conserved encephalitic...
Abstract Background The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace controlling cervical cancer. A phase III clinical trial was conducted to evaluate efficacy, safety, immunogenicity a novel Escherichia coli-produced bivalent HPV-16/18 vaccine. Methods multicenter, randomized, double-blind started on November 22, 2012 in China. In total, 7372 eligible women aged 18–45 years were age-stratified randomly assigned receive three doses test or...
Empty virions are inadvertent by-products of recombinant adeno-associated virus (rAAV) packaging process, resulting in vector lots with mixtures full and empty at variable ratios. Impact on the efficiency side-effects rAAV transduction has not been well characterized. Here, we generated partially completely AAV8 virions, fully packaged rAAV8 as ratios (REVs). The aforementioned dosing formulations expressing either cellular (
The influenza virus (IV) triggers a series of signalling events inside host cells and induces complex cellular responses. Studies have suggested that factors play an essential role in IV replication. MicroRNAs (miRNAs) represent class small non-coding RNAs target mRNAs, triggering either translation repression or RNA degradation. Emerging research suggests host-derived miRNAs are involved mediating the host-IV interaction. Using miRNA microarrays, we identified several aberrantly expressed...
Unlike the well-established picture for entry of enveloped viruses, mechanism cellular non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models such and initiate this process by their functional receptors. Here we present structural studies SCARB2, a receptor important human enterovirus 71 (EV71). SCARB2 is responsible attachment as well uncoating EV71. Differences in structures under neutral acidic conditions reveal that undergoes pivotal...
Abstract Leptospirosis, caused by pathogenic Leptospira spp., has recently been recognized as an emerging infectious disease worldwide. Despite its severity and global importance, knowledge about the molecular pathogenesis virulence evolution of spp. remains limited. Here we sequenced analyzed 102 isolates representing sources. A high genomic variability were observed among different species, which was attributed to massive gene gain loss events allowing for adaptation specific niche...
Structurally and genetically, human herpesviruses are among the largest most complex of viruses. Using cryo-electron microscopy (cryo-EM) with an optimized image reconstruction strategy, we report herpes simplex virus type 2 (HSV-2) capsid structure at 3.1 angstroms, which is built up about 3000 proteins organized into three types hexons (central, peripentonal, edge), pentons, triplexes. Both pentons contain major protein, VP5; also a small VP26; triplexes comprise VP23 VP19C. Acting as core...
Since the outbreak of COVID-19, a variety vaccine platforms have been developed. Amongst these, inactivated vaccines authorized for emergency use or conditional marketing in many countries. To further enhance protective immune responses populations that completed vaccination regimen, we investigated immunogenic characteristics different and tried homologous heterologous boost strategy post two doses mouse model. Our results showed humoral cellular induced by when administered individually...
Frequent herbicide use selects for resistance in weeds. Cytochrome P450s are important detoxification enzymes responsible plants. We identified and characterized a candidate P450 gene (BsCYP81Q32) from the problematic weed Beckmannia syzigachne to test whether it conferred metabolic acetolactate synthase-inhibiting herbicides mesosulfuron-methyl, bispyribac-sodium, pyriminobac-methyl. Transgenic rice overexpressing BsCYP81Q32 was resistant three herbicides. Equally, ortholog OsCYP81Q32 more...