A5014897168- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- EEG and Brain-Computer Interfaces
- Bacterial Infections and Vaccines
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Multiple Sclerosis Research Studies
- Lysosomal Storage Disorders Research
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Trypanosoma species research and implications
- Vascular Malformations and Hemangiomas
- RNA regulation and disease
- Streptococcal Infections and Treatments
- Vagus Nerve Stimulation Research
- Ophthalmology and Eye Disorders
- Viral Infections and Immunology Research
- Hereditary Neurological Disorders
- Erythrocyte Function and Pathophysiology
- Vascular Malformations Diagnosis and Treatment
Hiroshima City Asa Citizens Hospital
2019-2025
Citizens Specialty Hospitals
2025
Hiroshima Prefectural Hospital
2022
Seirei Hamamatsu General Hospital
2018-2021
Tottori University
2014-2017
City Hospital
2011
Abstract Objective Gaucher disease (GD) is a lysosomal storage characterized by deficiency of glucocerebrosidase. Although enzyme‐replacement and substrate‐reduction therapies are available, their efficacies in treating the neurological manifestations GD negligible. Pharmacological chaperone therapy hypothesized to offer new strategy for this disease. Specifically, ambroxol, commonly used expectorant, has been proposed as candidate pharmacological chaperone. The purpose study was evaluate...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sometimes triggers encephalopathy as a serious neurological complication in children. We previously reported the clinico-radiological findings of SARS-CoV-2-associated encephalopathy. The advent SARS-CoV-2 omicron variant led to marked increase pediatric patients with disease 2019 (COVID-19); however, epidemiological changes according emergence have not yet been documented. Therefore, present study investigated differences during...
The patient was a 21-year-old female. She had frequently status seizures when she fever or while taking bath since 6 months old. At 1 year and 8 old, developed epilepsy. treated with multiple antiepileptic drugs, but her condition intractable. the age of 3, suffered from acute encephalopathy, which complicated by severe psychomotor developmental retardation. Tonic continued to occur on daily basis even after school age, they did not worsen during periods fever, hospitalized until 8. 19,...
For patients with infantile epileptic spasms syndrome (IESS) who have achieved remission of (ES), indicators how well the electroencephalographic (EEG) state should be maintained during follow-up are not available. We hypothesized that time course Burden Amplitudes and Epileptiform Discharges (BASED) score after ES is associated relapse. This study aimed to investigate association between relapse BASED scores at initial subsequent period. collected clinical digital EEG data four hospitals...
Abstract We aimed to analyse the ictal electrographic changes on scalp electroencephalography (EEG), focusing high-voltage slow waves (HVSs) in children with epileptic spasms (ES) and tonic (TS) then identified factors associated corpus callosotomy (CC) outcomes. enrolled 17 patients ES/TS who underwent CC before 20 years of age. Post-CC Engel’s classification was as follows: I 7 patients, II 2, III 4, IV 4. Welch’s t-test used correlation between HVSs outcomes based following three...
Abstract Objectives Long‐term adrenocorticotropic therapy (LT‐ACTH), which consisted of 2‐4 weeks daily injections hormone (ACTH) and subsequent months weekly injections, was tried for relapsed West syndrome (WS) or other intractable epilepsies in small case reports. Our aim to explore the efficacy LT‐ACTH preventing WS relapse, as well prevalence its adverse events. Methods This is a retrospective, nationwide, multicenter series patients with who underwent LT‐ACTH. Clinical information...
Hemiconvulsion-hemiplegia-epilepsy syndrome (HHES) is a subset of acute encephalopathy characterized by infantile-onset with hemiconvulsive febrile status and subsequent unilateral cerebral atrophy hemiparesis. In the chronic phase, patients HHES develop epilepsy, typically displayed as intractable focal seizures. The are often antiepileptic drugs need surgical treatment. Although viral encephalitis genetic abnormalities presumed to be underlying etiology, pathogenesis remains mostly...
Abstract We describe the efficacy of high-dose barbiturates and early administration a parenteral ketogenic diet (KD) as initial treatments for acute status epilepticus (SE) in an 8-year-old girl with febrile infection-related epilepsy syndrome (FIRES). The patient was admitted to our hospital refractory focal SE. Abundant epileptic discharges over left frontal region were observed on electroencephalogram (EEG). Treatment continuous infusion thiamylal 4 hours, increased incrementally 40...
Diagnosing epilepsy in the elderly population can be difficult due to mimicking symptoms. Furthermore, epileptic symptoms also masked by various We hypothesized that patients with exhibit specific clinical features among symptoms.From 2009 2017, 177 who were older than 65 years referred our center. Out of this group, onset occurred after reaching age 50 152 patients, additionally being treated at clinic. divided their accordance consciousness levels, which defined as follows: full...
Abstract We present the case of a 5‐year‐old‐boy who developed fever and cellulitis‐like groin rash 5 days before developing conjunctivitis 6 to 7 other typical signs Kawasaki disease (KD) appeared. The cellulitis failed respond antibiotics no pathogens were isolated. His clinical resolved with intravenous immunoglobulin high‐dose aspirin after discontinuation antibiotics. Nonbacterial is rare presenting sign KD, but in appropriate setting population, diagnosis KD should be considered when...
Panayiotopoulos syndrome (PS) is a self-limited focal epilepsy appearing in childhood. Seizures PS are self-limiting and do not usually continue into adulthood. Juvenile myoclonic (JME) the most common type of idiopathic generalized epilepsy, developing around puberty continuing throughout We describe four cases childhood which JME developed adolescence. Age at onset ranged from 4 to 8 years for PS, 11 14 JME. after subsided, with interval between last seizure first ranging 1 10 years. No...