A5103176325- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Child Nutrition and Water Access
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- Physiological and biochemical adaptations
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Animal Behavior and Reproduction
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Immune responses and vaccinations
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Advancements in Transdermal Drug Delivery
- Planarian Biology and Electrostimulation
- Bird parasitology and diseases
Hebei Provincial Center for Disease Control and Prevention
2015-2025
National Center for Nanoscience and Technology
2022
Guangxi Center for Disease Prevention and Control
2022
Hebei Normal University
2013-2021
Institute of Zoology
2015
Chinese Academy of Sciences
2008-2015
Centers for Disease Control and Prevention
2014
Institute of High Energy Physics
2008-2010
Peking University Cancer Hospital
1989
Peking University
1989
A vaccine against COVID-19 is urgently needed for older adults, in whom morbidity and mortality due to the disease are increased. We aimed assess safety, tolerability, immunogenicity of a candidate vaccine, CoronaVac, containing inactivated SARS-CoV-2, adults aged 60 years older.We did randomised, double-blind, placebo-controlled, phase 1/2 clinical trial CoronaVac healthy Renqiu (Hebei, China). Vaccine or placebo was given by intramuscular injection two doses (days 0 28). Phase 1 comprised...
A universal rotavirus (RV) immunization program is a potentially cost-effective measure for preventing RV infection in China. However, the efficacy of only licensed vaccine (Lanzhou lamb vaccine, LLR), which made by domestic manufacturer, has not been proven properly designed clinical trial. In October 2011 to March 2012, potential protection provided LLR, case-control study nested population-based active diarrhea surveillance children <5 years age was conducted rural Zhengding county....
Abstract Importance Whether herd immunity through mass vaccination is sufficient to curb SARS-CoV-2 transmission requires an understanding of the duration vaccine-induced immunity, and necessity timing booster doses. Objective: To evaluate immune persistence two priming doses CoronaVac, immunogenicity safety a third dose in healthy adults ≥60 years. Design, setting, participants: We conducted vaccine study built on single-center, randomized, double-blind phase 1/2 trial two-dose schedule...
Abstract Determining the duration of immunity induced by booster doses CoronaVac is crucial for informing recommendations regimens and adjusting immunization strategies. In two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials, immunogenicity safety four are assessed in adults aged 18 to 59 years one regimen 60 older, respectively. Serious adverse events occurring within 6 months after recorded as pre-specified secondary endpoints, geometric mean titres...
Objective: To explore the association between different feeding methods during first six months after birth and physical growth of children aged 3 to 5 years. Methods: Data were from "Taicang Wuqiang mother-child cohort study"(TAWS) in China. Children enrolled at November 2016 September 2020 followed up 1, 2, 3, 6, 8, 12, 18, 24 months, as well ages Based on within age, categorized into an "exclusive breastfeeding group" a "formula-feeding group". Birth-related information practices 8...
To assess the immune persistence conferred by a Chinese hamster ovary (CHO)-derived hepatitis B vaccine (HepB) 17 to 20 years after primary immunization during early life.Participants born between 1997 and 1999 who received full course of vaccination with HepB (CHO) had no experience booster were enrolled. Blood samples required from each participant for measurement surface antibody (anti-HBs), antigen core levels. For those possessed an anti-HBs < 10 mIU/mL, single dose was administered, 30...
Despite the considerable disease burden caused by disease, rotavirus vaccine has not been introduced into routine national immunization schedule, and norovirus vaccines are being developed without a comprehensive understanding of gastroenteritis epidemiology. To bridge this knowledge gap, we investigated viral in rural China.Between October 2011 December 2013, population-based surveillance was conducted Zhengding Sanjiang counties China. Stool samples were collected from children <5 years...
A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine (HRV) against gastroenteritis (RVGE). total 6400 participants aged 6-12 weeks were enrolled randomly assigned either HRV (n = 3200) or placebo group. All subjects received three oral doses four apart. The (VE) RVGE caused by serotypes contained evaluated from 14 days after administration...
The Zagreb regimen has been used for 20 years in various countries. In China, until 2010, the schedule was only approved purified chick embryo cell vaccine (PCECV) and Vero rabies vaccines (PVRV). this phase III clinical trial, we aimed to demonstrate safety immunogenic non-inferiority of compared with Essen healthy adult Chinese immunized PCECV (Rabipur®). study enrolled 825 subjects aged 18 50 years; serum samples were collected on Days 0, 7, 14, 42, at 13 months assess virus neutralizing...
Background: Mumps, a communicable, acute and previously well-controlled disease, has had recent occasional resurgences in some areas.Methods: A randomized, double-blind, controlled multistep phase I study of an F-genotype attenuated mumps vaccine produced human diploid cells was conducted. total 300 subjects were enrolled divided into 4 age groups: 16–60 years, 5–16 2–5 years 8–24 months. The groups immunized with one injection per subject. Three different doses the vaccine, (3.5 ± 0.25...
BackgroundIllegal commercial plasma and blood donation activities in the late 1980s early 1990s caused a large number of hepatitis C virus (HCV) infections rural areas China.MethodsA cross-sectional survey was carried out 2008, which all residents former village Hebei Province were invited for questionnaire interview testing HCV antibodies. Questionnaires administered to collect information about their personal status history, antibodies tested by enzyme immunoassay.ResultsOf 520 villagers...
Background: To assess the long-term protection conferred by plasma-derived hepatitis B vaccine at 20-31y after primary immunization during infancy in Chinese rural community.Method: Participants born between 1986 and 1996, who received a full course of vaccination with had no experience booster were enrolled. An epidemiological investigation was performed, blood samples collected to detect surface antigen (HBsAg), antibody (anti-HBs), core (anti-HBc). The positive rate HBsAg, anti-HBs,...
Since 2013, avian influenza A(H7N9) viruses have diversified into multiple lineages by dynamically reassorting with other viruses, especially H9N2, in Chinese poultry. Despite concerns about the pandemic threat posed H7N9 little is known biological properties of that may recruit internal genes from genetically distinct H9N2 circulating among wild birds. Here, we generated 63 reassortants derived an and a wild-bird-origin virus. Compared wild-type parent, 25/63 had increased pathogenicity...
Abstract Background Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution norovirus ORF2. These characteristics were found in hospital-based infections, whereas, asymptomatic are frequent and contribute significantly to transmission. Methods We conducted first molecular epidemiology analysis covering both derived from birth cohort study northern China....