A5028183017- Bone Metabolism and Diseases
- Heat shock proteins research
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Congenital Diaphragmatic Hernia Studies
- Autoimmune Neurological Disorders and Treatments
- Infectious Encephalopathies and Encephalitis
- Calpain Protease Function and Regulation
- Epilepsy research and treatment
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
- Esophageal and GI Pathology
- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- Platelet Disorders and Treatments
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Peripheral Neuropathies and Disorders
- Prenatal Screening and Diagnostics
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Polyomavirus and related diseases
- Pancreatic function and diabetes
- Genomics and Rare Diseases
Yamaguchi University
2017-2025
Osaka City General Hospital
2019-2024
Tokuyama (Japan)
2024
Nara Prefecture General Medical Center
2023
Nara Medical University
2023
Nagoya City University
1987-2021
Gifu University
2012-2018
Saiseikai Shimonoseki General Hospital
2018
Nagoya University
2016-2017
Hamamatsu Medical Center
2015
Spontaneously hypertensive rats (SHR) and normotensive control, Wistar/Kyoto (WKY) through two generations were fed a semipurified diet supplemented either with safflower oil (rich in linoleate) or perilla alinolenate).The cerebral lipid contents phospholipid compositions did not differ between the dietary groups of S H R rats.There also no differences unsaturated/saturated ratios individual phospholipids proportions plasmalogens.However, (n-3) (n-6) fatty acids significantly...
Donryu strain rats through two generations were fed semi-purified diets supplemented with safflower seed oil (rich in linoleic acid) or perilla a-linolenic acid), a conventional laboratory chow (normal control diet).Brightnessdiscrimination learning ability was determined to be the highest oil-fed group, followed by normal and then extending our earlier observation different of rat that acid is factor maintaining high (Yamamoto, N., M. Saitoh, 'To whom correspondence should addressed.'Fatty...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sometimes triggers encephalopathy as a serious neurological complication in children. We previously reported the clinico-radiological findings of SARS-CoV-2-associated encephalopathy. The advent SARS-CoV-2 omicron variant led to marked increase pediatric patients with disease 2019 (COVID-19); however, epidemiological changes according emergence have not yet been documented. Therefore, present study investigated differences during...
Resveratrol, which is found in grape and berry skins red wine, generally known to be beneficial for human health due its anti‑inflammation antioxidant effects. We have recently reported that transforming growth factor‑β (TGF‑β) stimulates vascular endothelial factor (VEGF) synthesis through Smad‑independent pathways, such as the p38 mitogen‑activated protein (MAP) kinase, p44/p42 MAP kinase stress‑activated kinase/c‑Jun N‑terminal (SAPK/JNK) osteoblast‑like MC3T3‑E1 cells. The aim of present...
Resveratrol is well known as a natural polyphenol abundantly found in red wine. We previously reported that bone morphogenetic protein-4 (BMP-4) stimulates vascular endothelial growth factor (VEGF) synthesis via p70 S6 kinase osteoblast-like MC3T3-E1 cells. In the present study, we investigated effect of resveratrol on BMP-4-stimulated VEGF significantly suppressed release and expression levels mRNA. SRT1720, an activator SIRT1 with potencies greater than resveratrol, also reduced mRNA...
It is firmly established that resveratrol, a natural food compound abundantly found in grape skins and red wine, has beneficial properties for human health. In the present study, we investigated effect of basic fibroblast growth factor (FGF-2) on osteoprotegerin (OPG) synthesis osteoblast-like MC3T3-E1 cells whether resveratrol affects OPG synthesis. FGF-2 stimulated both release expression mRNA. Resveratrol significantly suppressed FGF-2-stimulated mRNA levels OPG. SRT1720, an activator...
Resveratrol is a naturally occurring polyphenol that possesses health‑related properties, and predominantly found in grapes berries. Bone morphogenetic protein‑4 (BMP‑4) stimulates osteocalcin synthesis via p38 mitogen‑activated protein (MAP) kinase osteoblast‑like MC3T3‑E1 cells. The present study aimed to investigate the effects of resveratrol on BMP‑4‑induced osteoprotegerin (OPG) alone had no effect OPG expression levels, but significantly enhanced release. In addition, markedly...
Polyphenolic compounds in foods and beverages have beneficial effects on human health. (-)-Epigallocatechin gallate (EGCG) chlorogenic acid (CGA), a major flavonoid green tea phenolic coffee, respectively, potent properties, including antioxidative effects. Our previous study demonstrated that p70 S6 kinase acts as negative regulator tumor necrosis factor-α (TNF-α)-stimulated interleukin-6 synthesis osteoblast-like MC3T3-E1 cells. In the present study, of EGCG CGA TNF‑α‑stimulated...
Heat shock protein 27 (HSP27/HSPB1), one of the small heat proteins, is constitutively expressed in various tissues. HSP27 and its phosphorylation state participate regulation multiple physiological pathophysiological cell functions. However, exact roles osteoblasts remain unclear. In present study, we investigated role platelet-derived growth factor‑BB (PDGF‑BB)‑stimulated migration osteoblast-like MC3T3-E1 cells. PDGF-BB by itself barely upregulated expression protein, but stimulated these...
Resveratrol is a natural polyphenol found in red grape skins, berries and wine. Accumulating evidence suggests that resveratrol has various beneficial effects on the human body. In present study, we investigated of prostaglandin E2 (PGE2) osteoprotegerin (OPG) synthesis OPG osteoblast-like MC3T3-E1 cells. PGE2 significantly stimulated both release mRNA expression levels OPG, as shown by assay real-time RT-PCR, respectively. markedly suppressed induced PGE2. On contrary, SRT1720, an activator...
Incretins including glucagon-like peptide-1 (GLP-1) and glucose‑dependent insulinotropic polypeptide (GIP) secreted from the small intestine after oral food ingestion are currently recognized to stimulate insulin secretion pancreatic β cells. We previously reported that p70 S6 kinase limits tumor necrosis factor‑α (TNF‑α)‑stimulated interleukin-6 (IL‑6) synthesis in osteoblast‑like MC3T3‑E1 In present study, we investigated effects of incretins on TNF‑α‑induced IL‑6 underlying mechanism...
Heat shock protein 90 (HSP90) that is ubiquitously expressed in various tissues, recognized to be a major molecular chaperone. We have previously reported prostaglandin F2α (PGF2α), potent bone remodeling mediator, stimulates the synthesis of interleukin-6 (IL-6) through p44/p42 mitogen-activated (MAP) kinase and p38 MAP osteoblast-like MC3T3-E1 cells, Rho-kinase acts at point upstream kinase. In present study, we investigated involvement HSP90 PGF2α-stimulated IL-6 underlying mechanism...
Chlorogenic acid (CGA) is a primary phenolic component of coffee and (-)-epigallocatechin gallate (EGCG) flavonoid green tea, both which have been documented to possess beneficial health properties. A previous study by the present authors demonstrated that p38 mitogen-activated protein kinase (MAPK) may be associated with osteoprotegerin synthesis stimulated bone morphogenetic protein-4 (BMP-4) in osteoblast-like MC3T3-E1 cells. In study, effects CGA EGCG on BMP-4-stimulated cells were...
Purpose To delineate the characteristics of probable antibody-negative pediatric autoimmune encephalitis (probable Ab-negative AE), we compared clinical features AE to those major antibody-positive AE. Methods We retrospectively reviewed 18 patients with AE, 13 anti-N-methyl-D-aspartate receptor (NMDARE), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Clinical characteristics, neuroimaging findings, treatments, outcomes were analyzed. Results The age onset...
A 78-year-old man was diagnosed with right middle lobe lung cancer, complicated by partial anomalous pulmonary venous connection (PAPVC) in the upper vein. After resection, there concern about risk of heart failure (RHF) due to increased and left shunting. artery occlusion test using a catheter determined systemic blood flow ratio be 1.30; predicted value after lobectomy 1.51. The developing RHF low. Therefore, thoracoscopic performed without PAPVC repair; did not occur postoperatively....
Background: Cell sheet therapy has been developed as an effective regenerative medicine to improve wound repair treatment and prevent postoperative complications. Fibroblasts are widely used create cell engineering because of their essential role in tissue regeneration the acceleration healing process. Aim: The study aimed establish multilayered fibroblast sheets from canine fibroblast. Methods: fibroblasts three origin tissues, including oral mucosa, skin, tail skin. A was produced using...
A case of pemphigus foliaceus arising during the administration d-penicillamine was reported. 72-year-old woman with systemic sclerosis developed flaccid vesicles and crusted erythema skin after for 1-year. She positive anti-desmoglein 1 IgG by ELISA. The withdrawal resulted in improvement lesions ELISA scores anti-demoglein antibodies revealed a surprisingly rapid decline. This is classical incidence drug-induced foliaceus, which constantly required not only to induce, but also maintain...