A5056343821- Autoimmune Neurological Disorders and Treatments
- Infectious Encephalopathies and Encephalitis
- Epilepsy research and treatment
- Peripheral Neuropathies and Disorders
- Bacterial Infections and Vaccines
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- RNA regulation and disease
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Cancer Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Polyomavirus and related diseases
- Neurological and metabolic disorders
- Gastrointestinal disorders and treatments
- Neonatal and fetal brain pathology
- T-cell and B-cell Immunology
Tokyo Metropolitan Institute of Medical Science
2016-2025
Tokyo Women's Medical University
2021-2025
Tokyo Women's Medical University Yachiyo Medical Center
2021-2025
Niigata University
2023
Saitama Prefectural Kumagaya Girls High School
2021
Tokyo Metropolitan Neurological Hospital
2021
Aichi Medical University
2021
KK Women's and Children's Hospital
2021
Houju Memorial Hospital
2007-2018
National Center of Neurology and Psychiatry
2005-2017
To create an international consensus treatment recommendation for pediatric NMDA receptor antibody encephalitis (NMDARE).After selection of a panel 27 experts with representation from all continents, 2-step Delphi method was adopted to develop on relevant regimens and statements, along key definitions in NMDARE (disease severity, failure improve, relapse). Finally, online face-to-face meeting held reach (defined as ≥75% agreement).Corticosteroids are recommended children (pulsed IV...
To clarify whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cause encephalopathy in children and which are the most common syndromes that them what outcomes.A nationwide web-based survey among all members of Japanese Society Child Neurology to identify pediatric patients aged < 18 years who developed Japan between 1 January 2020 31 May 2022 associated with confirmed by polymerase chain reaction or antigen tests using pharyngeal swabs. Acute was defined as onset...
Sakuma H, Awaya Y, Shiomi M, Yamanouchi Takahashi Saito Sugai K, Sasaki M. Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis. Acta Neurol Scand: 2010: 121: 251–256.© 2009 The Authors Journal compilation © Blackwell Munksgaard. Objective – We conducted nationwide multicenter study in Japan to elucidate the clinical and laboratory characteristics acute (AERRPS). Materials methods Clinical features, treatment, outcome were...
<h3>Objective</h3> The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data effective therapies pediatric patients, in a reasonable timeframe, with key focus on short- and long-term safety. <h3>Methods</h3> International Pediatric Multiple Sclerosis Study Group convened meeting of experts review the advances understanding pediatric-onset multiple sclerosis (MS) advent trials population. <h3>Results</h3> In last few years, convincing...
Abstract Objective Increasing reports suggest a role for immunological mechanisms in febrile infection‐related epilepsy syndrome (FIRES). The objective of this study was to elucidate the efficacy and safety intrathecal dexamethasone therapy (IT‐DEX). Methods We assessed six pediatric patients with FIRES who were administered add‐on IT‐DEX acute (n = 5) chronic 1) phases. evaluated clinical courses prognosis. measured cytokines/chemokines cerebrospinal fluid (CSF) from at several points,...
Abstract Aim To develop standardized diagnostic criteria for ‘infection‐triggered encephalopathy syndrome (ITES)’ and five specific clinical syndromes of ITES. Method The draft definitions were based on existing criteria, standardized, discussed by a panel international experts using nominal group technique over 18 months to achieve consensus. All use the same format: (1) presence infection/fever; (2) features including encephalopathy; (3) neuroradiological magnetic resonance imaging; (4)...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sometimes triggers encephalopathy as a serious neurological complication in children. We previously reported the clinico-radiological findings of SARS-CoV-2-associated encephalopathy. The advent SARS-CoV-2 omicron variant led to marked increase pediatric patients with disease 2019 (COVID-19); however, epidemiological changes according emergence have not yet been documented. Therefore, present study investigated differences during...
Abstract The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, plays crucial roles in numerous neurological diseases. Activation of the leads to caspase‐1 dependent cleavage pro‐IL‐1β form mature IL‐1β. By acting on P2X7 purinergic receptor, extracellular ATP one major stimuli activates inflammasome. Although microglia express multiple receptors, their inflammasome‐mediated inflammation are largely unknown. We...
Febrile infection-related epilepsy syndrome (FIRES) is a type of new-onset refractory status epilepticus (NORSE) that occurs in previously healthy children. Conventional antiepileptic drugs (AEDs) often fail to control seizures, necessitating the use high-dose anesthetics, which can lead severe complications and poor outcomes. Perampanel has shown promise treatment epilepsy; however, its role FIRES remains underexplored. We report case 13-year-old boy with FIRES, was characterized by...
While advancements in the classification of acquired demyelinating syndromes have significantly benefited children with this condition, some cases present overlapping features, posing diagnostic challenges. We describe an Asian girl early childhood age acute visual loss. Examination revealed right optic neuritis, left nerve atrophy and lesions juxtacortical brain parenchyma. Anti-myelin oligodendrocyte glycoprotein antibody was elevated, while oligoclonal bands anti-aquaporin 4 were...
A 13-year-old Japanese boy was admitted to hospital with tonic-clonic seizures. Brain magnetic resonance imaging (MRI) showed diffuse swelling of the gray matter and obscured cerebral sulci in lateral part right cortex. He treated intravenous midazolam, diazepam, fosphenytoin sodium hydrate, edaravone mannitol infusion due suspicion acute encephalopathy. Five days after discharge, he noticed blurred vision his left eye. Worsening visual acuity (6/60), optic disc nerve enhancement on head MRI...
Microglia, as well other tissue-resident macrophages, arise from yolk sac progenitors. Thus, it is likely that the central nervous system environment critical for acquisition of a distinct microglial phenotype. Several microRNAs are enriched in brain play crucial roles development and may also role differentiation microglia. To track hematopoietic cells into microglia, lineage-negative bone marrow were co-cultured with astrocytes absence or presence their inhibitors. Microglia-like...
Cytokine levels have been measured in acute encephalopathy (AE) to determine its pathology or as a diagnostic biomarker distinguish it from febrile seizures (FS); however, the dynamics of cytokine level changes not yet fully captured these two neurological manifestations. Thus, we aimed explore time course serum within 72 h after onset AE and FS.We retrospectively residual samples at multiple timepoints seven children whose final diagnoses were FS.The 13 cytokines appeared increase...
Although multiple sclerosis is considered to be an autoimmune disease in the CNS, immune responses that take place CNS and lymphoid organs remain elucidated. Here, we have successfully induced various subtypes of experimental encephalitis (EAE) LEW.1AV1 rats carrying RT1av1 on Lewis background genes by immunization with recombinant rat myelin oligodendrocyte glycoprotein (MOG) solutions adjuvants. The purpose present study was analyse more detail clinical immunopathological features...