A5027871279- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Eosinophilic Esophagitis
- Hair Growth and Disorders
- Autoimmune and Inflammatory Disorders Research
- Asthma and respiratory diseases
- Neonatal skin health care
- Pharmaceutical studies and practices
- Dermatological and Skeletal Disorders
- Connective tissue disorders research
- Systemic Sclerosis and Related Diseases
- Acne and Rosacea Treatments and Effects
- Human Health and Disease
- COVID-19 Clinical Research Studies
- Transgenic Plants and Applications
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- IL-33, ST2, and ILC Pathways
- Biotin and Related Studies
Sechenov University
2016-2025
Center for Children
2018-2025
Central State Medical Academy
2017-2025
Scientific Center of Children's Health
2016-2024
Ministry of Health of the Russian Federation
2016-2024
Health First
2022-2023
Hospital Infantil Universitario Niño Jesús
2022-2023
Fundación Instituto Valenciano de Oncología
2022-2023
Helsinki University Hospital
2022-2023
Aristotle University of Thessaloniki
2022-2023
This subgroup analysis of the ALLEGRO phase 2b/3 trial (NCT03732807) evaluated efficacy and safety ritlecitinib, an oral, selective dual JAK3/TEC family kinase inhibitor, for treatment alopecia areata (AA) in patients aged 12-17 years.In ALLEGRO-2b/3, ≥12 years with AA ≥50% scalp hair loss received once-daily ritlecitinib 50 or 30 mg (±4-week 200-mg loading dose) 10 placebo 24 weeks. In a subsequent 24-week extension period, groups continued their doses, initially assigned to switched 200/50...
Objectives This study aims to update the understanding of Alopecia Areata (AA) in Poland, Czechia, Russia, and Türkiye, focusing on disease burden, clinical management, patient journey. It seeks establish a consensus optimal management strategies for AA these regions. Methods A modified 2-round Delphi panel was conveyed with 23 Dermatologists (Russia; 4, Türkiye; 7, Poland; 6, Czechia; 6). The questionnaire consisted 61 statements 43 questions designed obtain an overall perception acceptance...
About 1% of children and adolescents worldwide are affected by plaque psoriasis.To evaluate the long-term efficacy safety ixekizumab for pediatric patients with moderate to severe psoriasis.This multicenter randomized clinical trial (IXORA-PEDS) evaluated psoriasis. Participants were aged 6 years younger than 18 years; had psoriasis, which was defined as Psoriasis Area Severity Index (PASI) 12 or higher, static Physician's Global Assessment (sPGA) score 3 psoriasis-affected body surface area...
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease with complex pathobiological mechanism. Understanding the differences in cytokine profile patients different phenotypes of can contribute to more personalized approach management children EoE. The purpose this research was identify clinical and anamnestic features fibrostenotic EoE evaluate significance biomarker levels predicting severity children. Materials methods used: single-center retrospective study performed that...
Introduction. Immune memory is a tool of the adaptive immune system that allows it responding quickly and effectively to repeated contact with an antigen. The role cell populations in recurrence progression immune-dependent diseases shown. Aim. To determine trend T-cell depending on effectiveness biological therapy (BT) children inflammatory bowel disease (IBD), multiple sclerosis (MS) psoriasis (PS). Materials methods. Four hundred fifty immunosuppressive (ISD) were examined during...
BACKGROUND: Eosinophilic esophagitis is an immune-mediated disease associated with activation of T2-inflammation in esophageal tissues. Monitoring eosinophilic activity children requires invasive diagnostic methods using general anesthesia. The study T2-inflammatory biomarkers currently not a generally accepted method, but may be informative and more accessible way to monitor over time. AIMS: Comparative assessment serum markers other T2-associated diseases determination the potential these...
Atopic dermatitis is a chronic multifactorial skin disease that common enough in childhood. The article presents the current data on epidemiology and dynamics of incidence pathological symptoms, pathogenesis basics, key factors development, shows classification disease. authors consider detail principles diagnosis peculiarities clinical aspect depending age. Algorithms therapeutic approach, as well basics an individual hypoallergenic diet are proposed. General recommendations possible...
The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning use biologics adults with psoriasis are reassuring, but data specific to children missing. Moreover, could impact course children.The aim this study was therefore assess children, and severity infection relation treatments.We set up an international registry paediatric patients. Children were included if they under 18 years age, had a...
Atopic dermatitis is one of the most common diseases (20‒40% among skin diseases) that occur in both genders worldwide and different age groups. The problem urgency caused by an increase morbidity, a chronic relapsing course often leads to decrease quality life disability, low efficiency traditional treatment methods, limited access contemporary effective targeted therapy. clinical guidelines, which aimed optimize care for patients with atopic dermatitis, contain up-to-date information on...
научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии на плод, проводимых в
Epidermal barrier dysfunction in children with atopic dermatitis can cause transcutaneous sensitization to allergens and allergic diseases. We evaluated the effectiveness of an early-intervention algorithm for treatment, utilizing pimecrolimus long-term maintenance therapy, reducing infants.This was a single-center cohort observational study that enrolled aged 1-4 months family history diseases, moderate-to-severe dermatitis, ≥ 1 investigated allergens. Patients who sought medical attention...
Abstract Atopic dermatitis is a chronic relapsing, inflammatory skin disorder associated with barrier dysfunction, the prevalence of which has increased dramatically in developing countries. In this article, we propose treatment algorithm for patients mild‐to‐moderate and severe atopic flares daily clinical practice. An international panel 15 dermatology allergy experts from eight countries was formed to develop practical dermatitis, particular focus on topical therapies. cases involving...
The article describes a clinical case of the development severe, life-threatening methemoglobinemia in patient with dystrophic form congenital epidermolysis bullosa while receiving drug containing benzocaine. current data on classification, pathogenesis, course and methods for treating this state has been presented. Many substances drugs that are methemoglobin formers widespread can cause chronic methemoglobinemia. Acute severe is accompanied by organ disorders. In some cases, it may be...
The vulnerable skin of neonates and infants is still developing anatomically functionally more susceptible to barrier disruption. current consensus paper explores challenges in caring for infants' skin, skincare use evaluates the role ceramides (CERs) containing cleansers moisturizers.A panel eight clinicians who treat developed a on new-born infant integrity CERs-containing importance. process consisted modified Delphi technique. selected information from literature searches, coupled with...
Congenital ichthyosis is a group (almost 100 clinical variants) of rare genetic skin diseases caused by pathogenic changes in more than 50 genes. Clinical features ichthyosis, regardless its genotype, are dry skin, peeling, hyperkeratosis frequently accompanied with erythroderma. These patients have extremely low quality life due to appearance, discomfort itching and functional limitations (pain during walking, impaired motor skills functions foci functionally relevant areas), as well...
The atopic dermatitis (AD) is common skin disease and has significant impact on patients their families quality of life. In recent years the term “sensitive skin" been used more frequently. It separate syndrome with subjective perception (such as burning, itching, tingling, etc.) along thickening dryness in response to environmental factors (biotic, abiotic anthropogenic) which normally do not cause such symptoms. This often associated AD. AD sensitive pathogenesis management are presented...
Pruritus is one of the main clinical manifestations atopic dermatitis, and it significantly reduces quality life patients in childhood. Scientific images on its pathophysiological basis have now undergone significant changes. The histamine exceptional role pruritus development was confounded, as well data immune system involvement maintenance given. This article presents current differential approaches to management depending etiopathogenetic characteristics. dermocosmetics restoration skin...
Psoriasis is multifactorial systemic disease characterized by excessive hyperkeratosis due to impaired keratinocytes proliferation and differentiation. This often manifests in childhood it usually associated with the development of comorbid conditions some which are combined term «psoriatic march» (obesity, metabolic syndrome, etc.). The course psoriasis related comorbidities children has several specific features that determine topicality studying all aspects clinical diagnosis prevention...
В статье представлены современные данные о патогенезе вульгарных акне (ВА), особенностях клинической картины, диагностике и терапевтической тактике у детей подростков. Приведены сведения влиянии наиболее значимых внешних внутренних факторов на патогенез риск развития ВА. На основе анализа Европейских методических рекомендаций Глобального альянса по лечению ВА сформированы соответствующие диагностические терапевтические алгоритмы ведения пациентов. Также продемонстрирована важная роль...
The recessive form of dystrophic epidermolysis bullosa (RDEB) is a debilitating disease caused by impairments in the junctions dermis and basement membrane epidermis. Mutations COL7A1 gene induce multiple abnormalities, including chronic inflammation profibrotic changes skin. However, correlations between specific mutations their phenotypic output remain largely unexplored. gene, described here, were found DEB register. Among them, two homozygous cases compound heterozygous identified. We...
ФГАУ «Национальный медицинский исследовательский центр здоровья детей»
Background . There is a need to study genetically engineered biological therapy (GEBT) survivability and identify any significant risk factors for its ineffectiveness due the increasing prevalence of psoriasis among children spreading GEBT administration. Such information has practical importance, it can be used predict treatment outcomes develop individual therapeutic approaches. Objective Our aim was in with moderate severe forms psoriasis. Methods The included data from 4-17 years old...
Atopic dermatitis is a common chronic inflammatory skin disease characterized by recurring course and progressive decrease in the quality of life. Recent studies this area demonstrate multifaceted pathogenesis atopic dermatitis. Interaction such factors as epidermal dysfunction, immune system disorders, consequences genetic mutations contributes not only to development but also its progression course. The article presents various components etiopathogenesis dermatitis, describes role lipids,...
Atopic dermatitis (AD) is the disease with chronic inflammation, epidermal barrier dysfunction and microbial dysbiosis. AD widespread, including pediatric population. The article discusses disease’s pathogenesis: skin deficiency, immunological causes of characteristics normal microbiome its disorders on both affected unaffected children AD. Main principles systemic treatment for moderate severe forms are considered. Features targeted therapy dupilumab (IL 4/IL 13 inhibitor) in discussed....