A5030070250- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Lipid Membrane Structure and Behavior
- Contact Dermatitis and Allergies
- Sphingolipid Metabolism and Signaling
- Surfactants and Colloidal Systems
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Skin and Cellular Biology Research
- Bee Products Chemical Analysis
- Proteins in Food Systems
- Lipid metabolism and biosynthesis
- Advanced Drug Delivery Systems
- Acne and Rosacea Treatments and Effects
- Oral Health Pathology and Treatment
- Retinoids in leukemia and cellular processes
- Oral microbiology and periodontitis research
- Fatty Acid Research and Health
- Skin Protection and Aging
- Dental Erosion and Treatment
- Glycosylation and Glycoproteins Research
- Ocular Surface and Contact Lens
- Biochemical Analysis and Sensing Techniques
- Nail Diseases and Treatments
- Dental materials and restorations
University of Iowa
2013-2024
James Madison University
2007
Iowa City Public Library
2001
University of Wisconsin–Madison
1978-1980
Atopic dermatitis skin tends to be easily irritated and appears dry. These clinical peculiarities correspond impaired barrier function increased transepidermal water loss (TEWL) values. A few studies suggest that a reduced amount of total ceramides (especially ceramide 1) is responsible for functional abnormalities the atopic patients. The aim this study was analyze relationship between epidermal lipids impairment in patients with dermatitis. quantity ceramides, cholesterol sulphate free 47...
Seven distinguishable groups of ceramides have been isolated from pig epidermis and identified.In order increasing polarity these are: 1, N-(a-acy1oxy)acylsphingosines (7.7%); 2, N-acylsphingosines (42.4%); 3, N-acylphytosphingosines (10.2%); 4, N-(a-hydroxy)acylsphingosines (1 2.1 %); 5, 0.5%); 6a, N-[a-(a-hydroxy)acyloxy]acylsphingosines (1.7%); 6b, N-(a-hydroxy)acylphytosphingosines 5.5%).In ceramide the a-hydroxyacid moieties are predominantly CL6, whereas in a-hydroxyacids mainly...
In the epidermis of terrestrial vertebrates, lipid lamellae between horny cells are thought to form a barrier water loss. The lipids extruded from living after assembly in lamellar granules. This might be promoted by recently identified 1-(3′- O -acyl)-β-D-glucosyl- N -(ω-hydroxyacyl)sphingosines, which have 30- and 32-carbon hydroxy acids as amides linoleic acid esterified glucose. Such role for these molecules could explain effects essential fatty deficiency, granules fail assemble...
Profilaggrin is a large epidermal polyprotein that proteolytically processed during keratinocyte differentiation to release multiple filaggrin monomer units as well calcium-binding regulatory NH2-terminal S-100 protein. We show deficiency of the transmembrane serine protease Matriptase/MT-SP1 perturbs lipid matrix formation, cornified envelope morphogenesis, and stratum corneum desquamation. Surprisingly, proteomic analysis Matriptase/MT-SP1–deficient epidermis revealed selective loss both...
ABSTRACT There is growing evidence that the role of lipids in innate immunity more important than previously realized. How interact with bacteria to achieve a level protection, however, still poorly understood. To begin address mechanisms antibacterial activity, we determined MICs and minimum bactericidal concentrations (MBCs) common skin oral cavity—the sphingoid bases d -sphingosine, phytosphingosine, dihydrosphingosine fatty acids sapienic acid lauric acid—against four Gram-negative seven...