A5082784367- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Chromatin Remodeling and Cancer
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Chronic Myeloid Leukemia Treatments
- Cancer therapeutics and mechanisms
- Neuroendocrine Tumor Research Advances
- Hedgehog Signaling Pathway Studies
- Chronic Lymphocytic Leukemia Research
- Ocular Oncology and Treatments
- Oral and Maxillofacial Pathology
- Melanoma and MAPK Pathways
- Cancer Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Congenital Diaphragmatic Hernia Studies
- Adrenal and Paraganglionic Tumors
- Lung Cancer Research Studies
- Meningioma and schwannoma management
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2018-2025
Institute of Medical Cell Technologies
2010-2025
Ministry of Health of the Russian Federation
2018-2024
National Medical Research Center for Hematology
2017
Regional Children's Clinical Hospital No. 1
2013-2014
Ural State Medical University
2009
The World Health Organization (WHO) Classification of Tumors Soft Tissue and Bone subdivides rhabdomyosarcomas (RMSs) into alveolar, embryonal, pleomorphic, spindle cell RMSs. Advances in molecular genetic diagnostics have made it possible to identify new RMS subgroups within traditional morphological entities. One these comprises rare tumors characterized by epithelioid morphology, a highly aggressive clinical course with pronounced tendency intraosseous growth, the presence pathognomonic...
Abstract: Nonmelanoma malignancies associated with congenital melanocytic nevi (CMN) are extremely rare, only 12 reported cases of rhabdomyosarcoma (RMS) to date. We present 2 additional RMS arising in giant CMN, immunohistochemical and molecular biologic investigations. The first case was a 32-year-old woman personal history melanoma CMN who, after successful treatment long remission, presented new 1-cm nodule within the CMN. Microscopically, atypical areas exhibited round cell/alveolar...
Acute megakaryoblastic leukemia (AMKL) is a heterogeneous form of acute myeloid (AML) and significantly more common in children than adults. In non-Down syndrome with AMKL, inv(16)(p13q24)/CBFA2T3::GLIS2 the most frequent genetic aberration. Pediatric CBFA2T3::GLIS2-positive AMKL strongly associated poor prognosis high cumulative incidence relapse. One key laboratory signs RAM immunophenotype, which includes dim to negative CD45 CD38 expression, extremely bright CD56 lack HLA-DR on leukemic...
Cell-free DNA (cfDNA) in body fluids is invaluable for cancer diagnostics. Despite the impressive potential of liquid biopsies diagnostics central nervous system (CNS) tumors, a number challenges prevent introducing this approach into routine laboratory practice. In study, we adopt protocol sensitive detection H3 K27M somatic variant cerebrospinal fluid (CSF) by using digital polymerase chain reaction (dPCR). Optimization was carried out stepwise, including preamplification target region and...
Despite the progress in understanding pathogenesis of diffuse brainstem tumors, treatment these neoplasms is usually empirical and conducted without morphological molecular verification. Liquid biopsy a minimally invasive technique providing data on tumor biology standard biopsy. This method based analysis cell-free nucleic acids (predominantly, extracellular DNA) biological fluids with detection specific mutations. wide implementation diagnosis disease monitoring extracranial malignancies,...
PURPOSE Midline low-grade gliomas (mLGGs) of early childhood have a poorer prognosis compared with tumors other localizations and in older patients. LGGs are associated aberrant activation RAS-RAF-MEK pathway, pharmacological inhibition the pathway has therapeutic promise. The aim this study was clinical molecular characterization infantile mLGGs, emphasis on efficacy targeted kinase inhibition. PATIENTS AND METHODS This enrolled 40 patients mLGG age <3 years. majority (30/40) received...
Abstract Background Detection of bone marrow (BM) involvement in patients with neuroblastoma is crucial for staging and defining prognosis. Furthermore, the persistence residual tumor cells BM associated an unfavorable outcome. Methods Expression PHOX2B , TH ELAVL4 B4GALNT1 (GD2‐synthase) was analyzed by quantitative polymerase chain reaction cell lines, control samples, samples from patients. The threshold level expression each gene established through receiver operator characteristic...
// Kseniya Sinichenkova 1 , Iliya Sidorov Nataliya Kriventsova Dmitriy Konovalov Ruslan Abasov Usman Alexander Karachunskiy Galina Novichkova Litvinov and Druy 2 Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry Healthcare Russian Federation, Moscow, Russia Institute Cell Technologies, Yekaterinburg, Correspondence to: Sinichenkova, email: ksinichenkova@gmail.com ORCID: orcid.org/0000-0002-1661-4205 Keywords: undifferentiated sarcoma; BRAF V600E...