A5102012600- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Breast Implant and Reconstruction
- Cancer and Skin Lesions
- Autopsy Techniques and Outcomes
- Medical Imaging Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- MRI in cancer diagnosis
- BRCA gene mutations in cancer
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
- Reconstructive Surgery and Microvascular Techniques
- Radiomics and Machine Learning in Medical Imaging
- Magnetic and transport properties of perovskites and related materials
- Magnetic properties of thin films
- Restraint-Related Deaths
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Radiation Dose and Imaging
- Forensic Entomology and Diptera Studies
Nippon Medical School Hospital
2016-2025
Nippon Medical School
2015-2024
Saitama Cancer Center
2011-2023
Gunma University Hospital
2005-2023
Tsukuba International University
2022
The University of Tokyo
1987-2020
Chiba Hokusou Hospital
2020
Nippon Sport Science University
2020
Nippon Medical School Musashi Kosugi Hospital
2020
Chuo University
2020
The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a probe is promising method for sentinel lymph node biopsy. In this study, novel handheld with permanent magnet and sensor to detect the nodes in breast cancer patients. An outstanding feature of precise positioning at null point magnet, leading highly sensitive measurements unaffected by strong ambient fields magnet. Numerical experimental results show that longitudinal length approximately 10 mm,...
Abstract Background Sentinel lymph node biopsy is a standard staging procedure for early axillary node‐negative breast cancer. As an alternative to the currently used radioactive tracers sentinel (SLN) detection during surgical procedure, number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed new handheld, cordless, and lightweight magnetic probe SPIO detection. Methods Resovist (SPIO nanoparticles) were detected by newly...
Refinement of the crystal structure is made for room temperature phases LaNbO4 and NdNbO4. The final R index 0.0457 0.0342 From precise atomic parameters, vectors shuffles all atoms out "the plane shear" (010) are determined. Since twins in crystals connected with parents by a new kind relation, that they folded only rotation about b-axis normal to shear, called "twins third kind". Die Kristallstruktur für die Raumtemperaturphasen von und NdNbO4 wird verbessert. Der definitive Index der...
In the present study, clinical tumor response following neoadjuvant chemotherapy (NAC) was diagnosed by magnetic resonance imaging (MRI) and clinicopathological factors, including molecular subtypes at baseline, were analyzed for correlations with pathological responses. addition, factors a correlation MRI capacity to predict complete (pCR). Clinical evaluated NAC determined as CR (cCR) or residual tumor. cCR confirmed if no gadolinium enhancement an equal less than that of glandular tissue...
Neoadjuvant chemotherapy (NAC) with taxanes followed by fluorouracil, epirubicin, and cyclophosphamide (FEC), concurrent trastuzumab is a potent regimen for HER2 over-expressing breast cancer. A high pathological complete response (pCR) rate has been achieved using this regimen; however, the predictive factors prognostic effects of pCR currently remain unclear. In present study, we determined whether was related to histological grade (HG) several biological including p27(Kip1). We also...
Treatment with an aromatase inhibitor for 5 years is the standard treatment postmenopausal hormone receptor-positive breast cancer. We investigated effects of extending this to 10 on disease-free survival (DFS).This prospective, randomized, multicenter open-label phase III study assessed effect anastrozole additional in patients who were after either alone or 2-3 tamoxifen followed by anastrozole. Patients allocated randomly (1:1) continue stop The primary end point was DFS, including cancer...
Although advances in neoadjuvant chemotherapy (NAC) are improving the rate of pathological complete response (pCR) and outcomes for triple-negative breast cancer (TNBC) patients, prognosis remains poor. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression was recently reported to be associated with resistance poor TNBC. We evaluated IMP3 40 female TNBC patients assess its association NAC sensitivity outcome. Among cohort, 11 (27.5%) had IMP3-positive TNBC, which a higher...
A 51-year-old woman with known dextrocardia presented left-sided abdominal pain and symptoms consistent biliary colic cholelithiasis. Abdominal ultrasound confirmed the diagnosis of gallstones, as well situs inversus liver gallbladder on left side spleen right. Laparoscopic cholecystectomy was performed without incident. The procedure uncomplicated except for being mirror image that done in normal location. Cholelithiasis occurring is rare may present a diagnostic problem. extrahepatic...
Aromatase inhibitor shows efficacy for hormone receptor positive postmenopausal breast cancer. We evaluated the activity of 24 weeks aromatase inhibition with exemestane primary cancer in a neoadjuvant setting. Patients stage II/IIIA invasive estrogen (ER) and/or progesterone (PgR)‐positive status were eligible. Primary endpoints objective response rate (ORR) and safety. A steroidal 25 mg/day was administered 16 an 8‐week extension. Secondary rates breast‐conserving surgery (BCS), change...
Journal Article Diagnostic reference level of computed tomography (CT) in japan Get access Yasuhiro Fukushima, Fukushima * 1Department Radiology, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma, Japan *Corresponding author: yfukushi@gunma-u.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshito Tsushima, Tsushima 2Department Radiology and Nuclear Medicine, Hiroyuki Takei, Takei Ayako Taketomi-Takahashi, Taketomi-Takahashi Hidenori Otake,...
Computed tomography (CT) is the largest source of medical radiation exposure to general population, and considered a potential increased cancer risk. The aim this study was assess current situation CT use in Japan, investigate variations studies among institutions scanners. Data-sheets were sent all 126 hospitals randomly selected 14 (15%) 94 clinics Gunma prefecture which had scanner(s). Data for patients undergoing during single month (June 2008) obtained, along with scan protocols each...
BackgroundIn this study we investigated if the 21-gene assay result affects adjuvant decision-making in Japanese women with ER+ invasive EBC.Patients and MethodsA total of 124 consecutive eligible patients ER+, HER2-negative EBC 0 to 3 positive lymph nodes were enrolled. Treatment recommendations, physicians' confidence patients' decisional conflict before after knowledge Recurrence Score results recorded.ResultsOne-hundred four (84%) had N0 disease, including micrometastases, 20 (16%) N+...
Neoadjuvant endocrine therapy (NAE) has been employed to improve surgical outcomes for hormone receptor-positive breast cancers in postmenopausal women. Endocrine responsiveness is estimated by expressions of receptors, but its heterogeneity recognized. Autophagy an evolutionally conserved process associated with cell survival and death implicated cancer treatment. In order examine the possible association between autophagy response therapy, we evaluated status autophagy-associated markers,...
Purpose: CYP2D6 is the key enzyme responsible for generation of potent active metabolite tamoxifen, "endoxifen." There are still controversial reports questioning association between genotype and tamoxifen efficacy. Hence, we performed a prospective multicenter study to evaluate clinical effect on therapy.Experimental Design: We enrolled 279 patients with hormone receptor-positive human epidermal growth factor receptor 2-negative, invasive breast cancer receiving preoperative monotherapy 14...
Immunohistochemically detected metallothionein expression [MT(+)] was shown to be related aggressive behavior of the invasive ductal carcinoma breast. In this study, MT examined immunohistochemically in 92 cases breast and compared with demonstrated estrogen receptor (ER), c-erbB-2, Ki-67 status clinocopathological characteristics. Of examined, 27.1% (25 cases) were MT(+), high percentages solid tubular subtype (47%), medullary (80%), carcinomas spindle cell metaplasia (100%) positive for...
Abstract In postmenopausal breast cancers, locally produced estrogen by adipose stromal cells causes the progression of tumor growth. Although aromatase, a key enzyme synthesis, is highly expressed in cells, and aromatase inhibitors show greater efficacy mechanism increasing activity remains unclear. To analyze signals to detect receptor (ER)–activating ability for individual human we developed new reporter cell system. visualize activation ER, first established stable transformant, named...