Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association increased risk of venous thromboembolism (VTE), but results these studies not consistent. We aimed to conduct a meta-analysis assess the relationship between TF-bearing and VTE in cancer. PubMed, Web Science EMBASE Databases were systematically retrieved up to1th June 2017. Two case-control four cohort met entry requirements this analysis. The summary odd ratio (OR) estimated by random effect model. overall...

Abstract Aims Inflammatory biomarkers, including CRP, the neutrophil‐to‐lymphocyte ratio (NLR), and neutrophil‐to‐eosinophil (NER), may predict outcomes in cancer. However, their value immune checkpoint inhibitor (ICI) therapy‐associated cardiotoxicity remains elusive. We aimed to characterize relationship of inflammatory markers with severity ICI‐related cardiotoxicities (iRCs) prognosis among patients iRCs. Methods Patients who were diagnosed iRCs between January 2019 December 2021...

Background Immune checkpoint inhibitors (ICIs) combined with angiogenesis (AGIs) have become increasingly available for multiple types of cancers, although the cardiovascular safety profiles this combination therapy in real-world settings not been elucidated to date. Therefore, we aimed comprehensively investigate toxicity ICIs AGIs comparison alone. Methods The Food and Drug Administration Adverse Event Reporting System (FAERS) database from 1 st quarter 2014 2022 was retrospectively...

The profiles of cardiovascular toxicity associated with angiogenesis inhibitors, including intravenous monoclonal antibodies (mAbs) and oral tyrosine kinase inhibitors (TKIs), targeting vascular endothelial growth factor (VEGF) remain poorly elucidated in real-world settings. This pharmacovigilance analysis aimed to comprehensively investigate the frequency, spectrum, timing, outcomes toxicities explore differences such patterns between mAbs TKIs.Disproportionality was performed by...

Preeclampsia (PE) is associated with hypercoagulability, endothelial dysfunction and inflammation, which generate microparticles (MPs). Therefore, MPs may be important for PE.We established a verified MP measurement procedure to detect in nonpregnant women (n = 25), healthy pregnant 29) PE 73) compared their levels.Microparticles prepared from platelets (PMPs), cells (EMPs) leucocytes (LMPs) were confirmed by transmission electron microscopy analysed our flow cytofluorimetric approach,...

In recent years, research regarding mean platelet volume (MPV) has been expanded to numerous diseases. The aim of the present study was assess whether MPV could reflect disease activity adult patients with systemic lupus erythematosus (SLE).A total 128 SLE were enrolled in and allocated into two subgroups (99 active phase 29 inactive phase) according index (SLEDAI). Demographic data, MPV, complement 3 (C3), 4 (C4) recorded. Independent sample t-test used for comparison quantitative variables...

Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome is a serious complication of pregnancy. Postpartum hemorrhage indicates poor prognosis pregnant women with HELLP syndrome. The aim our study to investigate the predictive value coagulation markers for postpartum In retrospective cohort study, 106 patients who were diagnosed as in Peking University Third Hospital from August 2010 January 2017 analyzed. demographic characters maternal fetus, days hospital stay,...

Background Immune checkpoint inhibitors (ICIs), the treatment of multiple cancer types, can be associated with respiratory system adverse events (AEs). The aim this study is to quantify association AEs and ICIs characterize profiles ICI-related complications from Food Drug Administration Adverse Event Reporting System (FAERS) data. Methods disproportionality AE-related based on FAERS data January 2014 September 2021 was analyzed using reporting odds ratio (ROR) information component (IC) as...

The hypercoagulability of blood is related to the development and metastasis cancer. High levels D-dimer have been reported be associated with poor prognoses Here, we investigated performance biomarkers-TAT, PIC, TM, tPAI·C by new method-for monitoring cancer patients metastasis.A total 197 were enrolled. TAT, detected chemiluminescence immunoassay.Results showed that TAT PIC higher in group than those nonmetastasis (P < .01). In group, there 16 elevated D-dimer. But, these all at normal...

Background To establish and validate an laboratory information system (LIS)‐based auto‐verification (AV) by using large amounts of biochemical test results in cancer patients. Methods An algorithm the AV process was designed for pre‐analysis, analysis, post‐analysis. The limit range check adjusted three times, while delta criteria were first replaced same patients’ historical extremum results. rules 51 items tested data 121 123 samples (6 177 273 tests) 2016 that manually reviewed through...

Abstract Objective The aim of this study is to evaluate the prognostic value modified Glasgow score (mGPS) in advanced esophageal squamous cell carcinoma (SCC) patients. Methods enrolled 311 patients with SCC from January 2012 December 2018. Univariate and multivariate analyses were calculated by Cox proportional hazards regression model Kaplan–Meier method was used ability mGPS for survival rates. Propensity score‐matched (PSM) analysis carried out balance imbalanced variables. Results...

To explore the standardized performance of a FISH probe before clinical detection.

Venous thromboembolism (VTE) is one of the most serious complications cancer, which has become second leading cause death in cancer patients. Therefore, early prediction and prevention VTE plays an important role improving prognosis patients.In recent years, with continuous development experimental techniques clinical medicine, laboratory should pay attention to assist tumor thrombosis risk, understand predictive model new progress indicators their application potential. Key words:...

Objective: To study the association between AKAP12 promoter methylation and recurrence of hepatocellular carcinoma. Methods: A total 142 primary liver cancer patients underwent surgery in department Hepatobiliary Peking University Cancer Hospital from 2003 to 2009 were selected as subjects survey; with inclusion criteria carcinoma, no cells observed surgical margin(SM) samples. All had neither lymph nor distant metastasis at time surgery, receiving complete follow-up data for least 3 years....

Current predictive tools assess catheter-related thrombosis (CRT) in patients with lung cancer a static manner at single time point of catheterization. The subsequent hazard changes over are unknown. conditional thrombosis-free probability (CCFP) can provide dynamic information on continual CRT-free expectations. This study aimed to the CCFP and rates based risk categories various venous access devices (VADs).This retrospective reviewed 939 peripherally inserted central catheters (PICCs) or...

Clopidogrel is a prodrug, the minority of which converted to an active metabolite by hepatic cytochrome P450 (CYP2C19), however, most it metabolized inactive substance carboxylesterase1 (CES1). Meanwhile angiotensin-converting enzyme inhibitors (ACEIs) are mostly CES1. We aimed assess impact ACEIs on platelet inhibition clopidogrel.We genotyped variants CES1, CYP2C19*2 and *3 in 502 patients with acute coronary syndrome (ACS) receiving clopidogrel therapy, analyzed effects responsiveness...

Objective: To investigate the clinical value of combined detection serum miR-378 and miR-21 in gastric cancer (GC). Methods: Eighty-seven patients with GC 78 colorectal cancer(CRC) from National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences were selected, 83 individuals undergoing healthy physical examination selected as controls. The levels detected by quantitative real-time PCR (RT-qPCR) (result data transformed log2 for analysis). Results: Relative expression -1.24,...

Objective The aim of this study is to investigate the variation tendency coagulation and fibrinolysis biomarkers in cancer patients explore effect these for diagnosis thrombosis patients. Methods 171 admitted hospital from September 2017 July 2019 were enrolled study, including 40 undergoing surgery, 108 without surgery control group 23 with thrombus. New biomarkers, TM (Thrombomodulin), TAT (Thrombin -antithrombin complex), PIC (Plasmin alpha 2-plasmin inhibitor complex) t-PAI·C...

Antiplatelet medicines have been one of the cornerstones in treatment patients with acute coronary syndrome (ACS). However, adverse cardiovascular events still occur some on standard antiplatelet therapy. Therefore, a reliable laboratory test to monitor residual platelet activity (RPA) is urgent. We aim modify impedance whole blood aggregation (WBA) assay associated release RPA, despite therapy and assess their relationship clinical ischemic events. In this study, RPA was tested 133 ACS...

A reliable laboratory test to monitor onclopidogrel platelet reactivity (PR) is very necessary. In addition, genetic factors also play an important part in PR. This study aimed modify the original impedance whole blood aggregation assay associated with release PR and assess their relationship genotype.We adjusted concentration of calcium vitro reaction system assay. Meanwhile, chronolume, which quantified adenosine triphosphate (ATP) released from dense granules, added this reflect function....

Objective: To analyze the clinicopathological characteristics of 11 cases chronic lymphocytic leukemia (CLL) with t (14;19) (q32;q13) . Methods: The case data patients CLL in chromosome karyotype analysis results Blood Diseases Hospital, Chinese Academy Medical Sciences from January 1, 2018, to July 30, 2022, were retrospectively analyzed. Results: In all patients, involved IGH::BCL3 gene rearrangement, and most them accompanied by +12 or complex karyotype. An immunophenotypic score 4-5 was...