A5046826910- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Cultural Differences and Values
- Hedgehog Signaling Pathway Studies
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Cardiac Health and Mental Health
- Genetic and phenotypic traits in livestock
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Healthcare Systems and Public Health
- Digestive system and related health
- Forensic and Genetic Research
- Cardiovascular Health and Risk Factors
- Diet, Metabolism, and Disease
ITMO University
2022-2024
Federal Almazov North-West Medical Research Centre
2021-2024
Broad Institute
2022-2024
Abstract The population of Russia consists more than 150 local ethnicities. ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the uniquely positioned investigate shared properties inherited disease risks between European Asian ancestries. We present analysis genetic phenotypic data a cohort 4,145 individuals collected in three metro areas western Russia. show presence multiple admixed ancestry clusters spanning primarily high identity-by-descent sharing...
We present the results of depression Genome-wide association studies study performed on a cohort Russian-descent individuals, which identified novel at chromosome 7q21 locus. Gene prioritization analysis based already known risk genes indicated MAGI2 (S-SCAM) as most probable gene from locus and potential susceptibility for disease. Brain gut expression patterns were main features highlighting functional relatedness to previously genes. Local genetic covariance analysis, expression, provided...
Abstract The population of Russia consists more than 150 local ethnicities. ethnic diversity and geographic origins, which extend from eastern Europe to Asia, make the uniquely positioned investigate shared properties inherited disease risks between European Asian We present analysis genetic phenotypic data a cohort 4,145 individuals collected in three metro areas western Russia. show presence multiple admixed ancestry clusters spanning primarily high identity-by-descent sharing with Finnish...
Numerous studies demonstrated the lack of transferability polygenic score (PGS) models across populations and problem arising from unequal presentation ancestries genetic studies. However, even within European ancestry there are ethnic groups that rarely presented in For instance, Russians, being one largest, diverse, yet understudied group Europe. In this study, we evaluated reliability genotype imputation for Russian cohort by testing several commonly used reference panels (e.g. HRC,...
Age-related changes in the vascular system play an important role biological age and lifespan of a person maybe affected from early onward. One indicators is arterial wall stiffness its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined sample 305 Leningrad Siege survivors to assess how hunger stressful conditions during fetal development childhood state cardiovascular at later what factors may neutralize negative impact sustained childhood. Here, we presented...
Abstract Introduction Cardiovascular diseases (CVD) are the most serious public health problem, remaining leading cause of death in adult population. A great number CVD risk scales successfully used clinics, yet they tuned to work best for patients older age and often population specific. Methods We data from a longitudinal epidemiologic study 4,750 individuals aged 25–64 years European part Russia recruited 2012–2013 predict 10-year cardiovascular events Russian evaluate performance common...