A5101878710- Cardiomyopathy and Myosin Studies
- Occupational Health and Safety Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Medicinal Plants and Neuroprotection
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Health and Disease Prevention
- Acupuncture Treatment Research Studies
- RNA and protein synthesis mechanisms
- Intracranial Aneurysms: Treatment and Complications
- ATP Synthase and ATPases Research
- Congenital Heart Disease Studies
- DNA Repair Mechanisms
- Viral Infections and Immunology Research
- Kruppel-like factors research
- Ideological and Political Education
- Genomics and Rare Diseases
- Cancer Research and Treatments
- Global Health and Surgery
- Social and Behavioral Studies
Jiading District Central Hospital
2025
Shanghai University of Medicine and Health Sciences
2025
Yunnan University of Traditional Chinese Medicine
2025
Beijing University of Chinese Medicine
2022-2024
University of California, Riverside
2024
Capital Medical University
2022-2024
Fudan University Shanghai Cancer Center
2023
Ministry of Education of the People's Republic of China
2023
Yunnan University
2019-2023
Second Xiangya Hospital of Central South University
2014-2022
Inflammation mediated by the peripheral infiltration of inflammatory cells plays an important role in intracerebral hemorrhage (ICH) induced secondary injury. Previous studies have indicated that regulatory T lymphocytes (Tregs) might reduce ICH-induced inflammation, but precise mechanisms contribute to injury remain unclear. Our results show number Tregs brain increases after ICH. Inducing deletion using a CD25 antibody or Foxp3DTR-mice increased neurological deficient scores (NDS), level...
Mitochondria in many types of cells are dynamically interconnected through constant fusion and fission, allowing for exchange mitochondrial contents repair damaged mitochondria. However, constrained by the myofibril lattice, ∼6,000 mitochondria adult mammalian cardiomyocyte display little motility, it is unclear how, if at all, they communicate with each other. By means target-expressing photoactivatable green fluorescent protein (PAGFP) matrix or on outer membrane, we demonstrated that...
Accumulating data suggest a link between alterations/deficiencies in cytoskeletal proteins and the progression of cardiomyopathy heart failure, although molecular basis for this remains unclear. Cypher/ZASP is protein localized sarcomeric Z-line. Mutations its encoding gene have been identified patients with isolated non-compaction left ventricular myocardium, dilated (DCM) hypertrophic cardiomyopathy. To explore role Cypher myocardium to better understand mechanisms by which mutations...
Background The escalating global incidence of polycystic ovary syndrome (PCOS) necessitates a thorough examination its epidemiological trends and sociodemographic correlations. Our study bridges this gap by analyzing the impact PCOS among women childbearing age (WCBA) from 1990 to 2021, aiming inform strategies for enhanced prevention management. Methods We extracted data Global Burden Disease Study 2021 (GBD 2021), focusing on burden aged 15–49 years. assessed incidence, prevalence,...
Abstract The CYP2C19 gene plays a detrimental role in the metabolism of clopidogrel. This study aimed to investigate association between polymorphisms and clinical efficacy clopidogrel therapy patients who have undergone carotid artery stenting (CAS). genotype screening was performed on 959 ischemic stroke patients. Of these patients, 241 had CAS were enrolled study. They all followed up for 1 year after stent surgery, primary end-points events. frequencies *2 *3 alleles among 31.80% 5.06%,...
Percardiac device closure of ventricular septal defects (VSDs) is considered as an alternative to surgical repair in certain patients; however, the safety and validity this technique subaortic VSD are unproven.A total 463 patients with underwent two different operative procedures. The clinical data were collected a retrospective analysis was performed.A 145 (90.06%) cases successfully occluded Group A, 16 (9.94%) converted open-heart surgery after occlusion procedure failure. A 302 B...
-Alkyl-2'-deoxyguanosine (
The whole exome sequencing (WES) with targeted gene analysis is an effective diagnostic tool for cardiomyopathy. early-onset sudden cardiac death (SCD) was commonly associated dilated cardiomyopathy (DCM) induced by pathogenic genetic mutations.In a Chinese Han family, the patient of 24 years old occurred and DCM died SCD ICD storms repetitive ventricular tachycardia/fibrillation (VT/F). Genomic DNA samples peripheral blood were conducted WES Sanger sequence. Then, we performed...
Cycling cells replicate their DNA during the S phase through a defined temporal program known as replication timing. Mutation frequencies, epigenetic chromatin states, and transcriptional activities are different for genomic regions that replicated early late in phase. Here, we found from ChIP-Seq analysis polymerase (Pol) κ is enriched early-replicating HEK293T cells. In addition, by feeding with N 2 -heptynyl-2′-deoxyguanosine followed click chemistry–based enrichment high-throughput...
Humans are exposed to DNA alkylating agents through endogenous metabolism, environmental exposure and cancer chemotherapy. The resulting alkylated adducts may elicit genome instability by perturbing replication transcription. R-loops regulate various cellular processes, including transcription, repair, telomere maintenance. However, unscheduled also recognized as potential sources of damage instability. In this study, employing fluorescence microscopy R-loop sequencing approaches, we...
Abstract Background Cryptococcal meningitis (CM) remains a leading cause of death in HIV-infected patients, despite advances CM diagnostic and therapeutic strategies. This study was performed with the aim to develop validate novel scoring model predict mortality risk patients (HIV/CM). Methods Data on HIV/CM inpatients were obtained from Multicenter Cohort China. Independent factors associated identified based data 2013 2017, for prediction established. The bootstrapping statistical method...
Abstract Background Inadequate preoperative management of chronic medications can place perioperative patients at risk and cause unnecessary delays in surgical procedures. This study aims to investigate the prevalence medication therapy problems (CMTPs) hospitalized assess relevance pharmacists’ interventions. Methods We conducted a retrospective pharmacist-led adult from November 2018 April 2019. The recorded drug-related (DRPs) were retrospectively reviewed categorized according...
Background: The optimal timing for initiation of antiretroviral therapy (ART) in HIV-positive patients with cryptococcal meningitis (CM) has not, as yet, been compellingly elucidated, research data concerning mortality risk and the occurrence immune reconstitution inflammatory syndrome (IRIS) this population remains inconsistent controversial. Method: present multicenter randomized clinical trial was conducted China who presented confirmed HIV/CM, were ART-naïve. Subjects stratified into...
The cardiovascular risk models and subclinical atherosclerotic indicators are both recommended for stratification. accordance between the incidence of atherosclerosis subjects with low moderate is unclear.Subjects have a lower compared high risk.Brachial-ankle pulse wave velocity (BaPWV) brachial flow-mediated dilation (BFMD) were measured in 421 without history disease (ASCVD) from October 2016 to January 2020. All classified into low, moderate, based on Framingham China-par...