A5008482641- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Fungal Infections and Studies
- Allergic Rhinitis and Sensitization
- Spondyloarthritis Studies and Treatments
- Cytokine Signaling Pathways and Interactions
- Dermatological and Skeletal Disorders
- Contact Dermatitis and Allergies
- Acne and Rosacea Treatments and Effects
- Hair Growth and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- RNA regulation and disease
- Toxin Mechanisms and Immunotoxins
- Stress Responses and Cortisol
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Genetic and rare skin diseases.
State Research Center for Dermatovenereology and Cosmetology
2015-2024
Ministry of Health of the Russian Federation
2014-2024
Russian Academy of Sciences
2004
Background: Despite the proven efficacy and safety of biologics in treatment psoriasis (Ps), a number patients experience heterogeneity response to therapy both short-term long-term perspectives. Objective: To identify correlations between blood cytokine levels, clinical severity indices effectiveness IL12/IL23 inhibitor (ustekinumab) therapy. Methods: The study enrolled 25 with psoriasis. disease was assessed using PASI, BSA, sPGA. ustekinumab determined by percentage PASI reduction: high...
Background: The high efficacy and safety profile of IL-17 inhibitors in the treatment psoriasis have been demonstrated phase I–III studies real clinical practice. No direct comparative drugs this class registered Russia conducted. Aims: to compare therapy using netakimab secukinumab Materials methods: A non-randomized study was included 46 patients with moderate severe receiving netakimab. observation duration 25 weeks. proportions who achieved PASI100/90/75/50 values by 3, 12, 16 weeks...
Psoriasis is a common, life-long skin disease with significant negative health and societal impact. Data on rates of control treatment strategies are lacking in Central Eastern European countries. We aimed to describe the real-world severity, control, for psoriasis patients from CRYSTAL (EUPAS36459) was cross-sectional, retrospective study adults (18–75 years) Bulgaria, Estonia, Hungary, Latvia, Lithuania, Romania, Russia. enrolled moderate-to-severe receiving continuous systemic ≥24 weeks....
Background/Objectives: Psoriasis is a chronic, inflammatory, immuno-mediated cutaneous disease characterized by prominent TNFα-IL23/IL17 immune axis. In recent years, targeted therapies have become standard practice for managing moderate-to-severe psoriasis and demonstrated efficacy. At the same time, identifying factors associated with success or failure of TNFα inhibitor therapy remains one most difficult aspects in treatment. Methods: A clinical, non-randomized study was conducted to...
Atopic dermatitis is one of the most common diseases (20‒40% among skin diseases) that occur in both genders worldwide and different age groups. The problem urgency caused by an increase morbidity, a chronic relapsing course often leads to decrease quality life disability, low efficiency traditional treatment methods, limited access contemporary effective targeted therapy. clinical guidelines, which aimed optimize care for patients with atopic dermatitis, contain up-to-date information on...
Recent studies on psoriasis confirmed that interleukin-17 (IL-17) plays a crucial role in the progression of disease. Inhibition this cytokine leads to significant improvement course Russian biotechnology company BIOCAD have developed an innovative drug, monoclonal antibody against IL-17, BCD-085. The main objective phase II study was determine optimal therapeutic dose BCD-085 patients with moderate-tosevere plaque psoriasis. efficacy, safety, and pharmacokinetics drug also been...
One of the target drugs for plaque psoriasis treatment is apremilast, which a selective phosphodiesterase 4 (PDE4) inhibitor. In this study, 34 moderate-to-severe and severe patients from Russia were treated with apremilast 26 weeks. This allowed us to observe effectiveness splitting patient cohorts based on clinical outcomes, assessed using Psoriasis Area Severity Index (PASI). total, 14 (41%) indicated having an advanced outcome delta PASI 75 after treatment; 20 moderate or no effects....
Psoriasis is one of the most prevalent chronic inflammatory skin diseases. The severity its clinical manifestations can vary greatly. Objective assessment psoriasis required to select an adequate therapy. One simplest and consistent methods used determine calculate PASI (Psoriasis Area Severity Index). This index based on doctor’s determination sum indices showing intensity main symptoms psoriasis: erythema, infiltration peeling in view affected area. also be assess efficacy treatment for patients.
Goal. To study the prevalence of hereditary epidermolysis bullosa (HEB) in Russian Federation. Materials and methods. The data on number HEB patients by subjects Federation as well their age disease type were obtained based questionnaires. questionnaires sent to dermatovenerology healthcare institutions from 85 rates calculated ratio subject population size per million residents. Results. Information about 438 (210 female 228 male) aged 0-66 was collected 70 January 1, 2015. specified for...
Background. Efficacy the narrow-band UVB phototherapy in patients with atopic dermatitis varies greatly. An important condition for achieving optimal therapeutic effect is identification of factors that can impact on efficacy therapy and considering their influence when prescribing treatment.
 Aims. The present study aimed to identify which affect dermatitis
 Methods. A prospective, open-label trial was conducted evaluate safety moderate-to-severe dermatitis. All were treated four...
To study the expression of IL-17A in inflammatory infiltrating cells plaques as one key points pathological process moderate to severe psoriasis.The material obtained from 50 patients with and psoriasis was examined by an indirect immunofluorescence assay determine composition cell infiltrate type IL-17A-producing foci lesion. The markers lymphocytes (CD3), dendritic (CD11c), neutrophilic granulocytes (Mpo), mast (Trp) were used. proliferative activity basal keratinocytes (Ki-67), IL-17A,...
to define the role of neurotransmitters and their receptors in development itch maintenance a skin inflammatory response patients with psoriasis atopic dermatitis.Skin biopsy specimens from 30 dermatitis were investigated by histological, immunoperoxidase, indirect immunofluorescence assays. The investigators determined expression protein gene product 9.5 (PGP9.5), amphiregulin, semaphorin 3A, calcitonin gene-related peptide (CGRP) its receptor (CGRP-R), nerve growth factor (NGF) TrkA,...
Background: Inherited epidermolysis bullosa is a group of genetic skin disorders. In most severe forms, such as junctional and dystrophic subtypes, quality life expectancy are significantly decreased. Therapeutic approaches include wound care complication treatment.Aims: To evaluate the incidence prevalence inherited in Russian Federation, sociodemographic characterisrics provision healthcare.Methods: conduct research forms summarizing demographic, medical social information on patients were...
Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. The aim present study was to produce up-to-date information on different phototherapy approaches skin cytokines in patients with MF.A total 27 mycosis were treated phototherapy: NB-UVB (narrow-band ultraviolet B therapy) (10 patients) and PUVA (long-wavelength radiation spectrum A use skin-photosensitizing furocoumarins) therapy (17 patients). Evaluation effectiveness treatment carried out using BSA (body surface...
Mycosis fungoides is an epidermotropic primary cutaneous T-cell lymphoma, represented com-posed of small and medium-sized lymphocytes with cerebriform nuclei. Differential diagnosis lymphoma chronic autoimmune dermatoses, including psoriasis, may present significant chal-lenges in some cases. We analyzed three clinical cases mycosis fungoides, which psoriasis was initially diagnosed. Histological immunohistochemical studies a wide panel antibodies (CD4 CD8, CD2, CD5, CD7, CD3) were...
Objective — Assessment of phosphodiesterase-4 inhibitor (apremilast) therapy’s influence on skin cytokine levels in patients with moderate-to-severe and severe psoriasis. Material Methods An open, uncontrolled study was conducted. 16 plaque psoriasis (13 men, 3 women; mean ± standard deviation (SD) age 35.1±9.7 years, range 21-60) were enrolled. The Psoriasis Area Severity Index (PASI) 20.7±8.93 (range 10-47). All prescribed apremilast 30 milligrams (mg) per os (PO) Bis In Die (BID)....
Pemphigus vulgaris is a severe, socially significant autoimmune disease associated with autoantibodies to the desmoglein 3 antigen. The affects all age groups, beginning at 18 years of age; mortality rate pemphigus can reach as high 50%, depending on patient's and number other factors. There no highly selective or personalized therapy for moment. One well-known therapeutic approaches use rituximab, an anti-CD20 antibody that help achieve B cell depletion in peripheral blood. To solve problem...
Congenital epidermolysis bullosa (CEB) is an extensive group of hereditary skin diseases, the differential diagnosis which a challenge due to rarity this pathology and diversity its clinical manifestations. The determination type CEB makes it possible estimate prognosis facilitate prenatal diagnosis.to optimize morphological different types CEB.28 biopsies from 14 patients with were investigated. investigators performed routine histological examination fragments taken bullous area...
Background. Netakimab, a recombinant humanized monoclonal antibody, specifically binding to IL-17 blocks its activity resulting in plaque psoriasis signs decrease. The results of the first year BCD-085-7/PLANETA study showed high efficacy and favorable safety profile treatment patients with moderate-to-severe psoriasis.
 Aims. Efficacy assessments netakimab through 2 years Materials methods. is ongoing Randomized, Double-blind, Placebo-Controlled Phase III clinical study. In study, 213...
The paper presents an analysis of different variants acne classifications and the assessment severity, carried out by working group RODVK Committee for Classifications in Dermatovenereology. There is a division vulgaris according to age severity. Assessing severity important choosing correct prescriptions daily practice evaluation treatment outcomes. Most existing grading systems are based either on global or calculating number lesions variety anatomic locations. For clinical...
Objective: to evaluate the efficacy and safety of a selective phosphodiesterase type 4 inhibitor in patients with psoriasis psoriatic arthritis (PsA). Subjects methods. An open uncontrolled study was conducted, which enrolled 20 (12 men, 8 women); their mean age 39.2±14.3 years, duration PsA 20.2±12.2 10.4±10.2 respectively. All included had previously received phototherapy, systemic drugs (methotrexate, aromatic retinoids) an insufficient effect. Apremilast administered according standard...
Congenital epidermolysis bullosa is a clinically and genetically heterogenous group of hereditary skin diseases characterized by the formation bullae and/or erosions in response to insignificant mechanical effect. The variety severity clinical manifestations disease determine early disablement patients decrease quality life, which requires development pathogenetic etiological methods treatment. Methods gene therapy are most promising direction study, since they can affect cause congenital bullosa.
Certain level of new registered cases leprosy in a number endemic countries the world, as well growing rate transboundary migratory flows, raise issue effective diagnosis this disease with sporadic incidence leprosy, including Russian Federation. The purpose study was to develop highly sensitive PCR test for detecting genetic material Mycobacterium leprae and compare robustness sensitivity commercially available Leprosy Genesig Standard Kit (Primerdesign Ltd., UK). proposed approach uses...
Background.Psoriasis is a widespread skin disorder characterized by cytokines as the main modulators of inflammation. A promising psoriasis therapy approach targeted on cytokine networks inhibiting phosphodiesterase 4 (PDE-4). The efficacy and safety PDE-4 inhibitor apremilast in confirmed multicenter controlled studies, which, however, are accompanied reports unsuccessful cases.Aims to determine early immunological predictors for (apremilast) based lesions analyzes patients with moderate...