A5079886921- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Chemotherapy-related skin toxicity
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Systemic Sclerosis and Related Diseases
- Blood disorders and treatments
- Polyomavirus and related diseases
- Neurological Complications and Syndromes
- Biomedical Research and Pathophysiology
- Multiple Sclerosis Research Studies
- Cytomegalovirus and herpesvirus research
- Neuroblastoma Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Nonmelanoma Skin Cancer Studies
- Genetic Neurodegenerative Diseases
- Renal Transplantation Outcomes and Treatments
- Oral health in cancer treatment
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders Research
Ministry of Health of the Russian Federation
2015-2023
Pirogov Russian National Research Medical University
2019-2023
Russian Children's Clinical Hospital
2015-2019
Skin damage after hematopoietic stem cell transplantation (HSCT) is common and important diagnostic therapeutic problem. The most significant causes of skin lesions in HSCT are drug toxicity, infections, manifestations acute chronic “graft versus host” disease. Each the complications can manifest various forms, as well to combine with others, exerting a negative effect on patient’s condition, severe cases posing threat life. article summarizes data etiology, features pathogenesis, clinical...
Primary immunodeficiencies (PID) include a group of congenital diseases, many which are associated with high risk developing life-threatening infectious and non-infectious complications. Many PIDs require hematopoietic stem cell transplantation (HSCT), can lead to complete cure the disease. The article presents more than 20 years experience in conducting HSCT PID Russian Children's Clinical Hospital for period from 1997 2018. 88 HSCTs were performed 80 patients (64 boys 16 girls) various...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for different spectrum of diseases. This type constantly improving, but HSCT remains risky procedure with various possible complications, the main – chronic “graft versus host” disease (cGVHD). сGVHD immune disregulation, and characterized by variety clinical manifestations that reflect multiple underlying pathophysiology mechanisms. The study cGVHD has now made great progress, there’s still lot...
The graft-versus-host disease (GvHD) is frequent complication, it occurs in 50% of patients after allogeneic hematopoietic stem cell transplantation (HSCT) and one the major causes mortality not associated with recurrence. Skin lesion symptom complex acute GvHD develops within first 100 days HSCT, complicated diagnostic therapeutic problem. Significant immunosuppressive status children during posttransplant period enhances changes course dermatoses, infections, drug toxicity. Finally, can...
CAR-Т cell therapy with the use of cytotoxic lymphocytes chimeric antigen receptors occupies an important place among modern approaches to cancer treatment. This has established itself as effective method treatment CD19+ acute lymphoblastic leukemia. Nevertheless, recurrences illness are not uncommon; solid tumors genetically engineered shows modest results and it is accompanied by high toxicity. One thing, however, certain: great potential in further improving structure functions Т help...
Background. Allogenic hematopoietic stem cell transplantation (allo-HSCT) for patients with mucopolysaccharidosis is the radical method of therapy nowadays. Myeloablative conditioning regimens allow to achieve good engraftment and do not compromise clinical status a patient. Aim – show effectiveness allo-HSCT myeloablative Hurler syndrome (HS). Patients methods . We analyzed 23 at 22 HS which were performed in 2002–2015. HSCT from unrelated donors (10/10 9/10) 18 cases. Transplant: bone...
The choice of the optimal donor in absence an HLA-compatible relative, as well analysis risks hematopoietic stem cell transplantation (HSCT), is extremely important, especially patients with non-cancerous diseases. article analyzes 99 allogeneic HSCTs from unrelated donors bone marrow department Russian Children’s Clinical Hospital. included acquired and congenital forms non-malignant a compatible relative donor, treatment, requires studying factors that influence outcome treatment this...
Relevance. Chronic granulomatous disease (CGD) belongs to the group of primary immunodeficiencies. Patients with CGD have an impaired quality life, severe infections and inflammatory organ damage. Allogeneic hematopoietic stem cell transplantation (HSCT) is effective treatment method for CGD. The authors article presented experience HSCT in patients Russian Children’s Clinical Hospital. Materials methods. 20 (19 1 repeated) during period from 2009 2020 were performed nineteen All had a long...
Autologous hematopoietic stem cell transplantation (auto-HSCT) is a standard for the treatment of oncological, hematologic, and also some immune diseases, ensuring restoration blood counts after high-dose chemotherapy. In children, success mobilization collection cells (HSCs) especially important. Mobilization schemes children are decided on an individual basis, which requires development implementation recommendations improving efficiency HSCs. include use granulocyte colony-stimulating...
Veno-occlusive liver disease (VOD), now more often referred to as “sinusoidal obstruction syndrome” (SOS), is a symptom complex that develops in the early stages after hematopoietic stem cell transplantation and some chemotherapy regimens due toxicity of number drugs used accompanied by following symptoms: hyperbilirubinemia, fluid retention, weight gain, painful hepatomegaly. According various sources, incidence SOS/VOD patients with oncohematological profile ranges from 3 15 %. At present,...
Associated hematopoietic stem cell transplantation (HSCT) or transplant-associated thrombotic microangiopathy (TA-TMA) is currently a generally recognized and severe complication of HSCT with high risk mortality. TMA characterized by microangiopathic hemolytic anemia thrombocytopenia, resulting in the accumulation platelets microvasculature, which leads to dysfunction ischemic organ. The pathogenesis TА-TMA based on endothelial damage various trigger factors (in particular, chemotherapeutic...
Relevance . Infectious septic complications caused by polyresistant gram-negative micro-organisms are a pressing issue in the treatment of patients after polychemotherapy (PCT) and hematopoietic stem cell transplantation at high risk fulminant current lethality against background hematopoesis aplasia. One therapeutic strategies antimicrobial is systematic use 0.5 % hydroxymethylquinoxaline dioxide (dioxidine) solution complex antibacterial therapy with severe infectious-septic complications....
Introduction . So far there has been no clear protocol on the treatment of bacterial infections in hematopoietic cancer patients undergoing polychemotherapy (PCT) and stem cell transplantation (HSCT). Guidelines available from antibiotic therapy panels such as EMBT, NCCN, ECIL, Sepsis-3 often fail to cover entire spectrum clinical risk factors severe complications caused specifically by multiresistant Klebsiella pneumoniae. The aim study — is showcase experience demonstration Research...
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The article presents current data on prevention of fungal infection in children the context hematopoietic stem cell transplantation (HSCT) and place voriconazole it. Own experience shows results treatment patients with malignant non-malignant diseases Department bone marrow Russian Children's Clinical Hospital. A total 161 aged 4 to 18 years who received allogeneic or autologic HSCT for period from 2012 2014 was examined. It has been shown that application prophylaxis reduces incidence...
This paper gives information on the structure of immunoglobulin molecules and functions each them, as well plasma levels immunoglobulins. It provides basic requirements for safety intravenous immunoglobulins (IVVGs) indications their use in hematology/oncology hematopoietic stem cell transplantation. Their doses, regimens, possible adverse reactions are shown a number diseases. Moreover, describes experience with 10 % IVVGs federal center brief clinical examples efficiency using these agents.
Fanconi anemia (AF) is a hereditary genetic disease characterized by developmental abnormalities, progressive bone marrow failure, hypersensitivity to alkylating agents, and tendency hematological solid tumors throughout life. The only curative option in the treatment of failure patients with AF allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are no detailed descriptions allo-HSCT Russian-language literature. On example clinical case at onset myelodysplastic syndrome,...
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