A5050409339- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Ion Channels and Receptors
- Nitric Oxide and Endothelin Effects
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience and Neural Engineering
- Renin-Angiotensin System Studies
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Advanced Glycation End Products research
- Extracellular vesicles in disease
- Inflammasome and immune disorders
- ATP Synthase and ATPases Research
- Connexins and lens biology
Guangdong Provincial People's Hospital
2009-2025
Guangdong Academy of Medical Sciences
2016-2025
Southern Medical University
2013-2024
South China University of Technology
2017-2024
Shanghai Academy of Educational Sciences
2023
Jiangxi Science and Technology Normal University
2021
Jiangxi Normal University
2021
Guangzhou Medical University
2011-2020
Third Affiliated Hospital of Guangzhou Medical University
2019-2020
Guangdong General Hospital
2009-2019
Stem cell-based therapy is a promising intervention for ischemic heart diseases. However, the functional integrity of stem cells impaired in an environment. Here, we report novel finding that heat shock significantly improves Sca-1(+) cell survival environment by regulation triangle: factor 1 (HSF1), HSF1/miR-34a, and protein 70 (HSP70). Initially prove HSP70 key chaperone-mediating cytoprotective effect then establish miR-34a as direct repressor HSP70. We found was downregulated shocked...
Abstract Mitochondrial dysfunction and impaired Ca 2+ handling are involved in the development of diabetic cardiomyopathy (DCM). Dynamic relative protein 1 (Drp1) regulates mitochondrial fission by changing its level phosphorylation, Orai1 (Ca release-activated calcium channel 1) is important for increase entry into cardiomyocytes. We aimed to explore mechanism Drp1 cardiomyocyte hypertrophy caused high glucose (HG). found that Zucker fat rats induced administration a high-fat diet develop...
Abstract Pyroptosis plays a crucial role in sepsis, and the abnormal handling of myocyte calcium (Ca 2+ ) has been associated with cardiomyocyte pyroptosis. Specifically, inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is Ca release channel endoplasmic reticulum (ER). However, specific IP3R2 sepsis-induced cardiomyopathy (SIC) not yet determined. Thus, this study aimed to investigate underlying mechanism by which channel-mediated signaling contributes lipopolysaccharide (LPS)—induced...
Despite numerous studies identifying specific microRNA (miRNA) expression profiles associated with atrial fibrillation (AF), changes in plasma miRNA pre- and post-operative AF patients who have received catheter ablation, remain poorly characterized. This study aimed to reveal disease-related biomarkers by detecting patients, examining the levels of AF-specific miRNAs after order help gauge therapeutic effects assess prognosis. A total 100 Han Chinese had healthy individuals, were...
Diabetes mellitus (DM) is a common chronic metabolic disease caused by significant accumulation of advanced glycation end products (AGEs). Atrial fibrillation (AF) cardiovascular complication DM. Here, we aim to clarify the role and mechanism atrial myocyte senescence in susceptibility AF diabetes. Rapid transesophageal pacing was used monitor mice AF. Whole-cell patch-clamp employed record action potential (AP) ion channels single HL-1 cell mouse myocytes. More importantly, anti-RAGE...
Abstract Background: The nucleotide-binding oligomerization domain [NOD-], leucine-rich repeats [LRR-], and Pyrin domain-containing protein 3 (NLRP3) inflammasome plays an essential role in hypertension-related atrial fibrillation (AF). p300 is involved cardiovascular inflammation. In this study, we aimed to investigate the of NLRP3 activation its subsequent impact on I kur current angiotensin II (Ang II)-induced HL-1 cells Ang II-infused mice. Methods: Expression levels p300, Kv1.5, left...
Desmosomes and gap junctions are situated in the intercalated disks of cardiac muscle maintain integrity mechanical coupling electrical impulse conduction between cells. The desmosomal plakin protein, desmoplakin (DSP), also plays a crucial role stability these interconnected components as well junction connexin proteins. In addition to cell‑to‑cell junctions, other molecules, including voltage‑gated sodium channels (Nav1.5) present disk support contraction muscle. Mutations genes encoding...
Hypertension is a major cardiovascular risk factor for atrial fibrillation (AF) worldwide. However, the role of mechanical stress caused by hypertension on downregulating L-type calcium current (I Ca,L ), which vital AF occurrence, remains unclear. Therefore, aim present study was to investigate Piezo1, mechanically activated ion channel, in decrease I response high hydrostatic pressure (HHP, one principal stresses) at 40 mmHg, and elucidate underlying pathways. Experiments were conducted...
Atrial fibrosis induced by aging is one of the main causes atrial fibrillation (AF), but potential molecular mechanism not clear. Acetyltransferase p300 participates in cellular senescence and fibrosis, which might be involved age-related fibrosis. Four microarray datasets generated from tissue AF patients sinus rhythm (SR) controls were analyzed to find possible relationship (EP300) with And then, biochemical assays vivo electrophysiological examination performed on older patients, mice,...
The objective of the present study is to analyze epidemiological profile patients with abnormal valvular structure and function highlight etiological spectrum management heart disease (VHD) in a single cardiovascular center Southern China five years.The retrospective included 19,428 consecutive (9,441 men 9,987 women mean age 52.03±20.50 years) who were screened by transthoracic echocardiography (TTE) or transesophageal (TEE) at in-patient department Guangdong General Hospital from January...
In the early stage of diabetes, cardiac ejection fraction is preserved, despite existence subclinical dysfunction to some extent. However, detailed phenotype this and underlying mechanism remain unclear. To improve our understanding issue, we used low-dose STZ high-fat diet induce type 2 diabetic models in rats. The effects associated with stages disease were analyzed. mellitus (T2DM) SD rats induced through 30 mg/kg diet. Two-dimensional spackle-tracking echocardiography (STE) dobutamine...
Hypertension is a main risk factor for atrial fibrillation, but the direct effects of hydrostatic pressure on fibrosis are still unknown. The present study investigated whether responsible fibrosis, and addressed potential role Smad pathway in this pathology. Biochemical assays were used to regulation expression fibrotic factors spontaneously hypertensive rats (SHRs) Wistar rats, cardiac fibroblasts (CFs) cultured under standard (0 mmHg) elevated (20, 40 pressure. Levels protein...
This study was designed to identify the pathogenic mutation in a Chinese family with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) using whole genome sequencing (WGS).Probands II:1 and II:2 underwent routine examinations for diagnosis. Genomic DNA extracted from peripheral blood of members analyzed WGS. A total 60,285 single-nucleotide polymorphisms (SNP) 13,918 insertions/deletions (InDel) occurring exonic regions genes predisposing cardiomyopathies arrhythmias were...
Atrial fibrosis is the fundamental characteristic of structural pathology associated with atrial fibrillation (AF). Inflammation can contribute to fibrosis, engendering AF. The present study aimed investigate role macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, in regulation proliferation and function cardiac fibroblasts (CFs). Biochemical assays were performed examine expression extracellular matrix (ECM) human tissues, ECM induced by MIF CFs. ECM, including collage...
Summary Increasing evidence indicates that inflammation contributes to the initiation and perpetuation of atrial fibrillation ( AF ). Although tumour necrosis factor TNF )‐ α levels are increased in patients with , role ‐ pathogenesis remains unclear. Besides L‐type Ca 2+ currents I C a,L ), T‐type a,T ) also plays an important . This study was designed use whole‐cell voltage‐clamp technique biochemical assays explore if is involved through regulating myocytes. It found compared sinus rhythm...
The T-type Ca(2+) current (I(Ca,T)) plays an important role in the pathogenesis of atrial fibrillation (AF). present study sought to investigate macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, regulation channels (TCCs) myocytes. We used whole-cell voltage-clamp technique and biochemical assays expression I(Ca,T) Gene levels α1G α1H subunit TCCs were decreased human tissue patients with AF. In cultured atrium-derived myocytes (HL-1 cells), mouse recombinant MIF (20 or...