A5063623048- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- AI in cancer detection
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- Digital Radiography and Breast Imaging
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Molecular Biology Techniques and Applications
- MRI in cancer diagnosis
- Genomic variations and chromosomal abnormalities
- Bone health and treatments
- Cancer-related Molecular Pathways
- Nutrition, Genetics, and Disease
Japanese Red Cross Nagoya Daiichi Hospital
2020-2024
Japanese Foundation For Cancer Research
2013-2023
The Cancer Institute Hospital
2010-2019
Social Insurance Saitama Chuo Hospital
2019
Nagoya Medical Center
2019
National Hospital Organization
2019
Saitama Cancer Center
2019
Ibaraki Prefectural Central Hospital
2019
Japan Cancer Society
2009-2017
Cancer Institute (WIA)
2007-2017
Detection of sentinel lymph node (SLN) metastasis in breast cancer patients has conventionally been determined by intraoperative histopathologic examination frozen sections followed definitive postoperative permanent sections. The purpose this study is to develop a more efficient method for detection metastasis.Cutoff values distinguish macrometastasis, micrometastasis, and nonmetastasis were measuring cytokeratin 19 (CK19) mRNA histopathologically positive negative nodes using one-step...
The clinicopathologic importance of a second estrogen receptor (ER), ER-beta, in breast cancers has been intensely studied; however, there is still no real consensus regarding the clinical utility an ER-beta assay, probably because lack standardized methodology, presence several isotypes (ER-beta1-5, and so on), and, more importantly, convincing data on whether status provides clinically useful information over what already provided by traditional ER-alpha/progesterone (PR) assay. A large...
Accurate assessment of metastasis in sentinel lymph nodes (SLN) breast cancer is important but involves a heavy workload for the pathologist. We conducted multicenter clinical trial Japan to evaluate new automated assay system cytokeratin 19 mRNA, one-step nucleic acid amplification (OSNA) (Sysmex), detect node cancer.Surgically obtained axillary were sectioned into four pieces, two which examined with OSNA assay. The other adjacent pieces H&E and immunohistochemical staining 19. Serial...
Abstract BACKGROUND: Conventional histopathological examination is limited in measuring accurate total metastatic volume a lymph node. Recently, molecular‐based procedure to detect node metastases, one‐step nucleic acid amplification (OSNA) assay, has been developed. OSNA assay can assess whole and yields semiquantitative results. The authors compared the performance intraoperative detection of sentinel metastases with using versus routine frozen section (FS) histology 2 mm‐sectioned...
Bcl-2 plays an anti-apoptotic role, resulting in poor clinical outcome or resistance to therapy most tumor types expressing Bcl-2. In breast cancer, however, expression has been reported be a favorable prognostic factor. The positive correlation of with estrogen receptor (ER)/progesterone (PR) status, and endocrine frequently given for hormone receptor-positive tumors, may obscure the independent pathobiological role We constructed large systematic study determine whether cancer.Bcl-2 was...
Purpose To evaluate the association between tumor shrinkage patterns shown with magnetic resonance (MR) imaging during neoadjuvant chemotherapy (NAC) and prognosis in patients low-grade luminal breast cancer. Materials Methods This retrospective study was approved by institutional review board informed consent obtained from all subjects. The cancer defined as hormone receptor-positive human epidermal growth factor receptor 2-negative nuclear grades 1 or 2. of revealed at MR were categorized...
A pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is a signature of favorable prognosis in breast cancer. The aim this study was assess the accuracy magnetic resonance imaging (MRI) predicting pCR after NAC. 265 women with stage II or III cancer who underwent surgery NAC were retrospectively investigated for MRI findings before and Correlation an "imaging response" (iCR), defined as no detectable tumor on all serial images dynamic contrast-enhanced T1-weighted imaging,...
Treatment with an aromatase inhibitor for 5 years is the standard treatment postmenopausal hormone receptor-positive breast cancer. We investigated effects of extending this to 10 on disease-free survival (DFS).This prospective, randomized, multicenter open-label phase III study assessed effect anastrozole additional in patients who were after either alone or 2-3 tamoxifen followed by anastrozole. Patients allocated randomly (1:1) continue stop The primary end point was DFS, including cancer...
Secretory carcinoma (SC) is a rare histological type of breast cancer, and ETV6-NTRK3 gene fusion highly specific to it. The differential diagnoses SC include acinic cell (ACCA) cystic hypersecretory (CHC), as well invasive ductal (IDC). For patients with these but distinctive subtypes, its histopathological mimics should be differentiated from each other. However, markers have not yet been assessed systematically, we aimed identify evaluate novel existing markers.We reviewed 19 cases...
Panel sequencing of susceptibility genes for hereditary breast and ovarian cancer (HBOC) syndrome has uncovered numerous germline variants; however, their pathogenic relevance ethnic diversity remain unclear. Here, we examined the prevalence variants among 568 Japanese patients with
Abstract BACKGROUND: There is limited information about the risk factors for ipsilateral breast tumor recurrence (IBTR) after patients undergo breast‐conserving surgery plus radiotherapy (breast‐conserving treatment [BCT]) subsequent to neoadjuvant chemotherapy (NAC). The objective of current study was analyze these factors. METHODS: authors collected data from 375 who underwent BCT and received NAC analyzed IBTR associated with undergoing NAC. usefulness MD Anderson Prognostic Index (MDAPI)...
We present a case of metastatic breast cancer patient with cystoid macular edema (CME) occurring during treatment paclitaxel and bevacizumab. She had history neoadjuvant chemotherapy partial mastectomy plus axillary lymph node dissection for stage IIB left-breast cancer. Twenty-four months later, she was diagnosed multiple bone metastases underwent Thirty-three after the initiation chemotherapy, noticed bilateral blurred vision. The retinal thickening observed by optical coherence...