A5051847291- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- melanin and skin pigmentation
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Occupational exposure and asthma
- Food Allergy and Anaphylaxis Research
- Dermatologic Treatments and Research
- Asthma and respiratory diseases
- Cutaneous Melanoma Detection and Management
- Urticaria and Related Conditions
- Bee Products Chemical Analysis
- Neonatal skin health care
- Ocular Surface and Contact Lens
- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Medical Practices and Rehabilitation
- Acne and Rosacea Treatments and Effects
- Peroxisome Proliferator-Activated Receptors
- Nonmelanoma Skin Cancer Studies
- Wound Healing and Treatments
- Animal testing and alternatives
San Francisco VA Medical Center
2016-2025
University of California, San Francisco
2016-2025
Helios Hospital Siegburg
2025
Southern Medical University
2018-2024
First Affiliated Hospital of Hebei Medical University
2021-2024
Lucian Blaga University of Sibiu
2024
Hebei Medical University
2021-2024
Institute for Prevention and Occupational Medicine
2014-2023
San Francisco VA Health Care System
2020-2023
Northern California Institute for Research and Education
2010-2022
We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold atopic dermatitis (AD) patients. markedly enhanced on primary afferent nerve fibers skin biopsies AD Intracutaneous injection agonists provoked and prolonged itch when applied intralesionally. Moreover, upon mast cell degranulation abolished by local antihistamines controls but prevailed Thus, we identified...
<h3>Abstract</h3> <b>Objective</b> To determine the effects of age related, structured educational programmes on management moderate to severe atopic dermatitis in childhood and adolescence. <b>Design</b> Multicentre, randomised controlled trial. <b>Setting</b> Seven hospitals Germany. <b>Participants</b> Parents children with aged 3 months 7 years (n = 274) 8-12 102), adolescents 13-18 70), controls 244, n 83, 50, respectively). <b>Interventions</b> Group sessions standardised intervention...
Hand eczema is a common inflammatory skin disorder. Health care providers need continuously updated information about the management of hand to ensure best treatment for their patients.To update European Society Contact Dermatitis guideline on diagnosis, prevention, and eczema.The Guideline Development Group (GDG) was established behalf ESCD. A call interest launched via ESCD website members' mailing list. Appraisal evidence therapeutic preventive interventions applied structured method...
Hydrolysis of glucosylceramide by beta-glucocerebrosidase results in ceramide, a critical component the intercellular lamellae that mediate epidermal permeability barrier. A subset type 2 Gaucher patients displays ichthyosiform skin abnormalities, as do transgenic mice homozygous for null allele. To investigate relationship between glucocerebrosidase deficiency and barrier function, we compared stratum corneum (SC) ultrastructure, lipid content, function to carrier normal mice, hairless...
This report reviews the clinical and histopathological reactions caused by sodium lauryl sulfate (SLS), non-invasive methods that can characterize these reactions. Furthermore, SLS exposure techniques factors may influence outcome of exposures are discussed. Finally, guidelines introduced for each technique in order to have a uniform approach testing man. Since different study aims warrant conditions, we proposed 2 categories, namely susceptibility provocative testing, tailored aim with...
We examined the possibility that cutaneous permeability barrier regulates epidermal DNA synthesis in two acute and chronic models of perturbation. In animals treated topically with acetone, is increased 102%, tape-stripped 127%, essential fatty acid deficient 50%, chronically topical lovastatin 64%. This linkage between disturbances function further supported by specific correlative observations: (a) these disparate models, artificial replacement a water-impermeable membrane inhibits...
<i>Background and Objectives:</i> Evidence suggests the importance of skin biophysical properties in predicting diseases developing appropriate care. The results to date studies on surface pH, stratum corneum (SC) hydration sebum content both genders at various ages have been inconclusive, which was part due small sample size. Additionally, little is known about physical Asian, especially Chinese, subjects. In present study, we assess difference SC a large Chinese population...
A mixture of sphingolipids, cholesterol, and free fatty acids forms the intercellular membrane bilayers stratum corneum which are presumed to regulate epidermal barrier function. Prior studies have shown that both cholesterol acid synthesis rapidly regulated by requirements. In contrast, importance sphingolipids in function has not been directly demonstrated. Here, we assessed sphingolipid [3H]H2O incorporation serine palmitoyl transferase (SPT) activity relation modulations Incorporation...
Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol, and free fatty acids, arranged as intercellular membrane bilayers that are presumed to mediate the epidermal permeability barrier. Prior studies have shown alterations in barrier function lead a rapid increase cholesterol acid synthesis which parallels early stages repair process. Despite abundance indirect evidence for their role barrier, importance sphingolipids has yet be demonstrated...
Topical therapy to enhance skin barrier function may be a simple, low-cost, effective strategy improve outcome of preterm infants with developmentally compromised epidermal barrier, as lipid constituents topical products act mechanical and augment synthesis lipids. Natural oils are applied topically part traditional oil massage neonates in many developing countries. We sought identify inexpensive, safe, vegetable available countries that improved function. The impact on mouse (rate...
Topical therapy to enhance skin barrier function may be a simple, low‐cost, effective strategy improve outcome of preterm infants with developmentally compromised epidermal barrier, as lipid constituents topical products act mechanical and augment synthesis lipids. Natural oils are applied topically part traditional oil massage neonates in many developing countries. We sought identify inexpensive, safe, vegetable available countries that improved function. The impact on mouse (rate...
<h3>• Background and Design.—</h3> When the epidermal permeability barrier is perturbed with acetone, transcutaneous water loss returns to normal over 24 hours in parallel reappearance of stratum corneum lipids, derived from secreted lamellar bodies accelerated lipid synthesis. Prior studies have demonstrated a separate requirement for cholesterol, fatty acid, ceramide synthesis homeostasis, but these lipids individually or together function not known. We therefore applied alone various...