A5007359539- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Iron Metabolism and Disorders
- Adrenal and Paraganglionic Tumors
- Hemoglobinopathies and Related Disorders
- Brain Metastases and Treatment
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Pneumocystis jirovecii pneumonia detection and treatment
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Advanced MRI Techniques and Applications
- Cancer therapeutics and mechanisms
- Acute Lymphoblastic Leukemia research
- Neurofibromatosis and Schwannoma Cases
- Soft tissue tumor case studies
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Renal cell carcinoma treatment
- Hematopoietic Stem Cell Transplantation
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2015-2024
Ministry of Health of the Russian Federation
2015-2024
National Medical Research Center for Hematology
2022-2023
Treatment of patients with high-risk neuroblastoma (NB) is a complex challenge, and it based on response to certain elements therapy. The development introduction new treatment approaches, such as GD2-targeted immunotherapy (IT), leads improved survival in this cohort patients. aim the study was retrospectively assess effectiveness therapy NB before IT into clinical practice. We analyzed data 151 stratified group who had received accordance modified NB2004 protocol German Society for...
Interstitial lymphocytic lung disease (ILLD), a recently recognized complication of primary immunodeficiencies (PID), is caused by immune dysregulation, abnormal bronchus-associated lymphoid tissue (BALT) hyperplasia, with subsequent progressive loss pulmonary function. Various modes standard immunosuppressive therapy for ILLD have been shown as only partially effective.To retrospectively evaluate the safety and efficacy abatacept or rituximab in treatment children PID.29 (median age 11...
Neuroblastoma (NB) is the most common extracranial solid tumor in children. The neoplasm grows from progenitor cells of sympathetic nervous system and can be detected anywhere along neurological circuit: retroperitoneally, mediastinally, cervically, pelvically. Examination children with suspected neuroblastoma comprehensive performed strict compliance a therapeutic protocol. A decision on treatment regimen made based staging risk group patient. diagnosis NB patients are fully carried out...
Aplastic anemia is a life-threatening condition characterized by the suppression of all hematopoietic lineages in bone marrow. Empty intertrabecular spaces are replaced adipose tissue. With modern MR techniques for assessing fat fraction, it has become possible to capture these changes. The fraction estimated as ratio signal intensity from sum and water signals. Aim study: assess diagnostic value marrow quantification patients aged < 18 years with aplastic anemia. study was approved...
The assessment of iron accumulation in the body is important for diagnosis overload syndrome or planning and monitoring chelation therapy. Excessive organs leads to their toxic damage dysfunction. Until recently estimation was performed either directly by liver concentration and/or indirectly measuring serum ferritin level. However, noninvasive Magnetic resonance imaging (MRI) more accurate method unlike biopsy level test. In this article, we demonstrate outlines non-invasive diagnostics MRI...
The central nervous system (CNS) involvement in patients with non-Hodgkin’s lymphomas is not uncommon, especially children mature B-cells lymphomas, unlike the primary CNS lymphoma (PCNSL). PCNSL a rare extranodal form of NHL that occurs only – brain, spinal cord, meninges, eyes, and extending beyond CNS. Its frequency adults 1–2 % 5 all tumors. Data on prevalence childhood are available, limited to some case reports. This article presents literature review about diagnosis treatment report...
the study objective was to improve quality of detection medulloblastoma metastases.Magnetic resonance imaging (MRI) spinal cord in a child with posterior cranial fossa, which performed on first day after surgery, detected contrast-positive thickenings meninges cervical, thoracic, and lumbar that might be erroneously diagnosed as metastasis. These lesions spontaneously regressed within 3 weeks, verified by control MRI.In case misinterpretation MRI picture meninges, patient is regarded having...
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Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory disease from the group of multifactorial diseases. It characterized by non-infectious recurrent bone lesions, usually manifesting in childhood. The aim this study was to analyze clinical, laboratory, radiological and histological data 33 patients (12 boys, 21 girls) with diagnosis chronic osteomyelitis. This supported Independent Ethics Committee approved Academic Council Dmitry Rogachev National Medical Research Center...
Chronic granulomatous disease is a primary immunodeficiency, characterized by violation of the oxygen-dependent mechanisms phagocytosis. Mutations in genes encoding proteins NADPH-oxidase complex lead to respiratory burst. Clinical manifestations are recurrent bacterial and fungal infections, development complications due defect autophagy, accompanied an increase level interleukin-1 inthe blood. The treatment this continuous preventive antimicrobial therapy, specific therapy for...
Despite the onset of neuroblastoma (NB) in most cases takes place at age 18 months, this solid tumor is one common malignant neoplasms neonatal period. Epidural compression (EC) as a sign distribution process into spinal channel very rare phenomenon among clinical manifestations congenital NB. Exactly rarity observed condition hardens differential diagnostics states manifested with availability neurological disorders such cuts (paralyses) during A similar situation can show pathology nervous...
The most common adrenal tumor in young children is neuroblastoma, which can be difficult to differentiate from other conditions such as nephroblastoma, hemorrhage, angiomyolipoma, myelolipoma, and adenoma. This article describes a case of teratoma, one the rarest tumors children. Initially, despite its large size, it demonstrated all radiological histological signs neuroblastoma. Teratomas are germ cell usually found gonads. Adrenal teratomas extremely rare, accounting for approximately...
To analyze the initial data on future liver remnant volume and its function evaluated by 99mTc-Bromesida hepatobiliary scintigraphy in children with tumors.Extended resections were performed 58 patients aged 2 months - 208 (median 26 months) for various neoplasms. Before hepatectomy, all underwent contrast-enhanced CT volumetry 99mTc-Bromezida subsequent quantitative assessment of accumulation remnant. All consecutive eligible extended resection retrospectively analyzed.The analysis included...
4S stage is unique and heterogeneous metastatic neuroblastoma - the most common extracranial solid tumor of childhood. Extremely important multidisciplinary approach to management this group patients, from diagnosis development a therapeutic plan scheme dynamic observation.
The purpose of work was to determine CECT characteristics primary juvenile angiofibroma the nasopharynx and skull base (JNA), as well determination paths spread for tumor, search those them, which are statistically significantly associated with surgical blood loss subsequent treatment ways model possible on their basis. Materials methods. data 60 patients aged from 8 17 years were analyzed retrospectively. All boys. median age 14 years. duration disease at time surgery 7 months. correlation...
Objective. Quantitative assessment of changes in brain myelin content after the first course chemotherapy Materials and Methods. T1 T2 maps as well water fraction (MWF) macromolecular proton (MPF) maps, reflecting content, were acquired 6 patients (mean age — 13.7 ± 2.4 years) before chemotherapy. The study was carried out using on 3T MRI scanner. Statistical data processing GraphPad Prism. Results. MPF values showed an increase thalamus white matter occipital lobes brain, while MWF...
Medulloblastoma (MB) recurrence can manifest in various clinical ways and still remains a major therapeutic challenge. As reported the international literature, high-dose chemotherapy (HDCT) with autologous hematopoietic stem cell transplantation (auto-HSCT) has low effectiveness severe toxicity patients recurrent MB. Here, we analyzed tolerability of HDCT auto-HSCT 9 pediatric adolescent MB relapses whose histological samples magnetic resonance images had been reviewed at Dmitry Rogachev...
INTRODUCTION: Extracranial neurogenic tumors in children are represented by neoplasms of the sympathetic nervous system and adrenal medulla: ganglioneuromas, ganglioneuroblastomas neuroblastomas. The main prognostic factors used to stratify patients into risk groups and, many ways, determine effectiveness treatment histological type tumor presence MYCN gene amplification. OBJECTIVE: To evaluate capabilities quantitative MRI variant predict amplification children. MATERIALS AND METHODS: We...
Objective. To determine a possible assessment of the verification genetic group medulloblastomas based on MRI imaging and quantitative indicators. Materials Methods . data 60 patients with verified molecular subgroup expression level selected genes Nano String platform were retrospectivel analyzed. Results. Based signs shape contrast intensity tumor, taking into account age patients, 76 % correctly identified by groups. Conclusion The ability to predict disease in children medulloblastoma...
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare type with uncertain clinical behavior. The commonly occurred in the head and neck region. Radical surgical resection standard treatment, which often associated high risks severe postoperative complications due to localization. Alternative methods treatment including chemotherapy/radiotherapy are used metastatic, locally advanced relapsed cases MNTI. aim this study was analyze morphological characteristics tumor, evaluate...
Hepatoblastoma (HB) is the most common primary malignant liver tumor in children. Relapses of HB are rare and make up no more than 12% cases among patients who have achieved complete response after first-line therapy. The aim study was to analyze incidence, clinical characteristics outcome relapses treated according SIOPEL protocols. This supported by Independent Ethics Committee approved Academic Council Dmitry Rogachev National Medical Research Center Pediatric Hematology, Oncology,...