A5064489470- Breast Cancer Treatment Studies
- Epilepsy research and treatment
- Breast Lesions and Carcinomas
- Pharmacological Effects and Toxicity Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Advanced Breast Cancer Therapies
- Bone health and treatments
- Bone Metabolism and Diseases
- Chemotherapy-related skin toxicity
- Ultrasound and Hyperthermia Applications
- Genomics and Rare Diseases
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
Hiroshima University
2006-2025
Kure Medical Center
2017-2024
National Hospital Organization
2017-2024
Hiroshima University Hospital
2011-2024
National Epilepsy Center
2000-2023
Kihoku hospital
2019
Wakayama Medical University
2010-2019
Onomichi General Hospital
2016
Hiroshima Prefectural Hospital
2016
Hiroshima City Asa Citizens Hospital
2016
Abstract Objective Gaucher disease (GD) is a lysosomal storage characterized by deficiency of glucocerebrosidase. Although enzyme‐replacement and substrate‐reduction therapies are available, their efficacies in treating the neurological manifestations GD negligible. Pharmacological chaperone therapy hypothesized to offer new strategy for this disease. Specifically, ambroxol, commonly used expectorant, has been proposed as candidate pharmacological chaperone. The purpose study was evaluate...
Summary Objective This study attempted to clarify the long‐term course of D ravet syndrome ( DS ). Methods Sixty‐four patients diagnosed with (44 typical , and 20 atypical ) were studied. The outcomes clinical seizures, electroencephalographic findings, neuropsychological social situation analyzed. follow‐up period ranged from 11 34 years 5 months (median 24 years). Results At last visit, ages 19 45 30 Fifty‐nine continued have generalized tonic–clonic seizures GTCS Status epilepticus...
Postoperative prognosis is better for hormonal receptor-positive breast cancer than other phenotypes; however, there are no definitive predictive factors relapse or survival. This study aimed to evaluate the maximum standardized uptake value (SUVmax) on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) and clinicopathological characteristics as possible predictors of postoperative relapse-free survival (RFS) overall (OS) in patients. We evaluated 262...
Abstract Purpose This randomized phase II study was conducted to investigate the efficacy of cryotherapy in preventing peripheral neuropathy and dermatological adverse events breast cancer patients treated with weekly paclitaxel. Methods Patients 12 doses paclitaxel for were (1:1) into a or control group. The primary endpoint percentage marked decrease Functional Assessment Cancer Therapy-Neurotoxicity (FACT-NTX) score. secondary endpoints Patient Neurotoxicity Questionnaire (PNQ), Common...
FOXP3 + and CD8 are recognized markers of tumor-infiltrating lymphocytes (TILs) for breast cancer. TILs composed effector Tregs (eTregs) other subpopulations that classified by their differences in suppressive function. In this prospective study, we evaluated Treg cancer.84 patients with cancer were enrolled. Fresh extracted andTregs into eTregs (CD4+FOXP3highCD45RA-), FOXP3+ subsets (naïve non-Tregs), total CD8+CD4- using flow cytometry. The suppression strength each subpopulation was...
Radiofrequency ablation (RFA) is considered a promising alternative to surgical excision for patients with small, unifocal early-stage breast cancer. A significant concern the application of RFA in diagnosed ductal carcinoma situ (DCIS) via needle biopsy underdiagnosis invasive The extent this DCIS eligible has not been clearly defined. This retrospective study assessed lesions as and at our institution from April 2009 March 2024. eligibility criteria included lesion size ≤ 1.5 cm,...
The aim of this study was to evaluate the significance (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for speculating malignant level and prognostic value operable breast cancers.Of 578 consecutive patients with primary invasive cancer who underwent curative surgery between 2005 2010, 311 (53.8%) received FDG-PET/CT before initial therapy were examined.Receiver operating characteristics (ROC) curve analysis showed cutoff maximum standardized uptake...
We aimed to determine whether contrast-enhanced ultrasonography can predict the effects of neoadjuvant chemotherapy on breast cancer.The clinical responses 63 consecutive patients with cancer (T1-4, N0-1, M0) between October 2012 and May 2015 were assessed using magnetic resonance imaging, positron emission tomography/computed tomography ultrasonography. Perfusion parameters for created from time-intensity curves based enhancement intensity temporal changes objectively evaluate findings. The...
The subject of this study was a total 48 epileptic falls or drop attacks in 15 children, captured by self-tracking video monitoring system. A fall defined as complete loss the maintenance either standing sitting posture, which took place within 1 s. patients with falling thus fulfilled diagnostic criteria Lennox-Gastaut syndrome. Through precise analysis ongoing sequence from onset to completion fall, it possible classify them into following four types: (a) tonic type, 9 five patients; (b)...
Abstract BACKGROUND: There is limited information about the risk factors for ipsilateral breast tumor recurrence (IBTR) after patients undergo breast‐conserving surgery plus radiotherapy (breast‐conserving treatment [BCT]) subsequent to neoadjuvant chemotherapy (NAC). The objective of current study was analyze these factors. METHODS: authors collected data from 375 who underwent BCT and received NAC analyzed IBTR associated with undergoing NAC. usefulness MD Anderson Prognostic Index (MDAPI)...
Abstract We have previously reported the synergistic cytotoxic effects of Docetaxel (TXT) and S‐1 in gastric cancer vitro vivo , combination regimen is now under phase III clinical trail. In this study, to elucidate whether rapamycin, inhibitor mTOR (mammalian target rapamaycin), can enhance potentiation TXT 5‐fluorouracil (5‐Fu) carcinoma cells. Rapamycin inhibited growth TMK‐1, MKN‐28, MKN‐45 MKN‐74 cell lines by MTT assay, it demonstrated cytostatic as G1 arrest shown flowcytometry....
// Hideo Shigematsu 1 , Shinji Ozaki Daisuke Yasui Hideki Yamamoto 2 Junichi Zaitsu Daiki Taniyama Akihisa Saitou Kazuya Kuraoka Taizo Hirata 3 and Kiyomi 4 Department of Breast Surgery, National Hospital Organization Kure Medical Center Chugoku Cancer Center, Kure-City, Hiroshima, Japan Pathology, Oncology, Correspondence to: Shigematsu, email: shigematu1330@yahoo.co.jp Keywords: breast cancer; topoisomerase IIA; prognostic value; luminal B Received: April 04, 2018 Accepted: May 05,...
We developed a new procedure called hybrid endoscopy-assisted breast-conserving surgery (EBCS), which consists of combination plastic and endoscopic techniques. The purpose this study was retrospectively to analyze the clinical outcome EBCS compare cosmetic outcomes between conventional (CBCS).We reviewed medical records patients who had undergone (n=73) or CBCS (n=90) May 2005 April 2011 been followed up in our department until March 2012. these two groups were compared. safety also...
It is unclear whether individualized treatments based on biological factors have improved the prognosis of recurrent breast cancer. The purpose this study to evaluate survival improvement patients with cancer after introduction third generation aromatase inhibitors (AIs) and trastuzumab.A total 407 who received first diagnosis treatment at National Kyushu Cancer Center between 1992 2008 were retrospectively evaluated. As AIs trastuzumab approved for clinical use in Japan 2001, divided into...
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of weekly paclitaxel-based chemotherapy for breast cancer, that can persist years. Cryotherapy therapy effective preventing early CIPN, but its protective on persistent CIPN uncertain. This cross-sectional study conducted as an ancillary analysis randomized trial investigating the preventive cryotherapy in cancer patients receiving (UMIN000034966). Eligible were evaluated at more than year after completion (persistent...
Background Peritumoral edema (PE) identified on T2‐weighted breast MRI is a factor for poor prognosis in cancer. Purpose To assess the prognostic value of residual PE (rPE) patients with positive cancer prior to neoadjuvant chemotherapy (NACT) who subsequently underwent curative surgery. Study Type Retrospective. Population In total, 128 nonmetastatic invasive before and after NACT. Field Strength/Sequence Axial precontrast 2D fast spin echo T2W fat‐suppressed sequence. dynamic 3D gradient...