A5002651107- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Cancer-related molecular mechanisms research
- Telecommunications and Broadcasting Technologies
- Animal Disease Management and Epidemiology
- Cancer, Lipids, and Metabolism
- Ginseng Biological Effects and Applications
- T-cell and Retrovirus Studies
- Error Correcting Code Techniques
- Inflammatory mediators and NSAID effects
- Bone Metabolism and Diseases
- Medicinal Plant Pharmacodynamics Research
- Virus-based gene therapy research
- Vector-Borne Animal Diseases
- Epigenetics and DNA Methylation
- Advanced Thermodynamic Systems and Engines
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
National Institutes for Food and Drug Control
2014-2025
China Banking Regulatory Commission
2025
Yunnan University
2023
Dalian Medical University
2020-2022
Xi'an University of Science and Technology
2022
The imbalance of bone homeostasis has become a major public medical problem amid the background an aging population, which is closely related to occurrence osteoporosis, osteoarthritis, and fractures. Presently, most drugs used in clinical treatment are bisphosphonates, calcitonin, estrogen receptor modulators, biological agents that inhibit resorption or parathyroid hormone analogs promote formation. However, there many adverse reactions. Therefore, it necessary explore potential drugs....
Background: We performed a phase I experiment in healthy teenage population Sui County, Henan Province, China. The trial was randomized, double-blind, and placebo-controlled. Methods: Ninety-six adolescents were randomly assigned three groups (high-dose, medium-dose, low-dose) to receive dose of the vaccine or placebo. patients monitored for adverse events (AEs) up 30 days after each 6 months all doses serious AEs (SAEs). All observed SAEs reported. Microneutralization assays used measure...
A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy, immunogenicity and safety of a novel trivalent live human-lamb reassortant rotavirus vaccine (LLR3) against gastroenteritis (RVGE). Healthy children aged 6–13 weeks were enrolled randomized (1:1) either 3 oral doses LLR3 or placebo according 0, 1, 2 month schedule. The objectives evaluate efficacy (VE) RVGE any-severity, severe (sRVGE) inpatient caused by...
A randomized, double-blind, placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine (HRV) against gastroenteritis (RVGE). total 6400 participants aged 6-12 weeks were enrolled randomly assigned either HRV (n = 3200) or placebo group. All subjects received three oral doses four apart. The (VE) RVGE caused by serotypes contained evaluated from 14 days after administration...
We conducted a phase I, randomized, double-blind, placebo-controlled trial including healthy adults in Sui County, Henan Province, China. Ninety-six were randomly assigned to one of three groups (high-dose, medium-dose, and low-dose) at 3:1 ratio receive vaccine dose or placebo. Adverse events up 28 days after each serious adverse 6 months all doses reported. Geometric mean titers seroconversion rates measured for anti-rotavirus neutralizing antibodies using microneutralization tests. The...
Abstract Gypenosides have anticancer activity against many cancers. Gypenoside LI is a gypenoside monomer from Gynostemma pentaphyllum , its pharmacological functions in melanoma not been reported. In this study, we found that had potent cytotoxic effect on cells. can induce intrinsic apoptosis along with S phase arrest. Furthermore, inhibited the colony formation ability of through inhibition Wnt/β‐catenin signaling pathway. Interestingly, also upregulation tumor suppressor miR‐128‐3p...
The oral hexavalent live human-bovine reassortant rotavirus vaccine (RV6) developed by Wuhan Institute of Biological Products Co., Ltd (WIBP) has finished a randomized, placebo-controlled phase III clinical trial in four provinces China 2021. trail demonstrated that RV6 high efficacy against the prevalent strains and is safe for use infants. During (2019–2021), 200 rotavirus-positive fecal samples from children with RV gastroenteritis (RVGE) were further studied. Using reverse...
A major contributor to older disability is osteoarthritis. Radix Angelicae Biseratae (known as Duhuo in China, DH, the dried rhizome of Angelica pubescens) and Dipsaci Xuduan XD, Dipsacus asper Wall) herb pair (DXHP) widely used treat osteoarthritis, but underlying molecular mechanisms still have not been revealed. This research aimed illustrate therapeutic mechanism DXHP against osteoarthritis through techniques network pharmacology docking.Gene targets for active ingredients were screened...
At present, low density parity check code (LDPC) has been widely used in channel coding and decoding because of its excellent performance, but with the increase length, complexity algorithm became higher higher. In view limitations rapid development artificial intelligence technology, it great research prospects to solve above problems through deep neural network. Therefore, this paper mainly focuses on design improvement LDPC process, proposes an model based DenseNet network structure,...
Objective To prepare a national evaluation reference of virus titer for live oral rotavirus (RV) vaccines. Methods A bulk qualified attenuated RV vaccine was mixed with preservative, packed into ampoules (1.0 ml/vial) and lyophilized. The the preparation determined by micro-cytopathic method 50% cell culture infective dose (CCID50) calculated Karber method. collaboratively evaluated in 3 different laboratories results were analyzed one way ANOVA least-significant difference test. In...
Rotavirus remains a major cause of diarrhea among 5-y-old children, and vaccination is currently the most effective economical measure. We conducted randomized, double-blind, placebo-controlled phase II clinical trial designed to determine dosage, immunogenicity, safety profile novel hexavalent rotavirus vaccine. In total, 480 eligible healthy infants, who were 6–12 weeks age at time randomization randomly allocated (1:1:1) receive 105.5 focus-forming unit (FFU) or 106.5FFU vaccine placebo...
Objective To develop detection methods for porcine circovirus type 1 (PCV1) — the adventitious agent in rotavirus vaccine contamination incident, African green monkey kidney cell (Vero cell). Methods Six days after PCV1 infection, virus replication and proliferation Vero cells were tested with qualitative PCR, quantitative PCR (qPCR), electron microscopy (EM) situ hybridization (ISH). Results PCR products amplified from PCV1-infected DNA extracts presented specific band agarose...
Objective To evaluate whether simultaneous vaccination with live attenuated polio vaccine affects the immunogenicity of rotavirus (RV) vaccine. Methods Rotarix produced by GlaxoSmithKline was used as research object. Two doses Rotarix were orally administered on day 0 and month 1, oral (OPV) 0, 1 2 according to national plan. Healthy infants aged 6 16 weeks randomly divided into two groups: interval group (Rotarix OPV vaccinated different days) same day). Serum samples collected 12,...
Accumulating evidence has proved that aberrant methylation of enhancers plays regulatory roles in gene expression for various cancers including lung adenocarcinoma (LUAD). In this study, the transcriptome and data The Cancer Genome Atlas (TCGA)-LUAD cohort were comprehensively analyzed with a five-step Enhancer Linking by Methylation/Expression Relationships (ELMER) process. Step 1: 131,371 distal (2 kb upstream from transcription start site) probes obtained. 2: 10,665 hypomethylated...