A5038588938- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Magnolia and Illicium research
- 14-3-3 protein interactions
- Endoplasmic Reticulum Stress and Disease
- Oxidative Organic Chemistry Reactions
- Carbon Dioxide Capture Technologies
- Cancer, Lipids, and Metabolism
- Chemical Looping and Thermochemical Processes
- Eicosanoids and Hypertension Pharmacology
- Chinese history and philosophy
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- Atmospheric Ozone and Climate
- Microbial Natural Products and Biosynthesis
- Cancer-related Molecular Pathways
- Atmospheric chemistry and aerosols
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Education and Work Dynamics
Weifang Medical University
2023-2025
Paul Scherrer Institute
2016-2025
ETH Zurich
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Tongji University
2024
Tongji Hospital
2024
Xiamen Medical College
2024
Guangzhou University of Chinese Medicine
2024
China National Pharmaceutical Group Corporation (China)
2024
Chongqing University
2020-2023
The huge consumption of fossil fuels leads to excessive CO2 emissions, and its reduction has become an urgent worldwide concern. combination renewable energies with battery energy storage, carbon capture, utilization, storage are well acknowledged as two major paths in achieving neutrality. However, the former route faces discard problem a large amount lithium-ion batteries (LIBs) due their limited lifespan, while it is costly obtain effective CO2-capturing materials put latter into...
Abstract The proteasome inhibitor PS-341 (bortezomib or Velcade), an approved drug for treatment of patients with multiple myeloma, is currently being tested in clinical trials against various malignancies, including lung cancer. Preclinical studies have shown that induces apoptosis and enhances tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)–induced human cancer cells undefined mechanisms. In the present study, we show induced caspase-8–dependent apoptosis, cooperated TRAIL...
The substantial heterogeneity and hierarchical organization in liver cancer support the theory of stem cells (LCSCs). However, relationship between chronic hepatic inflammation LCSC generation remains obscure. Here, we observed a close correlation aggravated progenitor cell (LPC) propagation cirrhotic rats exposed to diethylnitrosamine. LPCs isolated from rat initiated subcutaneous cancers nonobese diabetic/severe combined immunodeficient mice, suggesting malignant transformation toward...
Oxidation of bromide in aqueous environments initiates the formation molecular halogen compounds, which is important for global tropospheric ozone budget. In bulk, oxidation by involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy measurements that provide direct experimental evidence ozonide and establish its propensity solution-vapour interface. Theoretical calculations support these findings, showing water stabilizes lowers energy...
Abstract Objective Non-small cell lung cancer (NSCLC) often exhibits resistance to radiotherapy, posing significant treatment challenges. This study investigates the role of SMAD3 in NSCLC, focusing on its potential influencing radiosensitivity via ITGA6/PI3K/Akt pathway. Methods The utilized gene expression data from GEO database identify differentially expressed genes related radiotherapy NSCLC. Using GSE37745 dataset, prognostic were identified through Cox regression and survival...
The proteasome, a key component of the ubiquitin-proteasome pathway, has emerged as an important cancer therapeutic target. PS-341 (also called Bortezomib or Velcade) is first proteasome inhibitor approved for newly diagnosed and relapsed multiple myeloma currently being tested in many clinical trials against other types cancers. One proposed mechanism by which exerts its anticancer effect inactivation nuclear factor-kappaB (NF-kappaB) through prevention IkappaB(alpha) degradation. In this...
Abstract Background Azithromycin is a member of macrolide antibiotics, and has been reported to inhibit the proliferation cancer cells. However, underlying mechanisms are not fully elucidated. Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) selectively targets tumor cells without damaging healthy In present study, we examined whether azithromycin synergistic with TRAIL, if so, in colon cancers. Methods HCT‐116, SW480, SW620 DiFi were treated azithromycin, purified or their...
Raistrickindole A (1), a new indole diketopiperazine alkaloid containing an unusual pyrazino[1′,2′:2,3][1,2]oxazino[6,5-b]indole tetraheterocyclic ring system, benzodiazepine derivative, raistrickin (2), and the known haenamindole (3) sclerotigenin (4) were isolated from marine-derived fungus Penicillium raistrickii IMB17-034. Their structures elucidated by extensive spectroscopic analyses TDDFT calculations of NMR ECD data. Compounds 1 2 showed inhibitory activities against hepatitis C virus.
Abstract Multi‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic (PDT) promising modality that can circumvent MDR and synergize with chemotherapies, based on the generation reactive oxygen species (ROS) by photosensitizers. However, overproduction glutathione (GSH) cells scavenges ROS restricts efficacy PDT. Additionally, side effects normal tissues are unavoidable after PDT treatment. Here, to develop organic systems deliver effective anticancer chemotherapy...
Summary Background The angiotensin (Ang) converting enzyme 2 ( ACE 2)/Ang‐(1‐7)/Mas receptor pathway is an important component of the renin–angiotensin system and has been suggested to exert beneficial effects in ischemic stroke. Aims This study explored whether 2/Ang‐(1‐7)/Mas a protective effect on cerebral injury this affected by age. Methods We used three‐month eight‐month transgenic mice with neural over‐expression SA ) their age‐matched nontransgenic NT) controls. Neurological deficits...
Diabetes mellitus (DM) is a common chronic metabolic disease caused by significant accumulation of advanced glycation end products (AGEs). Atrial fibrillation (AF) cardiovascular complication DM. Here, we aim to clarify the role and mechanism atrial myocyte senescence in susceptibility AF diabetes. Rapid transesophageal pacing was used monitor mice AF. Whole-cell patch-clamp employed record action potential (AP) ion channels single HL-1 cell mouse myocytes. More importantly, anti-RAGE...
The ALPK1 (alpha-kinase 1)-TIFA (TRAF-interacting protein with fork head-associated domain)-TRAF6 signaling pathway plays a pivotal role in regulating inflammatory processes, TIFA and TRAF6 serving as key molecules this cascade. Despite its significance, the functional mechanism of TIFA-TRAF6 remains incompletely understood. In study, we unveil that undergoes liquid-liquid phase separation (LLPS) induced by response to adenosine diphosphate (ADP)-β-D-manno-heptose (ADP-Hep) recognition. is...
Halide ions in oceans and sea-spray aerosol particles are an important source of reactive halogen species the atmosphere that impact ozone budget radiative balance. The multiphase cycling is linked to abundance halide at aqueous solution–air interface. Ubiquitously present surface-active organic compounds may affect interfacial ions. Here, we use liquid jet X-ray photoelectron spectroscopy molecular dynamics (MD) simulations assess surfactants with different headgroups on bromide sodium Core...