Multiple sclerosis (MS) is an autoimmune disease characterized by defect in regulatory function of CD4+CD25+ T cells. We demonstrated difference proportion cells CD4+CD25+FoxP3+CD127low (Tregs) within the same patients' relapse and remission. Proportion peripheral Tregs (pTregs) dropped almost two times compare to Levels pTregs remission were lower than healthy donors. Suppressive ability was decreased MS patients compared Injections expanded ex vivo autologous (eTregs) could be helpful...

Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3 pre-mRNA subject to alternative splicing, resulting in translation multiple splice variants. We have shown that Tregs from patients with amyotrophic lateral sclerosis (ALS) reduced expression full-length (FL) FoxP3, while other truncated variants are expressed predominantly. A correlation was observed between number peripheral blood...

The maturation, development, and function of regulatory T cells (Tregs) are under the control crucial transcription factor Forkhead Box Protein 3 (FoxP3). Through alternative splicing, human FoxP3 gene produces four different splice variants: a full-length variant (FL) truncated variants with deletions each exons 2 (∆2 variant) or 7 (∆7 deletion both (∆2∆7 variant). Their involvement in biology Tregs as well their association autoimmune diseases remains to be clarified. aim this work was...

Regulatory T cells (Tregs) participate in the negative regulation of inflammatory reactions by suppressing effector cells. In a number autoimmune disorders, suppressive function and/or Tregs is compromised. The lack active functioning can be restored with adoptive transfer expanded ex vivo autologous Tregs. our study, we traced differentiation and maturation CD4+CD25+FoxP3+CD127low over 7 days cultivation from initial CD4+ under conditions. resulting cell population (eTregs) demonstrated...

Despite the wide range of clinical, instrumental and laboratory methods used in modern ophthalmology, problem diagnosing optic neuropathy identifying its etiology remains relevant. A complex multidisciplinary approach involving various specialists is required differential diagnosis immune-mediated neuritis, for example multiple sclerosis, neuromyelitis optica spectrum disorder, MOG-associated diseases. Of special interest demyelinating diseases central nervous system, hereditary neuropathies...

Optic neuritis (ON) is one of the most common neuro-ophthalmic causes vision loss worldwide. Demyelinating ON can be idiopathic or symptoms autoimmune demyelinating diseases central nervous system (CNS) such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Demographic, clinical and radiological signs in these CNS have differences. In this regard, typical atypical are currently distinguished....

In the maintenance of immunological tolerance important role belongs to recently discovered population regulatory T-cells CD4+CD25+FoxP3 +. These cells have potential in suppressing pathologic immune responses observed at various autoimmune diseases including multiple sclerosis. We shown a reduction number and functional activity T-reg peripheral blood patients with sclerosis acute stage, increase their during remission, duration relationship process degree disability contents T-reg. The...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in formation primary demyelinating lesions white and gray matter, as well diffuse axonal neuronal damage. Although there has been substantial progress drug research relapsing-remitting MS, treatment progressive forms disease, can be challenging. Diffuse compartmentalized lymphocyte macrophage infiltration CNS tissue inhibits differentiation myelinating mature oligodendrocytes, disrupting...

To assess clinical efficacy and safety of the autologous (own) regulatory T-cells (Tregs)CD4+CD25+Foxp3+CD127low isolated from blood patients with remitting-relapsing multiple sclerosis. Patients autoimmune diseases have decreased number peripheral Tregs (pTreg) impaired suppressive ability. In order to restore levels pTreg, it is possible isolate precursor cells, enter expanded ex vivo Treg cells introduce an amount as vaccine.A method expansion by 30-40 times within 5-7 days has been...

Regulatory T-cells CD4⁺CD25⁺FoxP3⁺CD127low (Tregs) play a key role in the maintenance of tolerance to auto antigens, inhibit function effector T and B lymphocytes, provide balance between regulatory arms immunity. Patients with autoimmune diseases have decreased Treg numbers impaired suppressive activity. Transformed ex vivo autologous Tregs could restore destroyed immune system. We developed method for precursor cell cultivation. Following method, we were able grown up 300-400 million cells...

The discovery of antibodies against aquaporin-4 (AQP4) and myelinoligodendrocyte glycoprotein (MOG) confirmed the existence two disease entities distinct from multiple sclerosis (MS) — neuromyelitis optica spectrum disorders (NMOSD) glycoprotein-associated (MOGAD). Demyelinating optic neuritis (ON) can be either idiopathic (iDON) or a manifestation MS, NMOSD (AQP4-ON) MOGAD (MOG-ON). Objective : to determine clinical features ON evaluate diagnostic value optical coherence tomography (OCT) in...

Aim: The current study aimed to describe various types of myelitis associated with a novel coronavirus infection [coronavirus disease 2019 (COVID-19)] as well analyze cytokine profiles and cerebrospinal fluid (CSF) parameters in affected patients compare them other immune-mediated disorders—multiple sclerosis (MS), order identify possible common pathogenetic pathways consequently treatment targets. Methods: Clinical, radiological, laboratory characteristics were studied based on patients’...

Актуальность. Демиелинизирующий оптический неврит (ОН) в рамках рассеянного склероза (РС, РС-ОН) является наиболее изученным. Открытие антител к аквапорину-4 (AQP4) и миелинолигодендроцитарному гликопротеину (MOG) определило существование двух заболеваний с фенотипами виде ОН: заболевание спектра оптиконейромиелита (ЗСОНМ, AQP-ОН) заболевание, ассоциированное антителами (МОГАЗ, MOG-ОН). Цель. Определить конечную остроту зрения (ОЗ) у пациентов демиелинизирующим ОН. Материал методы. В...

The article discusses the role of myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) in demyelinating diseases central nervous system. Clinical phenotypes syndromes associated with MOG-IgG that are currently included into neuromyelitis optica spectrum disorders (NMOSD) described. However, it has been shown encephalomyelitis (MOG-EM) certain clinical, radiological, immunological and histopathological features make possible to single out these a separate nosological form. We...

Demyelinating optic neuritis and hereditary neuropathy (HON) take a leading place among the diseases, clinical syndrome of which is bilateral with simultaneous or sequential significant decrease in visual acuity. Optic can occur at onset be one syndromes within multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOGAD). HON are group neurodegenerative most common variants Leber's (LHON), associated...

Regulatory T-cells CD4⁺CD25⁺FoxP3⁺CD127low (Tregs) play a key role in the maintenance of tolerance to auto antigens, inhibit function effector T and B lymphocytes, provide balance between regulatory arms immunity. Patients with autoimmune diseases have decreased Treg numbers impaired suppressive activity. Transformed ex vivo autologous Tregs could restore destroyed immune system. We developed method for precursor cell cultivation. Following method, we were able grown up 300-400 million cells...

<h3></h3> По мере того, как продолжается пандемия COVID-19, важным вопросом является минимизация риска для иммунокомпрометированных пациентов. Пациенты с агрессивными формами рассеянного склероза (РС) нуждаются в назначении иммуносупрессивных препаратов контроля за высокой активностью аутоиммунного процесса. В целом первые международные и национальные исследования показывают, что пожилой возраст, более высокая степень инвалидизации прогрессирующий тип течения РС напрямую связаны тяжелой...

Optic neuritis (ON) can often occur at the onset of a demyelinating autoimmune CNS disease or as one its clinical manifestations. The introduction novel laboratory techniques, technical advances in magnetic resonance imaging (MRI), electrophysiologic studies, and ocular have significantly expanded spectrum optic neuropathies. Identification different forms ON based on instrumental data lead to early diagnosis underlying neurologic disorder. According current guidelines, distinguish between...

Demyelinating diseases of the CNS are a result an autoimmune attack to myelin sheaths surrounding axons. Their structural proteins become antigenic and as result, lesions appear. The identification specific antibodies directed against components myelin, using highly specialized methods laboratory diagnostics, can significantly improve diagnostic approaches. Currently, oligodendrocyte glycoprotein antibody-associated disease (MOGAD) consists demyelinating syndromes with identified antigen....