A5103008745- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Bone health and treatments
- Cancer, Lipids, and Metabolism
Yunnan University
2023
The imbalance of bone homeostasis has become a major public medical problem amid the background an aging population, which is closely related to occurrence osteoporosis, osteoarthritis, and fractures. Presently, most drugs used in clinical treatment are bisphosphonates, calcitonin, estrogen receptor modulators, biological agents that inhibit resorption or parathyroid hormone analogs promote formation. However, there many adverse reactions. Therefore, it necessary explore potential drugs....
A major contributor to older disability is osteoarthritis. Radix Angelicae Biseratae (known as Duhuo in China, DH, the dried rhizome of Angelica pubescens) and Dipsaci Xuduan XD, Dipsacus asper Wall) herb pair (DXHP) widely used treat osteoarthritis, but underlying molecular mechanisms still have not been revealed. This research aimed illustrate therapeutic mechanism DXHP against osteoarthritis through techniques network pharmacology docking.Gene targets for active ingredients were screened...