A5082376550- Glioma Diagnosis and Treatment
- FOXO transcription factor regulation
- Advanced Measurement and Metrology Techniques
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Adaptive optics and wavefront sensing
- Cancer-related Molecular Pathways
- Optical Coatings and Gratings
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Surface Roughness and Optical Measurements
- Optical Systems and Laser Technology
- MRI in cancer diagnosis
- TGF-β signaling in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Regulation of Appetite and Obesity
- Mechanisms of cancer metastasis
- Sodium Intake and Health
- Advanced Surface Polishing Techniques
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
- Erythropoietin and Anemia Treatment
- Wnt/β-catenin signaling in development and cancer
- Pluripotent Stem Cells Research
- Apelin-related biomedical research
Hefei Institutes of Physical Science
2021-2022
Chinese Academy of Sciences
2019-2022
University of Science and Technology of China
2021-2022
Institute of Optics and Electronics, Chinese Academy of Sciences
2019-2021
Glioblastoma multiforme and other solid malignancies are heterogeneous, containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known as POU5F1, is a key transcription factor in the self-renewal, proliferation, differentiation cells. Although it has been detected advanced gliomas, biological function transcriptional machinery maintained by stemness Oct4 protein-mediated glioma (GSC), not fully determined.The expression variants was evaluated brain cancer cell...
Glioblastoma (GBM) is the most common and deadly of primary intracranial tumors comprised subsets that show plasticity marked heterogeneity, contributing to lack success in genomic profiling guide development precision medicine for these tumors. In this study, a mutation isocitrate dehydrogenase 1 was found suppress transforming growth factor-beta signaling pathway E2F4 interacted with Smad3 inhibit expression mesenchymal markers. However, palmitoylation mediated by palmitoyltransferase...
Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered key hub for promoting malignant phenotypes in GBM. However, the functional relationships between GSK3β and GSCs GBM unclear. Here, we found that was noted as substrate ZDHHC4-mediated palmitoylation at Cys14 residue, which enhanced temozolomide (TMZ) resistance GSC self-renewal. Clinically, expression level ZDHHC4 upregulated GBM, significantly...
Intramuscular injections of long-acting synthetic ACTH (45 U twice daily for 5 days) caused a large increase in the intake 0.5 M NaCl sheep. Mean Na sheep on last 3 days treatment approximated 50% their total extracellular fluid Na. The mineral appetite was specific NaCl. Intakes KCl or 0.25 CaCl2 were not significantly altered. enhanced induced by appeared to precede any urinary excretion. ineffective adrenalectomized However, an infusion into combination adrenal steroid hormones (including...
A theoretically designed rotating shadow mask is proposed to optimize the uniformity of a simple rotation system, which makes full use width coating chamber. This method can fabricate large-aperture optical component, diameter more than half machine. The applied correct film thickness near center point plane substrate. factors influencing effect are simulated and discussed. Then shape designed, within corresponding radius well corrected. After determining mask, an additional fixed calculated...