A5101429813- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Orthopedic Infections and Treatments
- Neuroendocrine Tumor Research Advances
- Patient Satisfaction in Healthcare
- Bone fractures and treatments
- Liver Disease Diagnosis and Treatment
- Healthcare Quality and Management
- Cancer, Lipids, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Medical Coding and Health Information
- Cytomegalovirus and herpesvirus research
- Celiac Disease Research and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Pleural and Pulmonary Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
- PI3K/AKT/mTOR signaling in cancer
- Parvovirus B19 Infection Studies
- Electronic Health Records Systems
- Lung Cancer Research Studies
- Abdominal Trauma and Injuries
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2019-2024
Ministry of Health of the Russian Federation
2019-2023
Pirogov Russian National Research Medical University
2022
Hematopoietic stem cell transplantation (HSCT) is a treatment method for number of severe malignant and non-tumor diseases. Autologous (auto) allogeneic (allo) HSCT improves outcomes in patients with solid hematological malignancies. The toxicity conditioning regimens before often limiting factor successful transplant outcomes. most common manifestations visceral tissue are epithelial (dermatological mucosal) toxicity, hepatotoxicity, neurotoxicity. Reducing the incidence toxic complications...
Currently, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment option for relapsed / refractory (R R) acute leukemia (AL) and high-risk AL. In this article, we present our own experience of allo-HSCT in children with R The study was approved by the Independent Ethics Committee Scientific Council N. Blokhin National Medical Research Center Oncology. Fifty-one patients AL were included study: 32 had lymphoblastic (ALL), 17 myeloid (AML) 2 biphenotypic (BL)....
The potential of big data in healthcare relies on the ability to detect patterns and turn high volumes into actionable knowledge for precision medicine decision makers. Due constantly increasing amount data, systems around world are facing challenges associated with processing analysis while keeping costs under control. There is a number examples where use already provides solutions that optimize patient care generate value institutions. However, further increase variety dynamically changing...
High-dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (auto-HSCT) is a therapeutic option that allows potentiating the antitumor effect in patients with malignant neoplasms (MNs) belonging to high-risk group. However, despite effectiveness of this method, risks developing infectious and toxic complications early late post-transplantation period are higher than associated treatment according standard protocols can significantly worsen results...
BACKGROUND: In the protocols of rapid recovery after surgery, it is recommended to avoid long-term administration and/ or high doses opioids in order reduce severity their adverse reactions postoperative period. this regard, opioid-sparing anesthesia (OSA) may become a promising approach treatment cancer patients. AIM. To evaluate effectiveness multimodal OSA scheme "dexmedetomidine+ketamine (in subanesthetic doses)+lidocaine (intravenous infusion)" pediatric oncosurgery. MATERIALS AND...
Aim. To study the level of vitamin 25(OH)D in young children with chronic viral hepatitis C (CVHC) varying degrees activity. Materials and methods. Thirty-two (1 to 3 years) were examined from February 2017 May 2023. Depending on grade increase alanine aminotransferase (ALT) aspartate (AST) respect upper limit normal, patients divided into three groups: Group 1 included 17 minimal CVH activity, 2 10 low 5 subjects moderate Laboratory tests total protein, bilirubin, direct ALT, AST, calcium,...
Aim: analysis of own experience in endoprosthesis reconstruction the knee for children and adolescents with primary bone tumors. The article reports results 65 joint oncological pathology a 5-year period (2012-2017). study was approved by Independent Ethics Committee Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology, Immunology. Evaluation functional performed using MSTS scale 3 months after operation. Postoperative complications were analyzed according to...
The national medical research centers (NMRCs) play an important role in managing the quality of healthcare system and evaluating its resources within supervised profiles Russia. lack controlling NMRCs limit possibility for improving efficiency profiles. electronic benchmarking could’ve become such a tool over organizations (MO). It would allow activities MO (for example, comparing analyzed with reference MO, or dynamics changes - historical benchmarking), finding implementing most effective...
The choice of the optimal donor in absence an HLA-compatible relative, as well analysis risks hematopoietic stem cell transplantation (HSCT), is extremely important, especially patients with non-cancerous diseases. article analyzes 99 allogeneic HSCTs from unrelated donors bone marrow department Russian Children’s Clinical Hospital. included acquired and congenital forms non-malignant a compatible relative donor, treatment, requires studying factors that influence outcome treatment this...
The article presents a generalized analysis of information on benchmarking in the healthcare system both Russian Federation and foreign countries. possibilities analysis, comparative evaluation methods used implementation functions medical organizations are shown.
Purpose of the study : to show significance ultrasound diagnostics in assessing dynamics spleen mass coefficient children various age against background a chronic form EBV virus. Materials and methods . The was performed on 146 aged 3 18 years suffering from Depending age, were divided into groups. Group 1 included 63 patients 7 years; 2 consisted 28 8 11 55 12 years. clinical, laboratory examination conducted including with further determination its (SMC). Results In acute period virus, all...
Вопросы гематологии/онкологии и иммунопатологии в педиатрии
Graft versus host” disease (GvHD) is one of the most frequent and severe complications allogeneic hematopoietic stem cell transplantation (allo-HSCT). The optimal model GvHD prophylaxis in allo-HSCT from alternative donors children currently remains actual question. Materials methods. study was approved by Independent Ethics Committee Scientific Council N.N. Blokhin National Medical Research Center Oncology, Ministry Healthcare Russian Federation. Two hundred fifty six were made during...
The objective: аnalysis of complications after endoprosthetic reconstruction in children and adolescents according to the Henderson classification failure limb salvage surgery modified by International Society Limb Salvage committee (ISOLS). Materials methods.This study evaluates rates mode failures for tumor around knee 97 patients treated from 2012 2018 D. Rogachev National Medical Research Center Pediatric Hematology, Oncology, Immunology. Results. Overall 19,6 % were identified. most...
Relevance . Autologous hematopoietic stem cell transplantation (auto-HSCT) is an integral part of the treatment patients with high-risk malignancies. However, carrying out mobilization and collection cells (HSC) for weighing up to 15 kg a complex task that requires special approach multidisciplinary interaction. The purpose study present experience collecting HSC in young children at Research Institute Pediatric Oncology Hematology Federal State Budgetary Institution N.N. Blokhin National...
Neuroblastoma (NB) is considered as a model of risk-adapted therapy for malignant neoplasms in children. The use combination prognostic factors, such age, stage the tumor process, histological variant, and molecular genetic profile tumor, makes it possible to identify three risk groups characterized by different intensity prognosis. However, stratification patients with MYCN-amplified 1 NB into certain group and, consequently, choice therapeutic tactics this vary significantly protocols...
As predicted by the International Agency for Research on Cancer, in 2025 incidence of cancer world will exceed 21 million cases, with almost 300 thousand cases being childhood cancer. To effectively prevent an increase and mortality to be able give adequate assessment epidemiological situation, healthcare authorities need reliable data burden a certain territory. Therefore, population-based registries are crucial element control planning impact activities any country world. This article...
Aim. To analyze the safety and advantages of central resection in comparison with extended hepatectomies. Methods. From June 2017 to May 2020 29 liver resections for children were performed. Central hepatic carried out 8, hepatectomies – 21 patients. Preoperative investigations, intraoperative postoperative data both groups analyzed. Results. The main indication surgery was hepatoblastoma. Future remnant volume significantly higher group ( р = 0.003). No difference median operative time...
The aim of the study was to analyze our own experience using lateral approach in knee joint arthroplasty children with oncopathology. Materials and methods research: results a retrospective nonrandomized uncontrolled single-center are analyzed, within framework which 97 endoprosthetics were performed adolescents oncological pathology over 7 years (2012–2018). Lateral used 28 patients. functional assessed MSTS rating scale 6 12 months after surgery. Postoperative complications analyzed...