A5077315415- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Digestive system and related health
- Genomics and Chromatin Dynamics
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Neurobiology and Insect Physiology Research
- Medical and Biological Sciences
- Inflammasome and immune disorders
- Genetics and Neurodevelopmental Disorders
- interferon and immune responses
- GDF15 and Related Biomarkers
- Cardiovascular Function and Risk Factors
- PARP inhibition in cancer therapy
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Plant Molecular Biology Research
- Liver Disease Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Mental Health Research Topics
- Helicobacter pylori-related gastroenterology studies
- Developmental Biology and Gene Regulation
Institute of Gene Biology
2018-2022
We present the results of depression Genome-wide association studies study performed on a cohort Russian-descent individuals, which identified novel at chromosome 7q21 locus. Gene prioritization analysis based already known risk genes indicated MAGI2 (S-SCAM) as most probable gene from locus and potential susceptibility for disease. Brain gut expression patterns were main features highlighting functional relatedness to previously genes. Local genetic covariance analysis, expression, provided...
The ability to digest lactose in adulthood is caused by a genetic mutation that emerged following the domestication of cattle approximately 10 000 years ago. However, many adults retain primary lactase deficiency - ancestral phenotype characterized decline enzyme activity after weaning. While global prevalence this condition well-documented, reliable large-scale population data for Russia have been lacking so far. Microarray genotyping markers now enables high-quality, up-to-date research...
Abstract For many years it was believed that promoter-proximal RNA-polymerase II (Pol II) pausing manages the transcription of genes in Drosophila development by controlling spatiotemporal properties their activation and repression. But exact proteins cooperate to stall Pol regions developmental are still largely unknown. The current work describes molecular mechanism employed Negative ELongation Factor (NELF) control pause at whose is induced 20-hydroxyecdysone (20E). According our data,...
BACKGROUND: Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has transdiagnostic nature and one of the key symptoms mood disorders, schizophrenia, addictions, somatic conditions. AIM: To evaluate genetic architecture anhedonia its overlap with other mental disorders METHODS: We performed genome-wide association study on sample 4,520 individuals from Russian non-clinical population. Using available summary statistics, we...
Background COVID-19 disease has infected more than 772 million people, leading to 7 deaths. Although the severe course of can be prevented using appropriate treatments, effective interventions require a thorough research genetic factors involved in its pathogenesis. Methods We conducted genome-wide association study (GWAS) on 7,124 individuals (comprising 6,400 controls who had mild moderate and 724 cases with COVID-19). The inclusion criteria were acute respiratory distress syndrome (ARDS),...
To conduct an exploratory Mendelian randomization analysis of the causal relationships anhedonia with a wide range psychiatric and somatic phenotypes based on genetic data participants in population study.This cross-sectional study included 4520 participants, which 50.4% (n=2280) were female. The mean age was 36.8 (S.D.=9.8) years. Participants pheno-nailed DSM-5 criteria for framework depression. An episode exceeding 2 weeks during life reported by 57.6% (n=2604) participants. A genome-wide...
According to previous studies, during Drosophila embryogenesis, the recruitment of RNA polymerase II precedes active gene transcription. This work is aimed at exploring whether this mechanism used metamorphosis. In addition, composition “paused” complexes associated with promoters different developmental stages are described in detail. For purpose, we performed ChIP-Seq analysis using antibodies for various modifications (total, Pol CTD Ser5P, and Ser2P) as well subunits NELF, DSIF, PAF...
Abstract Background Lactase persistence — the ability to digest lactose through adulthood is closely related evolutionary adaptations and has affected many populations since beginning of cattle breeding. Nevertheless, contrast initial phenotype, lactase non-persistence or adult deficiency, still affecting large numbers people worldwide. Methods We performed largest multiethnic genetic study deficiency on 24439 in Russia date. The percent each population group was estimated according local...
Adult lactase deficiency – the inability to effectively digest lactose in adulthood causes digestive discomfort and may be associated with elimination of a whole category dairy products from diet. The objective study was assess prevalence gene for sample 24 thousand people living Russia. It turned out that among studied population groups, frequency occurrence GG genotype rs4988235 higher than average European populations. In particular, group Eastern Slavs 42.8% (95% CI: 42.1–43.4%)....