A5069278320- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Sirtuins and Resveratrol in Medicine
- Urinary Tract Infections Management
- Cancer-related molecular mechanisms research
- Nuts composition and effects
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Flavonoids in Medical Research
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Dialysis and Renal Disease Management
- Ureteral procedures and complications
- Biomarkers in Disease Mechanisms
Guangxi Medical University
2022-2025
First Affiliated Hospital of GuangXi Medical University
2022-2025
Drug resistance and tumor recurrence remain clinical challenges in the treatment of urothelial carcinoma (UC). However, underlying mechanism is not fully understood. Here, we performed single-cell RNA sequencing identified a subset cells with epithelial-mesenchymal transition (EMT) features (EMT-UC), which significantly correlated chemotherapy cancer recurrence. To validate significance EMT-UC, constructed EMT-UC like by introducing overexpression two markers, Zinc Finger E-Box Binding...
The mitochondrial potassium channel Kv1.3 is a critical therapeutic target, as its blockade induces cancer cell apoptosis, highlighting potential. PAP-1, potent and selective membrane-permeant inhibitor, faces solubility challenges affecting bioavailability antitumor efficacy. To circumvent these challenges, we developed tumor-targeting drug delivery system by encapsulating PAP-1 within pH-responsive mPEG-PAE polymeric micelles. These self-assembled micelles exhibited high entrapment...
To compare the dusting efficiency and safety with basketing for treating renal stones ≤ 2 cm during flexible ureteroscopy (fURS).This study included 218 patients treated fURS. Among them, 106 underwent dusting, 112 fragmentation basket extraction. All were followed up 3 months postoperatively. The operating time, lasing stone-free rate (SFR) complication compared.The mean stone size in group was 1.3 cm, whereas 1.4 group. operative time significantly lower than (43.1±11.7 minutes VS...
Nephrolithiasis is one of the most prevalent diseases urinary system. Approximately 80% human kidney stones are composed calcium oxalate (CaOx), and hypercalciuria common metabolic disorders. Emerging evidence indicates that autophagy inflammatory responses related to formation CaOx nephrolithiasis. However, roles inflammation in patients with remain unclear. Ethyl pyruvate (EP) displays protective effects experimental models many illnesses. In this study, we investigated EP vitro through...
Bladder urothelial carcinoma (BLCA) is a common malignant tumor of the human urinary system, and large proportion BLCA patients have poor prognosis. Therefore, there an urgent need to find more efficient sensitive biomarkers for prognosis in clinical practice. RNA sequencing (RNA-seq) data information were obtained from The Cancer Genome Atlas, 584 energy metabolism-related genes (EMRGs) Reactome pathway database. Cox regression analysis least absolute shrinkage selection operator applied...
More muscle-invasive bladder cancer (MIBC) patients are now eligible for bladder-preserving therapy (BPT), underscoring the need precision medicine. This study aimed to identify prognostic predictors and construct a predictive model among MIBC who undergo BPT.
This study aims to reveal immunophenotypes associated with immunotherapy response in bladder cancer, identify the signature genes of immune subtypes, and provide new molecular targets for improving response.Bladder cancer were characterized bulk RNA sequencing dataset GSE32894 Imvigor210, gene expression signatures established immunophenotypes. Expression validated single-cell GSE145140 human proteins data source. Investigation Immunotherapy Response was performed IMvigor210 dataset....
Abstract Objectives: The aim of this study was to investigate factors predicting spontaneous stone passage after flexible ureteroscopic lithotripsy ( fURS) for renal stones. Materials and Methods: This included 239 patients with stones who underwent fURS using the dusting technique. final outcome evaluated 3 months postoperatively residual fragment status (RFs) defined as any fragments greater than 2 mm. Univariate multivariate analyses possible predictive associated clearance were...