A5058532914- Nutrition, Genetics, and Disease
- Digestive system and related health
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Advanced Proteomics Techniques and Applications
- Birth, Development, and Health
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- PARP inhibition in cancer therapy
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Telomeres, Telomerase, and Senescence
- Psoriasis: Treatment and Pathogenesis
- Tryptophan and brain disorders
- Pharmacogenetics and Drug Metabolism
- Circular RNAs in diseases
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
Institute of Biomedical Chemistry
2018-2025
Genetic Technologies (Australia)
2024
Research Centre for Medical Genetics
2017-2023
Institute of Biomedical Science
2021
Center for Genomic Science
2021
Russian Academy of Sciences
2018
Abstract Despite of multiple systematic studies schizophrenia based on proteomics, metabolomics, and genome-wide significant loci, reconstruction underlying mechanism is still a challenging task. Combination the advanced data for quantitative association study (GWAS) can enhance current fundamental knowledge about molecular pathogenesis schizophrenia. In this study, we utilized proteomic metabolomic assay, high throughput genotyping GWAS study. We identified 20 differently expressed proteins...
Cardiovascular diseases (CVD) are the primary cause of mortality globally. A significant aspect CVD involves their association with aging and susceptibility to neonatal programming. These factors suggest that adverse conditions during development can disrupt cardiomyocyte differentiation, thereby leading heart dysfunction. This study focuses on long-term effects inflammatory oxidative stress due lactose intolerance (NLI) transcriptome phenotype. Our recent bioinformatic focused toggle genes...
Many cardiovascular diseases originate from growth retardation, inflammation, and malnutrition during early postnatal development. The nature of this phenomenon is not completely understood. Here we aimed to verify the hypothesis that systemic inflammation triggered by neonatal lactose intolerance (NLI) may exert long-term pathologic effects on cardiac developmental programs cardiomyocyte transcriptome regulation. Using rat model NLI lactase overloading with methods cytophotometry, image...
One of the target drugs for plaque psoriasis treatment is apremilast, which a selective phosphodiesterase 4 (PDE4) inhibitor. In this study, 34 moderate-to-severe and severe patients from Russia were treated with apremilast 26 weeks. This allowed us to observe effectiveness splitting patient cohorts based on clinical outcomes, assessed using Psoriasis Area Severity Index (PASI). total, 14 (41%) indicated having an advanced outcome delta PASI 75 after treatment; 20 moderate or no effects....
High temperature is a critical environmental and personal factor. Although heat shock well-studied biological phenomenon, hyperthermia response of stem cells poorly understood. Previously, we demonstrated that sublethal induced premature senescence in human endometrial mesenchymal (eMSC). This study aimed to investigate the fate eMSC-survived (SHS) with special emphasis on their genetic stability possible malignant transformation using methods classic molecular karyotyping, next-generation...
Temperature is an important exogenous factor capable of leading to irreversible processes in the vital activity cells. However, long-term effects heat shock (HS) on mesenchymal stromal cells (MSC) remain unstudied. We investigated karyotype and DNA repair drivers pathways human endometrium MSC (eMSC) survived progeny at passage 6 after sublethal stress (sublethal (SHS-SP)). G-banding revealed outbreak random instability caused by chromosome breakages aneuploidy. Molecular karyotyping...
Background COVID-19 disease has infected more than 772 million people, leading to 7 deaths. Although the severe course of can be prevented using appropriate treatments, effective interventions require a thorough research genetic factors involved in its pathogenesis. Methods We conducted genome-wide association study (GWAS) on 7,124 individuals (comprising 6,400 controls who had mild moderate and 724 cases with COVID-19). The inclusion criteria were acute respiratory distress syndrome (ARDS),...
Abstract Background Lactase persistence — the ability to digest lactose through adulthood is closely related evolutionary adaptations and has affected many populations since beginning of cattle breeding. Nevertheless, contrast initial phenotype, lactase non-persistence or adult deficiency, still affecting large numbers people worldwide. Methods We performed largest multiethnic genetic study deficiency on 24439 in Russia date. The percent each population group was estimated according local...
The proprietary protocol of human plasma samples preparation for proteomic and metabolomic assays following-up the high-resolution liquid chromatography-mass spectrometry analysis. provides support label-free quantitative measurements using UPS-2 (Universal Proteomic Standard, dynamic range) kit.
The aim of the study is to determine position genome-wide association as a method associated with risk increase breast cancer development in clinical practice. Material and methods. literature search conducted PubMed, Scopus, Cochrane Database Systematic Reviews other databases. keywords used for are cancer, (GWAS), polygenic score. depth 10 years. Results. Breast most common oncological disease women worldwide. For identification genetic variants, causing it possible use study. Furthermore,...