A5044121110- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Pain Management and Opioid Use
- Neurogenesis and neuroplasticity mechanisms
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Apelin-related biomedical research
- Cytomegalovirus and herpesvirus research
- Cancer-related Molecular Pathways
- Calcium signaling and nucleotide metabolism
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Paraoxonase enzyme and polymorphisms
- Sirtuins and Resveratrol in Medicine
- RNA Research and Splicing
- interferon and immune responses
- Lung Cancer Treatments and Mutations
Hefei Institutes of Physical Science
2022-2024
Chinese Academy of Sciences
2022-2024
University of Science and Technology of China
2022-2024
Hefei Infectious Disease Hospital
2023
Weatherford College
2022
Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered key hub for promoting malignant phenotypes in GBM. However, the functional relationships between GSK3β and GSCs GBM unclear. Here, we found that was noted as substrate ZDHHC4-mediated palmitoylation at Cys14 residue, which enhanced temozolomide (TMZ) resistance GSC self-renewal. Clinically, expression level ZDHHC4 upregulated GBM, significantly...
Neuropathic cancer pain (NCP) is an important symptom in patients with cancer. However, significant analgesic tolerance and other side effects critically hamper the administration of morphine. Protein palmitoylation mediated by DHHC family may be involved glial activation inflammatory responses underlying organ failure. In this study, we investigated key role protein sought to target suppress morphine tolerance. We found that long-term use led accumulation metabolite, morphine-3-glucuronide,
Background Cancer pain has a significant impact on patient’s quality of life. Astrocytes play an important role in cancer signaling. The direct targeting astrocytes can effectively suppress pain, however, they cause many side effects. Therefore, there is urgent need to identify the specific signaling pathways or proteins involved within as targets for treating pain. Methods A neuropathic (NCP) model was established by inoculating mouse S-180 sarcoma cells around right sciatic nerve C57BL/6...
Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and leading cause death worldwide. Its progression characterized by genomic instability. In turn, level instability affects prognosis immune status patients with LUAD. However, impact molecular features associated on tumor microenvironment (TME) has not been well characterized. addition, effect genes related to in LUAD individualized treatment unknown.The RNA-Sequencing, somatic mutation, clinical...
Pyroptosis is a programmed cell death mediated by the gasdermin superfamily, accompanied inflammatory and immune responses. Exogenously activated pyroptosis still not well characterized in tumor microenvironment. Furthermore, whether pyroptosis-related genes (PRGs) lower-grade glioma (LGG) may be used as biomarker remains unknown.The RNA-Sequencing clinical data of LGG patients were downloaded from publicly available databases. Bioinformatics approaches to analyze relationship between PRGs...
Abstract Copper is essential in living organisms and crucial to various physiological processes. Normal conditions are a state of copper homeostasis ensure normal biochemical metabolic Dysregulation has been associated with multiple diseases, especially cancer. Cuproptosis copper-dependent cell death mediated by excess or dysregulation. Elesclomol common inducer cuproptosis, carrying into the producing copper. modulates tumor proliferation-related signaling pathways closely remodeling...