A5064886028- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Electromagnetic Fields and Biological Effects
- Functional Brain Connectivity Studies
- Nanoparticle-Based Drug Delivery
- NMR spectroscopy and applications
- Characterization and Applications of Magnetic Nanoparticles
- Electrical and Bioimpedance Tomography
- Physics of Superconductivity and Magnetism
- MRI in cancer diagnosis
- Advanced Sensor and Energy Harvesting Materials
- Muscle activation and electromyography studies
- Superconducting Materials and Applications
- Photoreceptor and optogenetics research
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- EEG and Brain-Computer Interfaces
- Diamond and Carbon-based Materials Research
- Conducting polymers and applications
- Advanced NMR Techniques and Applications
- Neurological disorders and treatments
- Neural dynamics and brain function
Tokyo University of Information Sciences
2015-2024
The University of Tokyo
2015-2024
Kogakuin University
2020
Nippon Medical School Musashi Kosugi Hospital
2020
Chuo University
2020
European Neuroendocrine Tumor Society
2019
Osaka University
2012-2019
Aalto University
2019
Japan Science and Technology Agency
2014-2018
Information Systems Laboratories (United States)
2014
Significance We have successfully fabricated very unique ultraflexible temperature sensors that exhibit changes in resistivity by six orders of magnitude or more for a change only 5 °C less. Our approach offers an ideal solution to measure over large area with high spatial resolution, sensitivity 0.1 less, and fast response time 100 ms. Indeed, such our can significantly simplify the readout circuitry, which was key demonstrate, knowledge, world’s first successful measurement dynamic lung...
Significance We have developed a transparent, ultraflexible, and active multielectrode array (MEA), which consists of transparent organic electrochemical transistors Au grid wirings. The micropatterned showed 60% transparency at 475-nm wavelength. MEA the spatial mapping electrocorticogram electrical signals from an optogenetic rat with 1-mm spacing shows lower light artifacts than noise level.
In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet an aqueous hydrogel. This exhibits admittance 100 mS cm(-2) maintains even in low-frequency range. On implantation into living hypodermal tissue for 4 weeks, it showed small foreign-body reaction compared widely used...
High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts surface organs measure propagation spatial-temporal resolution; however, plastic substrates Young's modulus, causing difficulties in creating appropriate stretchability blood compatibility applying them on...
Abstract Accurate and unobtrusive monitoring of surface biopotentials is paramount importance for physiological studies wearable healthcare applications. Thin, light‐weight, conformal bioelectrodes are highly desirable biopotential monitoring. This report demonstrates the fabrication sub‐300 nm thin, dry electrodes that self‐adhesive conformable to complex 3D biological surfaces thus capable excellent quality (surface electromyogram electrocardiogram) recordings. Measurements reveal...
A unique form of adaptive electronics is demonstrated, which change their mechanical properties from rigid and planar to soft compliant, in order enable conformal wrapping around 3D objects, including biological tissue. These devices feature excellent robustness maintain initial electrical even after changing shape stiffness. As a service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online...
Integration of organic electrochemical transistors and field-effect is successfully realized on a 600 nm thick parylene film toward an electrophysiology array. A single cell integrated device 2 × array succeed in detecting electromyogram with local stimulation the motor nerve bundle transgenic rat by laser pulse.
Nanoparticle therapeutics are promising platforms for cancer therapy. However, it remains a formidable challenge to assess their distribution and clinical efficacy therapeutic applications. Here, by using multifunctional polymeric micellar nanocarriers incorporating clinically approved gadolinium (Gd)-based magnetic resonance imaging contrast agents platinum (Pt) anticancer drugs through reversible metal chelation of Pt, simultaneous therapy an orthotopic animal model intractable human...
Abstract We developed a novel magnetometer that employs negatively charged nitrogen-vacancy (NV − ) centers in diamond, to detect the magnetic field generated by nanoparticles (MNPs) for biomedical applications. The compact probe system is integrated into fiber-optics platform allowing design. To signals from MNPs effectively, we demonstrated, first time, application of an alternating current (AC) excitation coil several hundred microteslas magnetization diamond quantum sensing. In lock-in...
Magnetocardiography is a contactless imaging modality for electric current propagation in the cardiovascular system. Although conventional sensors provide sufficiently high sensitivity, their spatial resolution limited to centimetre-scale, which inadequate revealing intra-cardiac electrodynamics such as rotational waves associated with ventricular arrhythmias. Here, we demonstrate invasive magnetocardiography of living rats at millimetre-scale using quantum sensor based on nitrogen-vacancy...
We present a sensitive diamond quantum sensor with magnetic field sensitivity of $9.4\ifmmode\pm\else\textpm\fi{}0.1\phantom{\rule{0.2em}{0ex}}\mathrm{pT}/\sqrt{\mathrm{Hz}}$ in near-dc frequency range 5 to 100 Hz. This is based on the continuous-wave optically detected resonance an ensemble nitrogen-vacancy centers along [111] direction (111) single crystal. The long ${T}_{2}^{\ensuremath{\ast}}\ensuremath{\sim}2\phantom{\rule{0.2em}{0ex}}\text{\ensuremath{\mu}}\mathrm{s}$ our and reduced...
Abstract High‐density poly(ethylene glycol) (PEG)‐coated iron‐oxide–gold core–shell nanoparticles (AuIONs) were developed as T 2 ‐weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG‐coated (PEG‐AuIONs) approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments mice bearing subcutaneous colon model prepared C26 murine adenocarcinoma cells showed high accumulation of the PEG‐AuIONs within tumor mass and low nonspecific liver...
We have studied a 10 MW class fully superconducting synchronous machine for direct-drive wind turbine generators. This has been designed using two kinds of wires. Multifilament wires used armature windings. The DC field coils the rotor are made HTS tapes. Electromagnetic design generators carried out by FEM analysis. Analysis results show that output is achievable with less use tapes than having and copper Then, calculated AC losses low.
The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a probe is promising method for sentinel lymph node biopsy. In this study, novel handheld with permanent magnet and sensor to detect the nodes in breast cancer patients. An outstanding feature of precise positioning at null point magnet, leading highly sensitive measurements unaffected by strong ambient fields magnet. Numerical experimental results show that longitudinal length approximately 10 mm,...
Abstract Background Sentinel lymph node biopsy is a standard staging procedure for early axillary node‐negative breast cancer. As an alternative to the currently used radioactive tracers sentinel (SLN) detection during surgical procedure, number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed new handheld, cordless, and lightweight magnetic probe SPIO detection. Methods Resovist (SPIO nanoparticles) were detected by newly...
Significance We have developed an ultraflexible and MRI-compatible optogenetic stimulator using organic light emitting diodes (OLEDs), which activate channelrhodopsin-2–expressing neurons in transgenic animals. The OLEDs can be conformably attached to soft neuronal tissues, such as peripheral nerves or brain, the superior mechanical flexibility significantly reduces damages tissues. They are also compatible with neuroimaging techniques MRI, while allowing investigation of evoked activities...
A 64-channel surface electromyogram (EMG) measurement sheet (SEMS) with 2 V organic transistors on a 1 μm-thick ultra-flexible polyethylene naphthalate (PEN) film is developed for prosthetic hand control. The EMG electrodes must satisfy the following three requirements; high mechanical flexibility, electrode density and signal integrity. To achieve integrity, distributed shared amplifier (DSA) architecture proposed, which enables an in-situ amplification of myoelectric fourfold increase in...
Abstract Background Neuroinflammation is associated with many conditions that lead to dementia, such as cerebrovascular disorders or Alzheimer’s disease. However, the specific role of neuroinflammation in progression cognitive deficits remains unclear. To understand molecular mechanisms underlying these events we used a rodent model focal cerebral stroke, which causes hippocampus-dependent function. Methods Cerebral stroke was induced by middle artery occlusion (MCAO). Hippocampus-dependent...