A5017564910- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Atrial Fibrillation Management and Outcomes
- Potassium and Related Disorders
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Human Pose and Action Recognition
- RNA modifications and cancer
- 3D Shape Modeling and Analysis
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Pulmonary Hypertension Research and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiomyopathy and Myosin Studies
- Cancer Immunotherapy and Biomarkers
- Lipoproteins and Cardiovascular Health
- Robot Manipulation and Learning
- Congenital Heart Disease Studies
- Advanced Neural Network Applications
- Breast Implant and Reconstruction
- Chemotherapy-induced cardiotoxicity and mitigation
Shanghai First People's Hospital
2025
Shanghai Jiao Tong University
2025
Beijing Hospital
2025
Peking Union Medical College Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2024
Microsoft Research (United Kingdom)
2023-2024
Fu Wai Hospital
2022-2023
Weatherford College
2023
Abstract Background Red blood cell distribution width (RDW) and N‐terminal pro brain natriuretic peptide (NT‐proBNP) may predict the prognosis of heart failure (HF). However, impact combined RDW NT‐proBNP levels as a prognostic marker HF remains unclear significance this combination at various time‐points has not been sufficiently studied. Hypothesis can in with improves value. Methods Patients admitted to care unit Fuwai Hospital CAMS&PUMC (Beijing, China) diagnosis from November 2008...
Intrauterine adhesion (IUA) refer to persistent inflammation and fibrosis due damaged or infected endometrium eventually lead dysfunction. This study aimed explore the therapeutic effects of exosomes (Exos) derived from placental mesenchymal stem cells (PMSCs) on endometrial repair in a rat model IUA elucidate underlying molecular mechanisms. PMSCs were characterized using flow cytometry differentiation assays (osteogenic, adipogenic, chondrogenic). Exos isolated via ultracentrifugation...
Background Lower cholesterol levels are associated with increased mortality in heart failure (HF) patients. Remnant corresponds to all not found high-density lipoprotein (HDL) and low-density (LDL). The prognostic role of remnant HF remains unknown. Objective To reveal the relationship between baseline level all-cause Methods This study enrolled 2,823 patients hospitalized for HF. Kaplan–Meier analysis, Cox regression, C-statistic, net reclassification improvement (NRI), integrated...
Abstract Aims Inflammatory biomarkers, including CRP, the neutrophil‐to‐lymphocyte ratio (NLR), and neutrophil‐to‐eosinophil (NER), may predict outcomes in cancer. However, their value immune checkpoint inhibitor (ICI) therapy‐associated cardiotoxicity remains elusive. We aimed to characterize relationship of inflammatory markers with severity ICI‐related cardiotoxicities (iRCs) prognosis among patients iRCs. Methods Patients who were diagnosed iRCs between January 2019 December 2021...
This study aimed to investigate the predictive value of Big endothelin-1(ET-1) for left ventricular reverse remodeling (LVRR) and prognosis in patients with dilated cardiomyopathy (DCM). Patients DCM a ejection fraction (LVEF) ≤ 50% from 2008 2017 were included. LVRR was defined as LVEF increased by at least 10% or follow-up minimum improvement 5%; meanwhile, index end-diastolic diameter (LVEDDi) decreased LVEDDi ≤33 mm/m2. The composite outcome prognostic analysis consisted death heart...
Despite the emerging prevalence of left ventricular (LV) thrombus in dilated cardiomyopathy (DCM), clinical characteristics, management, and disease prognosis are poorly studied. We aim to assess efficacy/safety profile direct oral anticoagulants (DOACs) compared warfarin by evaluating evolution, risk for stroke systemic embolism (SSE), heart failure (HF) rehospitalization, all-cause mortality, major adverse cardiovascular events (MACEs), determine impact evolution on events. performed a...
Traditional methods of reconstructing 3D human pose and mesh from single images rely on paired image-mesh datasets, which can be difficult expensive to obtain. Due this limitation, model scalability is constrained as well reconstruction performance. Towards addressing the challenge, we introduce Mesh Pre-Training (MPT), an effective pre-training strategy that leverages large amounts MoCap data effectively perform at scale. We use MoCap-generated heatmaps input representations regression...
Abstract Aims Mildly dilated cardiomyopathy (MDCM) was characterized as a subset of (DCM) with systolic dysfunction and modest ventricular dilatation, which the prognostic studies were limited. We aimed to compare value N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) high‐sensitivity C‐reactive protein (hs‐CRP) between MDCM DCM. Methods results retrospectively included hospitalized patients diagnosed DCM left ejection fraction ≤ 50% at Fuwai Hospital from 2006 2017. defined...
The prognostic significance of D-dimer in hospitalized heart failure (HF) patients is incompletely characterized. We aimed to assess the association levels on admission with adverse events at follow-up HF across all ejection fraction (EF) phenotypes.Consecutive from December 2006 2017 for and EF values available (n = 1795) were enrolled. Associations between all-cause death examined 1-year follow-up. Median age was 57 years, 73.4% male, majority (72.1%) New York Heart Association Classes...
Afterload-related cardiac performance (ACP), a diagnostic parameter for septic cardiomyopathy, integrates both and vascular effects could predict prognosis in shock.
Background Machine‐learning‐based prediction models (MLBPMs) have shown satisfactory performance in predicting clinical outcomes patients with heart failure reduced and preserved ejection fraction. However, their usefulness has yet to be fully elucidated mildly This pilot study aims evaluate the of MLBPMs a fraction cohort long‐term follow‐up data. Methods Results A total 424 were enrolled our study. The primary outcome was all‐cause mortality. Two feature selection strategies introduced for...
The aim of this study was to investigate the clinical characteristics and prognosis patients hospitalized with heart failure preserved ejection fraction (HFpEF) low N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Seven hundred ninety consecutive HFpEF from 2006 2017 were enrolled. Clinical outcomes compared between NT-proBNP group (<300 ng/L) elevated (≥300 ng/L). 108 (13.7%) presented Age, body mass index, atrial fibrillation, New York Heart Association functional class,...
Abstract Background Various randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas improves survival in patients with axillary node-positive breast cancer. Controversy exists as whether internal mammary node (IMN) region is an essential component of irradiation. Available data on benefit IMN irradiation (IMNI) are conflicting. The patient populations enrolled previous studies were heterogeneous most conducted before...
Abstract Aims Evidence of the prognostic value high‐sensitivity troponin in patients with non‐ischaemic heart failure (NIHF) is scarce. This study aimed to assess predictive cardiac I (hs‐cTnI) NIHF patients. Methods Hs‐cTnI was measured at baseline 650 admitted Heart Failure Center. The hs‐cTnI assessed based on a well‐established model (including age, sex, New York Association class, left ventricular ejection fraction, haemoglobin, sodium, estimated glomerular filtration rate, diabetes...
Abstract Aim To explore the relationship between serum sodium level on admission and all‐cause mortality in HF patients. Design A single‐center retrospective cohort study. Methods Patients hospitalized with at Heart Failure Center, Fuwai Hospital, from November 2008 to 2018 were enrolled. Results total of 3649 patients included, mean was 137.19 ± 4.36 mmol/L, a range 115.6 160.9 mmol/L. During median follow‐up 1101 days, occurred 1413 (38.7%) hospital survivors. After adjustment for age,...
We present a unified framework for camera-space 3D hand pose estimation from single RGB image based on implicit representation. As opposed to recent works, most of which first adopt holistic or pixel-level dense regression obtain relative and then follow with complex second-stage operations global root scale recovery, we propose novel scheme estimate via point-wise voting in camera frustum. Through direct modeling domain inspired by Pixel-aligned Implicit Functions detailed reconstruction,...
Heart failure (HF) patients are in a hypercoagulable state that predisposes them to an intracardiac thrombus. We aim assess the clinical features of with HF and thrombus.Patients diagnosed thrombus were enrolled this study. Patients' demographics, comorbidities, laboratory tests, cardiac imaging parameters recorded. Baseline characteristics described; relationship between location underlying diseases, New York Association (NYHA) class, left ventricular ejection fraction (LVEF) analyzed;...
Right ventricular (RV)-pulmonary arterial uncoupling is the consequence of increased afterload and/or decreased RV contractility. However, combination elastance (Ea) and end-systolic (Ees)/Ea ratio to assess function unclear. We hypothesized that both could comprehensively refine risk stratification. The median Ees/Ea (0.80) Ea (0.59 mmHg/mL) were used classify 124 patients with advanced heart failure into four groups. systolic pressure differential was defined as (ESP) minus...
Background: To assess the link between serum potassium (K+) and all-cause mortality in hospitalized heart failure (HF) patients. Methods: Hospitalized HF patients (n = 3114) were analyzed at Fuwai Hospital Heart Failure Center. Before discharge, divided into four groups according to K+ level quartiles: ≤3.96 mmol/L (Q1), 3.96 < ≤ 4.22 (Q2), 4.52 (Q3), >4.52 (Q4). At 90 days, 2 years, maximal follow-up, was primary outcome. Results: Patients with Q4 group had worse cardiac function,...