A5102842758- Cardiac electrophysiology and arrhythmias
- RNA and protein synthesis mechanisms
- Ion channel regulation and function
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Gout, Hyperuricemia, Uric Acid
- Receptor Mechanisms and Signaling
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Genomics and Rare Diseases
- Pharmacological Receptor Mechanisms and Effects
Guangdong Academy of Medical Sciences
2019-2023
Guangdong Provincial People's Hospital
2019-2023
Southern Medical University
2023
The whole exome sequencing (WES) with targeted gene analysis is an effective diagnostic tool for cardiomyopathy. early-onset sudden cardiac death (SCD) was commonly associated dilated cardiomyopathy (DCM) induced by pathogenic genetic mutations.In a Chinese Han family, the patient of 24 years old occurred and DCM died SCD ICD storms repetitive ventricular tachycardia/fibrillation (VT/F). Genomic DNA samples peripheral blood were conducted WES Sanger sequence. Then, we performed...
There are country and regional variations in the prevalence of hyperuricaemia (HUA). The HUA non-valvular atrial fibrillation (NVAF) southern China is unknown.A cross-sectional study.A total 11 488 permanent residents aged 35 or older from urban rural areas Guangzhou, were enrolled. A questionnaire was used to compile each participant's demographic information relevant epidemiological factors for NVAF. All participants assessed using a panel blood tests single-lead 24-hour ECG.HUA defined as...
Abstract Background Brugada syndrome (Brs) and long QT (LQTs) are the most observed “inherited primary arrhythmia syndromes” “channelopathies”, which lead to sudden cardiac death. Methods Detailed clinical information of Brs LQTs patients was collected. Genomic DNA samples peripheral blood were conducted for whole-exome sequencing on Illumina HiSeq 2000 platform. Then, we performed bioinformatics analysis 200 genes susceptible arrhythmias cardiomyopathies. Protein interaction transcriptomic...
<b><i>Objective:</i></b> Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. About half sudden deaths from AMI are mainly because malignant ventricular arrhythmias (VA) after AMI. The sodium channel gene <i>SCN5A</i> potassium genes <i>KCNQ1</i> <i>KCNH2</i> have been widely reported to be genetic risk factors for arrhythmia including Brugada syndrome long QT (LQTS). A few studies the...
Abstract The infection of the coronavirus disease 2019 (COVID‐19) is often accompanied by pneumonia with both high incidence and mortality. Paxlovid commonly prescribed in patients mild normal within 5 days from symptom onset. Herein, we report a practically effective use compensatively COVID‐19 severe after typical case China. In this case, 75‐year‐old man was diagnosed complicated pulmonary bacterial infection. After treatment oxygen inhalation, Cefoperazone‐sulbactam ambroxol, fever upper...
Objective: A complex familial arrhythmia syndrome was identified in a Chinese Han family, characterized by sick sinus syndrome, progressive conduction block, atrial fibrillation, standstill and Brugada syndrome. The underlying mechanism associated with the genetic mutation investigated. Methods: Genetic analysis conducted for probands coding splicing regions of genes susceptible to cardiac diseases. stable cell lines overexpressing wild-type (WT) or mutant SCN5A gene were generated HEK293T...