A5030349874- Glioma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Ginseng Biological Effects and Applications
- Eicosanoids and Hypertension Pharmacology
- Pharmacogenetics and Drug Metabolism
- Advancements in Transdermal Drug Delivery
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Computational Drug Discovery Methods
- DNA Repair Mechanisms
- Medicinal Plants and Bioactive Compounds
- Drug-Induced Hepatotoxicity and Protection
- Aldose Reductase and Taurine
- Berberine and alkaloids research
- Skin Protection and Aging
University of Science and Technology of China
2020-2023
Macau University of Science and Technology
2020-2023
Quality Research
2023
Chinese Academy of Sciences
2021-2022
Hefei Institutes of Physical Science
2021-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2020
Kunming Medical University
2020
First Affiliated Hospital of Kunming Medical University
2020
Anhui Provincial Hospital
2020
Daping Hospital
2009-2011
Sepsis-induced liver injury (SILI) is an important cause of septicemia deaths. BaWeiBaiDuSan (BWBDS) was extracted from a formula Panax ginseng C. A. Meyer, Lilium brownie F. E. Brown ex Miellez var. viridulum Baker, Polygonatum sibiricum Delar. Redoute, Lonicera japonica Thunb., Hippophae rhamnoides Linn., Amygdalus Communis Vas, Platycodon grandiflorus (Jacq.) DC., and Cortex Phelloderdri. Herein, we investigated whether the BWBDS treatment could reverse SILI by mechanism modulating gut...
Ginseng polysaccharide (GP) is one of the most abundant components in Panax ginseng. However, absorption pathways and mechanisms GPs have not been investigated systematically due to challenges their detection. The fluorescein isothiocyanate derivative (FITC) was employed label GP ginseng acidic (GAP) obtain target samples. HPLC-MS/MS assay used determine pharmacokinetics GAP rats. Caco-2 cell model investigate uptake transport Our results demonstrated that more than rats after gavage...
Abstract Background A large number of preclinical studies have shown that local anesthetics a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few the role in cancer stem cells. This study aimed to determine possible glioblastoma (GSC) self-renewal underlying molecular mechanisms. Methods The effects GSCs were investigated through vitro vivo assays (i.e., Cell Counting Kit 8, spheroidal formation assay, double...
Glioblastoma multiforme and other solid malignancies are heterogeneous, containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known as POU5F1, is a key transcription factor in the self-renewal, proliferation, differentiation cells. Although it has been detected advanced gliomas, biological function transcriptional machinery maintained by stemness Oct4 protein-mediated glioma (GSC), not fully determined.The expression variants was evaluated brain cancer cell...
Objectives: Iron deficiency is associated with elevated platelet counts (PLT), through mechanisms that are poorly understood. Through in vitro study, we demonstrated iron influences erythropoiesis and thrombopoiesis by regulating hematopoietic stem progenitor cells (HSPCs) commitment towards the two lineages. Specifically, a high concentration of drives HSPCs into erythroid lineage, whereas low promotes megakaryocytic lineage. In this aim to 1) further investigate effect on vivo using rats...
Benzoxaboroles are a novel class of drug-like compounds that have been rich sources inhibitors for various enzymes and new drugs. While examining benzoxaborole activity in phenotypic screens, our attention was attracted by the (aminomethylphenoxy)benzoxaborole family, which potently inhibited Toll-like receptor–stimulated cytokine secretion from leukocytes. After considering their structure-activity relationships central role kinases leukocyte biology, we performed kinome-wide screen to...
Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression GBM. The role of protein GBM, however, has not been systematically reported. This study aimed to investigate the effect on GBM cell survival cycle. In this study, most palmitoyltransferases were upregulated its lines, participated signaling pathways controlling Inhibition with substrate-analog...
Glioblastoma (GBM) is the most common and deadly of primary intracranial tumors comprised subsets that show plasticity marked heterogeneity, contributing to lack success in genomic profiling guide development precision medicine for these tumors. In this study, a mutation isocitrate dehydrogenase 1 was found suppress transforming growth factor-beta signaling pathway E2F4 interacted with Smad3 inhibit expression mesenchymal markers. However, palmitoylation mediated by palmitoyltransferase...
Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered key hub for promoting malignant phenotypes in GBM. However, the functional relationships between GSK3β and GSCs GBM unclear. Here, we found that was noted as substrate ZDHHC4-mediated palmitoylation at Cys14 residue, which enhanced temozolomide (TMZ) resistance GSC self-renewal. Clinically, expression level ZDHHC4 upregulated GBM, significantly...
Abstract Glioblastoma (GBM) is associated with an increasing mortality and morbidity considered as aggressive brain tumor. Recently, extensive studies have been carried out to examine the molecular biology of GBM, progression GBM has suggested be correlated tumor immunophenotype in a variety studies. Samples current study were extracted from ImmPort TCGA databases identify immune-related genes affecting prognosis. A total 92 displaying significant correlation prognosis mined, shrinkage...
Background: The reduced vascular reactivity after severe trauma or shock played an important role in the development and outcome of shock. Our previous study showed that protein kinase C (PKC) took part regulation hemorrhagic objective this was to investigate protective effects activation PKC on its related mechanism. Methods: Sprague dawley rats were subjected (40 mm Hg for 2 hours). Effects agonist, phorbol-12-myristate-13-acetate (PMA), inhibitor, staurosporine, hemodynamic parameters...
Abstract Background Epidermal biophysical properties can be affected by many factors, including body site, age, gender, ethnicity, disease, temperature, humidity, and ultraviolet (UV) radiation. Information about variation of epidermal with seasons is still limited. In the present study, we determined seasonal women in Kunming, China. Materials Methods A total 72 women, aged 22.96 ± 2.11 years, were enrolled this study. Transepidermal water loss rates (TEWL), stratum corneum (SC) hydration,...
Abstract Background Sensitive skin manifests itself as a syndrome defined by the occurrence of unpleasant sensations such stinging, burning, and pruritus. Though not life‐threatening, it can negatively impact quality people's lives because symptoms clinical signs. Although some care products alleviate sensitive skin, product that improve multiple abnormalities are largely unavailable. Aims To assess efficacy newly developed herbal cream in reducing erythema. Methods A randomized double‐blind...