A5103091618- Asthma and respiratory diseases
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Multiple Myeloma Research and Treatments
- Respiratory viral infections research
- Immune Response and Inflammation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Respiratory and Cough-Related Research
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Inflammasome and immune disorders
- Cardiac Fibrosis and Remodeling
- Pediatric health and respiratory diseases
- Hematopoietic Stem Cell Transplantation
- Advanced Breast Cancer Therapies
- T-cell and B-cell Immunology
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Click Chemistry and Applications
- IL-33, ST2, and ILC Pathways
- Nanoparticle-Based Drug Delivery
- Cardiovascular Disease and Adiposity
- Ferroptosis and cancer prognosis
Guangdong Academy of Medical Sciences
2023-2025
Guangdong Provincial People's Hospital
2023-2025
Hebei General Hospital
2024
Johns Hopkins Medicine
2017
Johns Hopkins University
1998-2017
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2013
The University of Texas MD Anderson Cancer Center
2011
University of Arkansas for Medical Sciences
1992-1995
John L. McClellan Memorial Veterans Hospital
1995
Geriatric Research Education and Clinical Center
1995
Atopic asthma is characterized by inflammatory responses of the airway and associated with up-regulation Th2 cytokines, notably IL-4 IL-5. A recently described human cytokine, IL-13, a potent in vitro modulator various cell types, including monocytes, B cells, endothelial cells. Similar to IL-4, it also involved induction IgE synthesis. However, vivo expression function IL-13 its relation disease remain be defined. Using segmental allergen challenge model, we have examined bronchoalveolar...
Abstract Background: The nucleotide-binding oligomerization domain [NOD-], leucine-rich repeats [LRR-], and Pyrin domain-containing protein 3 (NLRP3) inflammasome plays an essential role in hypertension-related atrial fibrillation (AF). p300 is involved cardiovascular inflammation. In this study, we aimed to investigate the of NLRP3 activation its subsequent impact on I kur current angiotensin II (Ang II)-induced HL-1 cells Ang II-infused mice. Methods: Expression levels p300, Kv1.5, left...
Viral infections increase vagally mediated reflex bronchoconstriction. Decreased function of inhibitory M2 muscarinic receptors on the parasympathetic nerve endings is likely to contribute increased acetylcholine release. In this study, we used cultured airway neurons determine effects parainfluenza virus and interferon (IFN)-gamma release, receptor function, gene expression. control cultures, electrically stimulated release when were blocked using atropine (10(-)5 M) decreased these...
Allergic inflammation is a common feature of asthma and may contribute to both development perpetuation disease. The interaction antigen-presenting cells (APC) with sensitized helper T lymphocytes (TC) producing Th2 cytokines determine the inflammatory response. Recruitment APC TC lung during allergic responses has been demonstrated, but functional studies in humans have limited.This study examined function accumulating at sites after segmental allergen challenge (SAC).Fifteen patients...
Macrophages adopt diverse activation states depending on the microenvironment. Recently, stromal cells have been demonstrated to be organizers of Here, using splenic mimic microenvironment in vivo, we show that spleen can programme bone marrow-derived mononuclear differentiate and polarize into a novel macrophage subset. These differentiated macrophages (Diff-Mφ) exhibited pronounced production IL-10, IL-6 TNF-α, but diminished IL-12 response LPS. The generation Diff-Mφ depended cell-cell...
Abstract As an independent risk factor of atrial fibrillation (AF), hypertension (HTN) can induce fibrosis through cyclic stretch and hydrostatic pressure. The mechanism by which high pressure promotes is unclear yet. p300 p53/Smad3 play important roles in the process fibrosis. This study investigated whether activating p300/p53/Smad3 pathway. Biochemical experiments were used to expression pathway left appendage (LAA) tissues patients with sinus rhythm (SR), AF, AF + HTN, C57/BL6 mice,...