Jianxin Chen

ORCID: 0000-0002-9930-0382
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About
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Research Areas
  • Cancer-related molecular mechanisms research
  • Plant Pathogens and Fungal Diseases
  • GABA and Rice Research
  • Biological and pharmacological studies of plants
  • Gene expression and cancer classification
  • Histone Deacetylase Inhibitors Research
  • Microbial Metabolic Engineering and Bioproduction
  • Biocrusts and Microbial Ecology
  • Eosinophilic Esophagitis
  • Plant responses to water stress
  • Cancer Mechanisms and Therapy
  • Photosynthetic Processes and Mechanisms
  • Brain Metastases and Treatment
  • Cancer Research and Treatments
  • Nuclear Receptors and Signaling
  • Enzyme Structure and Function
  • MicroRNA in disease regulation
  • Ginseng Biological Effects and Applications
  • Hedgehog Signaling Pathway Studies
  • Mass Spectrometry Techniques and Applications
  • Advanced Chemical Sensor Technologies
  • Algal biology and biofuel production
  • Gut microbiota and health
  • Process Optimization and Integration
  • IL-33, ST2, and ILC Pathways

Southwest Forestry University
2025

First Affiliated Hospital of GuangXi Medical University
2019-2024

Guangxi Medical University
2019-2024

Tumor Hospital of Guangxi Medical University
2024

Wenzhou Medical University
2023

Beijing University of Chinese Medicine
2022

Shandong University of Traditional Chinese Medicine
2020

Putian University
2019

University of Pennsylvania
2018

Optica
2018

Sepsis-induced liver injury (SILI) is an important cause of septicemia deaths. BaWeiBaiDuSan (BWBDS) was extracted from a formula Panax ginseng C. A. Meyer, Lilium brownie F. E. Brown ex Miellez var. viridulum Baker, Polygonatum sibiricum Delar. Redoute, Lonicera japonica Thunb., Hippophae rhamnoides Linn., Amygdalus Communis Vas, Platycodon grandiflorus (Jacq.) DC., and Cortex Phelloderdri. Herein, we investigated whether the BWBDS treatment could reverse SILI by mechanism modulating gut...

10.1016/j.apsb.2022.10.016 article EN cc-by-nc-nd Acta Pharmaceutica Sinica B 2022-10-22

Abstract Accumulating studies have recognized microRNAs (miRs) and long noncoding RNAs (lncRNAs) as important molecules involved in the mediation of various biological processes, including innate immunity. In this study, we investigated a novel RNA regulatory circuitry immunity during sepsis. A cecal ligation puncture‐induced sepsis mouse model was established to determine expression mast cell membrane protein 1 (MCEMP1). The crosstalk among lncRNA nuclear enriched abundant transcript...

10.1002/iub.2033 article EN IUBMB Life 2019-03-18

Tuber rot caused by Fusarium cugenangense is a serious problem in the cultivation and post-harvest preservation of Gastrodia. It essential to explore effective biocontrol methods control this disease. In work, we investigated efficiency defense responses an endophytic Streptomyces globisporus strain WB03 isolated from coralloid roots Cycas panzhihuaensis against Gastrodia tuber S. can secrete extracellular hydrolases that produce active compounds. Treatment with damaged cell membranes F....

10.1094/pdis-09-24-1994-re article EN Plant Disease 2025-03-27

Antiglioma effects of cytarabine on leptomeningeal metastasis high-grade glioma by targeting the PI3K/Akt/mTOR pathway Kai-Hong Zhao,1 Can Zhang,2 Yue Bai,1 Yan Li,1 Xun Kang,1 Jian-Xin Chen,1 Kun Yao,3 Tao Jiang,4 Xiao-Song Zhong,2 Wen-Bin Li1 1Department Glioma, 2Clinical Center Gene And Cell Engineering, Beijing Shijitan Hospital, 3Department Neurosurgery, Tiantan 4Department Pathology, Sanbo Brain Capital Medical University, Beijing, People’s Republic China Abstract: Leptomeningeal...

10.2147/dddt.s135711 article EN cc-by-nc Drug Design Development and Therapy 2017-06-01

Investigating the interaction between Mast cells (MCs) and Mononuclear Phagocytes (MPs) in tumor microenvironment (TME) of blader cancer (BCa) to uncover potential immunotherapeutic targets.

10.7150/jca.99554 article EN cc-by-nc Journal of Cancer 2024-01-01

We employ site-specific, linear and nonlinear infrared spectroscopic techniques as well fluorescence spectroscopy molecular dynamics simulations to investigate the binding interactions of urea three its derivatives, methylurea, 1,3-dimethylurea, tetramethylurea, with protein aromatic polar side chains. find that (1) methylation leads preferential between cosolvent molecules chains an affinity increases number methyl groups; (2) tetramethylurea cause significant dehydration effect is most...

10.1021/acs.jpclett.8b00960 article EN The Journal of Physical Chemistry Letters 2018-05-16

Cancers harboring serine threonine kinase (STK11) alteration or SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1 (SMARCB1) mutation are conventionally considered as treatment-refractory to immune checkpoint inhibitors chemotherapy, respectively. However in the present report, we demonstrated a case dedifferentiated non-small cell lung cancer, characterized by STK11 loss (due promoter loss) co-mutated with SMARCB1 deficiency mutation, has...

10.3389/fonc.2023.1088534 article EN cc-by Frontiers in Oncology 2023-01-27
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