A5100379658- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Peptidase Inhibition and Analysis
- Porphyrin Metabolism and Disorders
- Gout, Hyperuricemia, Uric Acid
- Nerve injury and regeneration
- Iron Metabolism and Disorders
- Heat shock proteins research
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA regulation and disease
- Retinoids in leukemia and cellular processes
- Folate and B Vitamins Research
- CRISPR and Genetic Engineering
- Gut microbiota and health
- Circular RNAs in diseases
Shanghai First People's Hospital
2025
Shanghai Jiao Tong University
2025
Ningbo University
2018-2024
Yan'an University
2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Tsinghua University
2024
Jiangxi Maternal and Child Health Hospital
2024
Shanghai First Maternity and Infant Hospital
2024
Abstract Emerging evidence suggests that active DNA demethylation machinery plays important epigenetic roles in mammalian adult neurogenesis; however, the precise molecular mechanisms and critical functional players of this process remain largely unexplored. Ten–eleven translocation (Tet) proteins convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) its downstream derivatives. Here we show 5hmC is elevated during differentiation neural stem cells (aNSCs), Tet2 primarily...
Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases. However, the roles of regulating neurogenesis remain largely unknown. Here, we show that deficiency or depletion adult neural stem/progenitor cells (aNSPCs) leads to diminishment aNSPC pool aberrant consequently impairs cognitive mice. RNA sequencing reveals alters transcription genes relating cell cycle, neurogenesis, neuronal development....
Maternal obesity increases the risk of and metabolic disorders (MDs) in offspring, which can be mediated by gut microbiota. Phlorizin (PHZ) improve dysbiosis positively affect host health; however, its transgenerational benefits remain largely unclear. This study aimed to investigate potential maternal PHZ intake attenuating adverse impacts a high-fat diet on obesity-related MDs dams offspring. The results showed that reduced HFD-induced body weight gain fat accumulation improved glucose...
Histone deacetylase inhibitors (HDACi's) are emerging as promising anticancer drugs alone or in combination with chemotherapy radiotherapy agents. Previous research suggests that HDACi's have a high degree of selectivity for killing cancer cells, but little is known regarding the impact different cellular contexts on HDACi treatment. It likely molecular mechanisms involve processes depend chromatin template, such DNA damage and repair. We sought to establish connection between sodium...
OBJECTIVES: Immunoglobulin A nephropathy is the most common cause of chronic renal failure among primary glomerulonephritis patients.The ability to diagnose immunoglobulin remains poor.However, biopsy an inconvenient, invasive, and painful examination, no reliable biomarkers have been developed for use in routine patient evaluations.The aims present study were identify patients, useful establish a human metabolic profile.METHODS: Serum samples collected from patients who not using...
The ALPK1 (alpha-kinase 1)-TIFA (TRAF-interacting protein with fork head-associated domain)-TRAF6 signaling pathway plays a pivotal role in regulating inflammatory processes, TIFA and TRAF6 serving as key molecules this cascade. Despite its significance, the functional mechanism of TIFA-TRAF6 remains incompletely understood. In study, we unveil that undergoes liquid-liquid phase separation (LLPS) induced by response to adenosine diphosphate (ADP)-β-D-manno-heptose (ADP-Hep) recognition. is...
The purpose of this research was to study the roles chloride intracellular channel protein 1 (CLIC1) and heat shock 27 (HSP27) in clinical pathology lung adenocarcinoma explore whether expression CLIC1 HSP27 can be used as independent factors for prediction recurrence prognosis after radical resection adenocarcinoma. One hundred three paraffin sections tissues were collected, detected these tumors using immunohistochemistry. correlation two proteins with clinicopathological parameters...
Previous studies have suggested that increased opioid receptor κ1 (OPRK1) and δ1 (OPRD1) methylation levels are involved in Alzheimer's disease (AD). In the present study, of two genes, µ1 (OPRM1) related nociceptin 1 (OPRL1), were analyzed for their association with AD. Gene measured using bisulfite pyrosequencing DNA samples derived from blood 51 AD patients 63 controls. The results indicated there significantly elevated promoter OPRM1 OPRL1 (OPRM1: P=0.007; OPRL1: P=2.987x10‑6)....
Abstract Abnormal expression of Ten eleven translocation‐2 (Tet2) contributes to the pathogenesis Alzheimer's disease (AD). However, date, role Tet2 in modulating neuronal morphology upon amyloid‐β (Aβ)‐induced neurotoxicity has not been shown a mouse model AD. Here, we have developed injured hippocampal neurons induced by Aβ 42 oligomers vitro. We also investigated using recombinant plasmids‐induced inhibition or over‐expression. found that reduced exacerbated damage, whereas increased was...
Previous studies imply that telocytes may have a protective effect on fibrosis in various organs, including the liver, colon, and heart. The of renal remains unknown. Herein, this study was designed to investigate potential mechanisms involved.In unilateral ureteral obstruction (UUO)-induced model, were injected via tail vein every other day for 10 days. degree damage determined using histological assessment. expression collagen I, fibronectin, epithelial-mesenchymal transition markers,...
M1-polarized macrophages can improve the body’s immune function. This study aimed to explore mechanism of Platycodon grandiflorus polysaccharide (PGPS t ) degrading SOCS1/2 protein through autophagy and promoting M1 polarization in 3D4/21 cells. Immunoprecipitation, confocal laser scanning microscopy, flow cytometry, intracellular co-localization were used detect expression related phenotypic proteins cytokines The results showed that PGPS significantly promoted mRNA IL-6, IL-12, TNF-α...
Background. DNA demethylation, the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), plays important roles in diverse biological processes multiple diseases by regulating gene expression. Methods. In this study, utilizing dot blot, immunofluorescence staining, qRT-PCR, we studied expression pattern Tets, enzymes governing levels 5hmC, 5fC, 5caC during postnatal neuronal development mice. Results. It was found that...
Abnormal modification of 5-hydroxymethylcytosine (5hmC) is closely related to the occurrence Alzheimer's disease (AD). However, role 5hmC and its writers, ten-eleven translocation (Tet) proteins, in regulating pathogenesis AD remains largely unknown. We detected a significant decrease Tet2 levels hippocampus aged APPswe/PSEN1 double-transgenic (2×Tg-AD) mice that coincides with abundant amyloid-β (Aβ) plaque accumulation. On this basis, we examined reduction expression at early stages, which...
Abstract Myrosinases are β-thioglucoside glucosidases that unique to the Brassicales order. These enzymes hydrolyze glucosinolates produce compounds have direct antibiotic effects or function as signaling molecules in plant immune system, protecting plants from pathogens and insect pests. However, of jasmonic acid (JA), a hormone is crucial for disease resistance, on myrosinase activity remain unclear. Here, we systematically studied JA explored associated internal transcriptional regulation...