A5075752283- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Platelet Disorders and Treatments
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Allergic Rhinitis and Sensitization
- Electronic Packaging and Soldering Technologies
- Cancer and Skin Lesions
- Wnt/β-catenin signaling in development and cancer
- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Genetic and rare skin diseases.
- Contact Dermatitis and Allergies
- Advancements in Transdermal Drug Delivery
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Psoriasis: Treatment and Pathogenesis
- 3D IC and TSV technologies
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Immunotherapy and Immune Responses
- Barrier Structure and Function Studies
RIKEN Center for Integrative Medical Sciences
2016-2025
Keio University
2016-2025
Keio University Hospital
2014-2024
Charité - Universitätsmedizin Berlin
2023
Clinical Research Management
2022
Keiai University
2021
University of Manchester
2020-2021
Tochigi Prefectural Fisheries Experimental Station
1997-2021
Tochigi Prefectural Police
2013-2021
Weatherford College
2020
BackgroundRecent studies have suggested that epidermal barrier dysfunction contributes to the development of atopic dermatitis (AD) and other allergic diseases.ObjectiveWe performed a prospective, randomized controlled trial investigate whether protecting skin with moisturizer during neonatal period prevents AD sensitization.MethodsAn emulsion-type was applied daily first 32 weeks life 59 118 neonates at high risk for (based on having parent or sibling AD) who were enrolled in this study....
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune skin diseases caused by autoantibodies against desmoglein (Dsg) 3 Dsg1, respectively. Routine immunofluorescence testing of serum from patients cannot distinguish between these two severe since both have IgG Abs directed keratinocyte cell surfaces. In this study, recombinant Dsg3 produced as secreted proteins baculovirus expression, been utilized to develop ELISAs for the specific characterization their autoantibodies. Of 49...
Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients vulgaris (PV) develop membranes and/or skin. PF and PV are due to loss of keratinocyte cell–cell adhesion in the superficial deep epidermis, respectively. autoantibodies directed against desmoglein (Dsg) 1; bind Dsg3 or both Dsg1. In this study, we test hypothesis that coexpression Dsg1 keratinocytes protects pathology antibody-induced dysfunction either one alone. Using passive transfer...
Outermost barriers are critical for terrestrial animals to avoid desiccation and protect their bodies from foreign insults. Mammalian skin consists of two sets barriers: stratum corneum (SC) tight junctions (TJs). How acquisition external antigens (Ags) by epidermal Langerhans cells (LCs) occur despite these has remained unknown. We show that activation-induced LCs elongate dendrites penetrate keratinocyte (KC) TJs survey the extra-TJ environment located outside TJ barrier, just beneath SC....
Abstract Background Parkinson’s disease (PD) is a neurodegenerative characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form PD, PARK2, caused mutations parkin gene. -knockout mouse models show some abnormalities, but they do not fully recapitulate pathophysiology human PARK2. Results Here, we generated induced pluripotent stem cells (iPSCs) from two PARK2 patients. iPSC-derived showed increased oxidative stress and enhanced activity...