A5056959392- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Polyomavirus and related diseases
- Acute Lymphoblastic Leukemia research
- Hereditary Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Myasthenia Gravis and Thymoma
- Glycogen Storage Diseases and Myoclonus
- Neurological Disorders and Treatments
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunodeficiency and Autoimmune Disorders
- Peripheral Nerve Disorders
- Pharmacological Effects of Natural Compounds
- Infectious Encephalopathies and Encephalitis
- Syphilis Diagnosis and Treatment
- Retinal and Optic Conditions
- Plant-based Medicinal Research
- Immunotoxicology and immune responses
- Vitamin D Research Studies
- Infant Development and Preterm Care
- Urticaria and Related Conditions
Pirogov Russian National Research Medical University
2015-2025
Russian Children's Clinical Hospital
2015-2024
Ministry of Health of the Russian Federation
2017-2024
<h3>Objective</h3> The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data effective therapies pediatric patients, in a reasonable timeframe, with key focus on short- and long-term safety. <h3>Methods</h3> International Pediatric Multiple Sclerosis Study Group convened meeting of experts review the advances understanding pediatric-onset multiple sclerosis (MS) advent trials population. <h3>Results</h3> In last few years, convincing...
Introduction. In 2025, we will commemorate the 100th anniversary of first pediatric case Guillain–Barré Syndrome (GBS), initially documented by M. Monnier-Vinard. This significant milestone invites a reevaluation our contemporary understanding GBS in children. While original description was thorough, categorization has expanded over time to include wider array conditions, resulting term applied various acute demyelinating polyneuropathies. The atypical forms present notable diagnostic...
N-Hexane is a solvent widely used in manufacturing as cleaner, degreaser and component of rubber cement. Chronic exposure to
To assess the efficacy and safety of сortexin in treatment children with cerebral palsy (CP) combined epilepsy.Eighty-four patients (55 boys 29 girls), aged from 1 to 11 years, CP epilepsy received cortexin together antiepileptic drugs (AEDs). Cortexin was administered doses 5-10 mg depending on patient's age body weight intramuscularly during hospitalization.Cortexin as add-on AEDs reduced for more than two times number seizures, along improvement motor function, 31 (36.9%) patients. The...
Objective : to investigate and analyze the specific features of mental development in children with opsoclonus-myoclonus syndrome (OMS) relation number exacerbations. Patients methods . A total 19 infants (8 boys 11 girls) aged 1 year 7 months 10 years OMS were examined. The investigation included an analysis medical records, a follow-up evaluation their behavior, emotional responses, functions, interview parents. Pathopsychological neuropsychological examinations used separately for under 5...
The discovery of antibodies against aquaporin-4 (AQP4) and myelinoligodendrocyte glycoprotein (MOG) confirmed the existence two disease entities distinct from multiple sclerosis (MS) — neuromyelitis optica spectrum disorders (NMOSD) glycoprotein-associated (MOGAD). Demyelinating optic neuritis (ON) can be either idiopathic (iDON) or a manifestation MS, NMOSD (AQP4-ON) MOGAD (MOG-ON). Objective : to determine clinical features ON evaluate diagnostic value optical coherence tomography (OCT) in...
Subacute sclerosing panencephalitis (SSPE) is a rare complication caused by persistent measles infection and characterized decline in cognitive functions severe motor impairments. Since SSPE considered potentially fatal of acute typically develops young individuals especially those infected prior to the age two years old, special attention must be paid implementation vaccination programs that can prevent disease. Thus, purpose this research was present demographic clinical characteristics...
Analysis of demographic, clinical, laboratory, electrophysiological and neuroimaging data pathogenetic therapy pediatric patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
Neuromyelitis optica spectrum disorders are a group of autoimmune demyelinating diseases the central nervous system characterized by severe exacerbations with development residual neurological deficit. Anti-aquaporin-4 antibody is one key factor in diagnosing, differentiating, and prescribing pathogenetic therapy. The paper discusses tests methods detecting anti-aquaporin-4 antibodies.
Introduction Opsoclonus myoclonus syndrome (OMS) in childhood still remains unexplored from the perspective of clinical psychology. Objectives and aims The research was aimed at defining types psychological development group children with OMS. study included 18 between ages 2 years 4 months 9 OMS (8 boys, 10 girls). Methods following methods were used: analysis patient's medical record, interview parents, neurological state assessment pathopsychological assessment. Results Patients divided...
Autoimmune diseases of the central nervous system (CNS) are one most socially and economically significant problems neurology. Despite identification new nosological forms autoimmune encephalitis, creation diagnostic panels for verification autoantibodies in biological fluids, use highly effective pathogenetic therapy, number errors remains high, which poses a threat to patient’s life high risk developing severe complications. Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR...
Unique experience of high-dose chemotherapy with consequent autologous hematopoietic stem cell transplantation in children severe resistant multiple sclerosis (n=7) is shown this article. At present time there enough data on sclerosis. This method was proved to be efficient and safe immunoablative conditioning regimen. In patients included study the mean rate according Expanded Disability Status Scale 5,94±0,2 (from 3 9) points. All had disseminated demyelination loci, accumulating contrast...
Prion diseases, or transmissible spongiform encephalopathies, are a group of neurodegenerative diseases with progressive dementia and movement disorders. There three variants prion pathogenesis: direct contamination, genetic sporadic forms. The following clinical forms known: Creutzfeldt-Jakob disease (common type), variant disease, Gerstmann-Straussler-Scheinker variably protease-sensitive prionopathy, fatal insomnia familial insomnia, kuru, associated diarrhea autonomic neuropathy....
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder with unknown etiology and pathogenesis. There not enough knowledge about psychological development of children OMS.To study an influence the time disease onset children's age type course on OMS.The included 26 OMS between 1 year 7 months 13 years, 10 boys 16 girls. The following methods were used: analysis patient's records, interview parents, assessment emotional, behavioral, motion state interpersonal relations.The at...
Pediatric-onset multiple sclerosis (MS) can lead to cognitive impairment (CI). In general, in early-onset MS, there are disturbances processes, such as information processing speed, attention, and controlling functions. Also, unlike adults with children show a failure various spheres of speech activity. The age onset its duration recurrence rate affect not only the accumulation stable neurological deficit, but also state sphere. Objective : study features CI adolescents MS; assess...