A5031368365- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Cervical Cancer and HPV Research
- melanin and skin pigmentation
- RNA regulation and disease
- Dermatology and Skin Diseases
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
- Wnt/β-catenin signaling in development and cancer
- Dermatological and Skeletal Disorders
- Biomedical Text Mining and Ontologies
- Veterinary Oncology Research
- Cancer and Skin Lesions
- Microbial infections and disease research
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Animal testing and alternatives
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Gene expression and cancer classification
- Poxvirus research and outbreaks
- Oral and Maxillofacial Pathology
- Cell Image Analysis Techniques
Jackson Laboratory
2016-2025
Vanderbilt University Medical Center
2004-2025
Meta (United States)
2023
National Institute of Environmental Health Sciences
2018
National Institutes of Health
2018
National Cancer Institute
2018
Purdue University West Lafayette
1977-2017
Software (Spain)
2017
Vanderbilt University
1996-2016
College of the Atlantic
2014
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role Notch4 gene, we generated Notch4-deficient mice by targeting. Embryos homozygous for this mutation developed normally, and mutant adults were viable fertile. However, displayed genetic interactions with a targeted related Notch1 gene. mutations both genes often more severe phenotype than embryos. Both Notch1/Notch4 double embryos...
Small-vessel diseases of the brain underlie 20 to 30 percent ischemic strokes and a larger proportion intracerebral hemorrhages. In this report, we show that mutation in mouse Col4a1 gene, encoding procollagen type IV alpha1, predisposes both newborn adult mice hemorrhage. Surgical delivery mutant alleviated birth-associated trauma We identified COL4A1 human family with small-vessel disease. concluded may cause spectrum cerebrovascular phenotypes persons mutations be predisposed hemorrhage,...
Mammalian epidermis is maintained by stem cells that have the ability to self-renew and generate daughter differentiate along lineages of hair follicles, interfollicular sebaceous gland. As divide infrequently in adult mouse epidermis, they can be visualised as DNA label-retaining (LRC). With whole-mount labelling, we examine large areas many follicles simultaneously, enabling us evaluate cell markers effects different stimuli on LRC population. are not confined follicle, but also lie glands...
To better characterize aging in mice, the Jackson Aging Center carried out a lifespan study of 31 genetically-diverse inbred mouse strains housed specific pathogen-free facility. Clinical assessments were every 6 months, measuring multiple age-related phenotypes including neuromuscular, kidney and heart function, body composition, bone density, hematology, hormonal levels, immune system parameters. In concurrent cross-sectional same at 6, 12, 20 more invasive measurements followed by...
C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in life. This study was done to determine the T cell reactivity of candidate antigens might be involved their disease. CD4+ cells were strongly reactive enteric bacterial flora, but not epithelial or food antigens. The stimulatory material bacteria trypsin sensitive and restricted by class II major histocompatibility complex molecules, did have properties superantigen. precursor frequency interleuken...
Dextran sulfate sodium (DSS)-induced murine colitis represents an experimental model for human inflammatory bowel disease. The aim of this study was to screen various inbred strains mice genetically determined differences in susceptibility DSS-induced colitis. Mice C3H/HeJ, C3H/HeJBir, C57BL/6J, DBA/2J, NOD/LtJ, NOD/LtSz-Prkdc(scid)/Prkdc(scid), 129/SvPas, NON/LtJ, and NON.NOD-H2g7 were fed 3.5% DSS drinking water 5 days necropsied 16 later. Ceca colons scored histological lesions based on...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethyl 4-mercaptobutyrimidate as a cleavable crosslinking reagent and its application to the Escherichia coli 30S ribosomeRobert R. Traut, Alex Bollen, Tung-Tien Sun, John W. B. Hershey, Sundberg, L. Ross PierceCite this: Biochemistry 1973, 12, 17, 3266–3273Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August...
We have analyzed the possible role of aryl-hydrocarbon receptor (AHR) in aging process mice using a homozygous null mouse (Ahr-/-) line as model. studied 52 male and female Ahr-/- aged from 6-13 months. Forty-six percent died or were ill by 13 months age. developed age-related lesions several organs, some which apparent after only 9 Cardiovascular alterations included cardiomyopathy (100%) with hypertrophy focal fibrosis. Vascular mild fibrosis found portal areas liver (81%), vascular...
The Notch signaling pathway is an evolutionarily conserved mechanism and mutations in its components disrupt cell fate specification embryonic development many organisms. To analyze the vivo role of Notch3 gene mice, we created a deletion allele by targeting. Embryos homozygous for this mutation developed normally mutant adults were viable fertile. We also examined whether could detect genetic interactions during early embryogenesis between targeted Notch1 gene. Double embryos exhibited...