A5100347386- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Laser-induced spectroscopy and plasma
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Analytical chemistry methods development
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Cultural Heritage Materials Analysis
- Mercury impact and mitigation studies
- Immune cells in cancer
- Herpesvirus Infections and Treatments
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Cancer Cells and Metastasis
- Systemic Sclerosis and Related Diseases
- CAR-T cell therapy research
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Pleural and Pulmonary Diseases
- vaccines and immunoinformatics approaches
Zhengzhou University
2022-2025
Affiliated Hospital of Hangzhou Normal University
2021-2024
Huazhong University of Science and Technology
2019-2024
Union Hospital
2020-2024
University College London
2023-2024
Harbin Veterinary Research Institute
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Xinjiang Agricultural University
2024
Ocean University of China
2022-2024
Nanjing Medical University
2022-2024
Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence abundant immunosuppressive cells. Tumor-associated macrophages (TAMs), as dominant population, impede antitumor response; however, underlying mechanisms have not been fully elucidated yet.Single-cell RNA sequencing analysis was performed portray macrophage landscape and revealed mechanism...
Drug resistance and tumor recurrence remain clinical challenges in the treatment of urothelial carcinoma (UC). However, underlying mechanism is not fully understood. Here, we performed single-cell RNA sequencing identified a subset cells with epithelial-mesenchymal transition (EMT) features (EMT-UC), which significantly correlated chemotherapy cancer recurrence. To validate significance EMT-UC, constructed EMT-UC like by introducing overexpression two markers, Zinc Finger E-Box Binding...
Malignant pleural effusion (MPE) is a functional 'cold' tumor microenvironment in which the antitumor activity of CD8+ T cells and natural killer (NKT)-like suppressed function regulatory (Treg) enhanced. Using flow cytometry immunofluorescence staining, we detected distinct subset NKT-like expressing FOXP3 MPE. Through single-cell RNA sequencing (scRNA-seq) analysis, found that glycolysis pathway pyruvate metabolism were highly activated FOXP3+ cells. Similar to Treg cells, expressed...
There are two main challenges in the diagnosis of blood cancer. The first is to diagnose cancer from healthy control, and second identify types chemometrics method combined with laser-induced breakdown spectroscopy (LIBS) can be used for detection. However, methods were easily influenced by spectral feature redundancy noise, resulting low accuracy rate because their simple structure. We proposed an approach using LIBS ensemble learning based on random subspace (RSM). serum samples dripped...
Objectives: Circular RNAs (circRNAs) have been found to significant impacts on non-small cell lung cancer (NSCLC) progression through various mechanisms. However, the mechanism of circRNAs modulating tumor immune evasion in NSCLC has yet be well-revealed. Materials and Methods: Through analyzing expression profiles tissues, RNA FISH, pull-down assay, mass spectrometry analysis, RIP, circCRIM1 was identified, its interaction with IGF2BP1 confirmed. The effects were explored via co-culture...
Neuromyelitis optica spectrum disorders (NMOSD) are primarily autoimmune diseases mediated by B cells and AQP4-IgG antibodies, typically affecting the optic nerves spinal cord, characterised high relapse rates significant disability. We present two cases of NMOSD patients who also had systemic lupus erythematosus (SLE), with one case additionally complicated myasthenia gravis (MG). Both initially received first-line treatment corticosteroids; however, no clinical improvement was observed; As...
Abstract Acute haemorrhagic conjunctivitis (AHC) outbreaks are reported frequently in China. However, the transmissibility of AHC remains unclear. This study aimed to calculate disease with and without interventions. An outbreak dataset from January 2007 December 2016 different schools was built Hunan Province. A Susceptible-Infectious-Recovered (SIR) model adopted effective reproduction number ( R eff ) AHC. divided into two parts unc con where represent uncontrolled controlled ,...
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy an important treatment for NPC. However, molecular mechanism resistance to platinum drug remains unknown. Endoplasmic reticulum resident protein 44(ERp44), unfolded response (UPR)-induced endoplasmic reticulum(ER) protein, induced during ER stress. This research explored ERp44 strengthening cisplatin NPC.Western blot immunohistochemistry were used investigate expression...
Accumulating evidence indicates that circular RNAs (circRNAs) play important roles in various cancers. Hsa_circ_0008832 (circFBXO7) is a circRNA generated from the second exon of human F-box only protein 7 (FBXO7). Mouse circFbxo7 mouse (Fbxo7). The role circFBXO7 and non-small cell lung cancer (NSCLC) has not been reported. expression was measured by quantitative real-time PCR. Survival analysis performed to explore association between prognosis patients with NSCLC. Lung lines were...
Background: Regulatory T cells (Tregs) may represent a major cellular mechanism in immune suppression by dampening the anti-tumor response malignant pleural effusion (MPE). Tumor necrosis factor receptor type II (TNFR2) has emerged as novel identification for maximally suppressive subset of Tregs tumor environment. At present, significance TNFR2 expression on MPE remains unclear. Methods: The distribution TNFR2+cells and effector (Teffs) MPE, peripheral blood (PB), tuberculosis (TPE) were...
The tumor microenvironment contributes to the survival and development of cells is therefore a key target for cancer therapy. has unique physical chemical properties associated with inflammation immunity. To examine correlation between microenvironment-associated factors efficacy prognosis neoadjuvant therapy rectal cancer, compare differences two treatments [neoadjuvant chemotherapy (NAC) vs. chemoradiotherapy (NACR)], an immunohistochemical method was used measure expression levels CD4+...
Natural killer (NK) cells have shown good application prospects in adoptive cellular immunotherapy against cancer. However, due to its insufficient infiltration and low activity, the therapeutic effect of infused NK has been limited solid tumors, such as colorectal It proved that tumor-produced chemokines regulate migration expressing corresponding chemokine receptors, cytokines could enhance antitumor activity cells. In this study, we innovatively upregulated expression receptor CXC 2...