A5020905652- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Pediatric health and respiratory diseases
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Effects of Radiation Exposure
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Endometrial and Cervical Cancer Treatments
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Discourse Analysis and Cultural Communication
- Chemical Reactions and Isotopes
- Legal and Policy Issues
- Digital Transformation in Law
- Lymphoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
Tomsk National Research Medical Center
2019-2025
Russian Academy of Sciences
2020-2024
Siberian State Medical University
2022
Scientific Center of Children's Health
2021
Tomsk Cancer Research Institute
2004-2016
Academy of Medical Sciences
2014-2016
Lung cancer is the leading cause of morbidity and mortality in world each year. Despite radical surgical treatment, 5-year survival rate at stages I-II remains unsatisfactory. Objective. To assess whether an overall personalized approach to chemotherapy selection preoperative regimen has impact on relapse-free outcomes. Material Methods. The results use neoadjuvant (NACT) both Russia around were studied analyzed. experience prescribing NACT shown a study conducted conditions Oncology...
Recurrences occur in 30 % of lung cancer patients after radical therapy; however, known prognostic factors are not always effective. In this study, we investigated whether the frequency squamous non-small cell (NSCLC) recurrence depends on presence reactive lesions tumor-adjacent bronchial epithelium. Specimens adjacent tissue from 104 with NSCLC were used for determination basal hyperplasia (BCH) and metaplasia (SM) analysis expression Ki-67, p53, Bcl-2, CD138. We found that was observed...
The study assessed the possibility of dividing patients into groups based on assessment morphological changes in epithelium small-caliber bronchi located near primary tumor order to predict high and low risks distant metastasis non-small cell lung cancer. In 171 with cancer (T1-4N0-3M0) taken at a distance 3-5 cm from tumor, various variants bronchial (basal hyperplasia (BCH), squamous metaplasia (SM), dysplasia (D)) were assessed. Long-term results treatment, namely, metastasis, after 2 5...
Basal cell hyperplasia (BCH) and squamous metaplasia (SM) in the small bronchi distant from tumor is associated with a high risk of non-small lung cancer (NSCLC) recurrence. Here, we assessed whether neoadjuvant chemotherapy (NAC), intraoperative radiotherapy (IORT), or adjuvant (AC) effective to prevent recurrence NSCLC patients (n=171) different premalignant lesions bronchi.BCH, SM, dysplasia (D) were identified samples tissue tumor. treated by surgery, combinations NAC IORT, AC.Based on...
The premalignant process preceding squamous cell lung cancer is not inevitable; it can stop at any of the bronchial lesions: basal hyperplasia (BCH), metaplasia (SM), and dysplasia then progress or regress. At present, mechanisms underlying progression lesions remain undefined. Previously, we hypothesized that presented individually combined with each other in bronchi patients mirror different “scenarios” process: individual BCH—the stoppage stage hyperplasia, BCH plus SM—the to metaplasia,...
The objective of the present study was to determine incidence dysplastic pre-neoplastic alterations in patients presenting with papillomatosis. results clinical, endoscopic, and morphological examination 42 laryngeal papillomas made it possible diagnose grade II-III cancer 7 (16.7%) patients. Half them exhibited changes mucosa. following criteria for formation risk groups, besides epithelial dysplasia, were identified: long (over 12 months) history papillomatosis, human papilloma virus...
The data on modern views the problem of pre-cancerous changes (epithelial hyperplasia, squamous metaplasia, preneoplasia (dysplasia I) and neoplasia II-III) when cell cancer adenocarcinoma lung are summarizes in present review. Atypical adenomatous which is considered precancerous process for lung, due to rare occurrence review not considered. attention focused classification morphological characteristics respiratory epithelium. analysis frequency reversibility preand neoplastic bronchial We...
Surgery is the standard of care for non-small cell lung cancer (NSCLC). The overall survival rates especially in patients with locally advanced are low. resistance cells to chemotherapeutic drugs reduces efficacy treatment. Special attention paid feasibility assessing tumor sensitivity certain chemotherapy drugs. Currently, most studied predictors monoresistance and multidrug genes, such as ABCC5, RRM1, ERCC1, BRCA1, TOP1, TOP2a, TUBB3 TYMS. aim study was analyze outcomes combined modality...
The treatment of non-small-cell lung cancer (NSCLC) continues to be a pressing issue. It is therefore necessary advance and put into practice the methods that will improve patients survival. aim study was estimate available information on application intraoperative radiation therapy (IORT) in combined with NSCLC. plans, safety tolerability method were evaluated. From data analysis it became clear IORT topical for operable non-small cell (NSCLC). new technology has proved its effectiveness...
Background . Despite advances in surgical and therapy techniques, non-small cell lung cancer (NSCLC) is one of the most common cancers leading cause cancer-related death. Therefore, it increasingly important to search for markers that predict risk tumor progression. The study morphology epithelium bronchi different calibers has great potential solving this problem. aim was comparatively evaluate characteristics frequency occurrence various combinations morphological changes large small...
The aim of the study: to examine relationship between morphological diversity non-small cell lung cancer and frequency lymph node metastasis in groups patients with different epithelial conditions bronchi adjacent tumor. Material methods. Surgical specimens from 90 cancer, who were treated Thoracoabdominal Department Of Research Institute Oncology Tomsk National Medical Center period 2009 2017 studied. histological type was determined according classification (2020). Lepidic, acinar,...
Background . To select the optimal treatment for non-small cell lung cancer (NSCLC), it is important to predict risk of distant metastasis and effectiveness therapy. The effect neoadjuvant chemotherapy (NAC) on remains poorly understood. In this study we evaluated feasibility predicting various options pre- intraoperative therapy in NSCLC patients with high low metastasis, divided based assessment morphological changes epithelium small bronchi located near primary tumor. Material Methods...
The purpose of the study: to evaluate effectiveness postoperative management bronchial stump in lung cancer patients. material and methods. Forty-four patients with stage III underwent endoscopic examination tree 3, 6, 9 12 months after surgery. EVIS EXERAII LUCERA videoendoscopic complexes consistent use white light mode, autofluorescence narrow- spectrum mode were used. Endoscopic results compared morphological findings. Results. X-ray chest was negative for tumor recurrence 3 (6.8 %)...