A5108055248- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Single-cell and spatial transcriptomics
- Renal cell carcinoma treatment
- Respiratory Support and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Cancer Cells and Metastasis
- Eosinophilic Esophagitis
- Cancer Genomics and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bladder and Urothelial Cancer Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
Guangxi Medical University
2022-2024
Breast cancer (BC) is a highly heterogeneous disease, and although immunotherapy has recently increased patient survival in number of solid hematologic malignancies, most BC subtypes respond poorly to immune checkpoint blockade therapy (ICB). B cells, particularly those that congregate tertiary lymphoid structures (TLS), play significant role antitumour immunity. However, B-cell heterogeneity at single-cell resolution its clinical significance with TLS need be explored further.Primary tumour...
Bladder urothelial carcinoma (BLCA) is a common malignant tumor of the human urinary system, and large proportion BLCA patients have poor prognosis. Therefore, there an urgent need to find more efficient sensitive biomarkers for prognosis in clinical practice. RNA sequencing (RNA-seq) data information were obtained from The Cancer Genome Atlas, 584 energy metabolism-related genes (EMRGs) Reactome pathway database. Cox regression analysis least absolute shrinkage selection operator applied...
Investigating the interaction between Mast cells (MCs) and Mononuclear Phagocytes (MPs) in tumor microenvironment (TME) of blader cancer (BCa) to uncover potential immunotherapeutic targets.
Resulting from severe inflammation and cell destruction, COVID-19 patients could develop pulmonary fibrosis (PF), which remains in the convalescent stage. Nevertheless, how immune response participates pathogenesis of PF progression is not well defined. To investigate that question, 12 with were included study. Peripheral mononuclear (PBMC) samples collected shortly after their admission proceeded for single-cell RNA sequencing (scRNA-seq). After 14 days discharge, revisited chest CT scan....
Background IgA nephropathy (IgAN) is a leading cause of renal failure, but its pathogenesis remains unclear, complicating diagnosis and treatment. The invasive nature biopsy highlights the need for non-invasive diagnostic biomarkers. Bulk RNA sequencing (RNA-seq) urine offers promising approach identifying molecular changes relevant to IgAN. Methods We performed bulk RNA-seq on 53 samples from 11 untreated IgAN patients healthy controls, integrating these data with public RNA-seq,...
Background: Diabetic kidney disease (DKD) is a chronic renal which could eventually develop into failure. Though albuminuria and estimated glomerular filtration rate (eGFR) are helpful for the diagnosis of DKD, lack specific biomarkers reduces efficiency therapeutic interventions. Methods: Based on bulk-seq 56 urine samples collected at different time points (including 11 acquired from DKD patients healthy controls), in corporation scRNA-seq data snRNA-seq punctures (retrieved NCBI GEO...