A5017325034- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- DNA Repair Mechanisms
- Effects of Radiation Exposure
- BRCA gene mutations in cancer
- Drug Transport and Resistance Mechanisms
- Advanced Breast Cancer Therapies
- Glutathione Transferases and Polymorphisms
- Radiopharmaceutical Chemistry and Applications
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Endometrial and Cervical Cancer Treatments
- Genomic variations and chromosomal abnormalities
- Carcinogens and Genotoxicity Assessment
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Tomsk National Research Medical Center
2016-2025
Russian Academy of Sciences
2012-2025
National Research Tomsk State University
2016-2025
Siberian State Medical University
2022-2025
Tomsk Polytechnic University
2024
Federal Medical-Biological Agency
2010-2024
Tomsk Cancer Research Institute
2010-2021
Russian University of Cooperation
2019
Cancer Research Institute
2016
Research Institute of Medical Genetics of Russian Academy of Medical Sciences
2014
In breast cancer, the tumor microenvironment plays a critical role in progression and responses to therapy. Tumor-associated macrophages (TAMs) are major innate immune cells that regulate intratumoral immunity angiogenesis by secretion of cytokines, growth factors as well chitinase-like proteins (CLPs), combine properties cytokines factors. YKL-39 is protein found human absent rodents, its expression TAMs cancer was not studied date. Here for first time we demonstrate expressed on TAMs,...
Abstract To date, numerous mechanisms have been identified in which one cell engulfs another, resulting the creation of ‘cell-in-cell’ (CIC) structures, subsequently cause death. One formation these structures is entosis, presumably associated with possible carcinogenesis and tumour progression. The peculiarity process that entotic cells themselves actively invade host cell, afterwards several variants fate. Entotic formations are where engulfed by another creating a cell-in-cell structure....
// Nikolai V. Litviakov 1, 2 , Nadezhda Cherdyntseva 2, 3 Matvey M. Tsyganov Elena Slonimskaya 4 Marina K. Ibragimova 1 Polina Kazantseva Julia Kzhyshkowska 5 Eugeniy L. Choinzonov 6 Laboratory of Oncovirology, Tomsk Cancer Research Institute, Tomsk, Russian Federation Translational Cell and Molecular Biomedicine, National State University, Oncology Immunology, Department General Oncology, Innate Immunity Tolerance, Institute Transfusion Medicine Medical Faculty Mannheim, University...
In this study, the influence of intratumoral morphological heterogeneity breast cancer on neoadjuvant chemotherapy (NAC) efficiency was investigated. particular, we analysed association NAC response and pre- post-NAC expression main multidrug resistance (MDR) genes - ABCB1, ABCC1, ABCC5, ABCG1 ABCG2, with presence different structures in tumors. addition, MDR investigated their microenvironment by comparing probes obtained using laser microdissection. The results study showed that tumors...
Aim: To provide a breast cancer (BC) methylotype classification by genome-wide CpG islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation sequencing methylation method was used to profile of 110 BC samples and 6 normal samples. Intrinsic subtypes were elicited unsupervised hierarchical cluster analysis, cluster-specific differentially methylated genes identified. Results conclusion: Overall, six distinct methylotypes cell lines constitute separate group extremely...
We propose an original strategy for metastasis prevention using a combination of three microRNAs that blocks the dedifferentiation cancer cells in metastatic niche owing to downregulation stemness genes. Transcriptome microarray analysis was applied identify effects mixture on pattern differentially expressed genes human breast cell lines. Treatment differentiated CD44– with microRNA inhibited their ability form mammospheres vitro. The these encapsulated into lipid nanoparticles prevented...
Breast cancer (BC) demonstrates considerable intratumoral morphological heterogeneity. The aim of this work was to evaluate the relationship among different structures, rate metastasis, and efficacy neoadjuvant chemotherapy (NAC) in NAC-treated (n = 427) NAC-nave 249) BC patients. We also studied involvement an epithelial-mesenchymal transition (EMT) development heterogeneity BC. found a significant association between metastasis response NAC, which, most cases, correlated with presence...
Abstract Despite the advantages of neoadjuvant chemotherapy (NACT), associated toxicity is a serious complication that renders monitoring patients’ response to NACT highly important. Thus, prediction tumor treatment imperative avoid exposure potential non-responders deleterious complications. We have performed genome-wide analysis DNA methylation by XmaI-RRBS and selected CpG dinucleotides differential which discriminates luminal B breast cancer samples with different sensitivity NACT. With...
// Nikolai Litviakov 1 , 2 Marina Ibragimova Matvey Tsyganov Polina Kazantseva 3 Irina Deryusheva Alina Pevzner Artem Doroshenko Eugeny Garbukov Natalia Tarabanovskaya and Elena Slonimskaya 4 Laboratory of Oncovirology, Cancer Research Institute Tomsk NRMC, Tomsk, Russia Biological National State University, Department General Oncology, Faculty Medicine, Saint-Petersburg Saint-Petersburg, Correspondence to: Litviakov, email: nvlitv72@yandex.ru Keywords: stemness genes; cancer stem cells;...
Lung cancer is the leading cause of morbidity and mortality in world each year. Despite radical surgical treatment, 5-year survival rate at stages I-II remains unsatisfactory. Objective. To assess whether an overall personalized approach to chemotherapy selection preoperative regimen has impact on relapse-free outcomes. Material Methods. The results use neoadjuvant (NACT) both Russia around were studied analyzed. experience prescribing NACT shown a study conducted conditions Oncology...
This review focuses on the role of probiotics as alternative prevention and treatment cancer. In this regard, we discuss cancer biotherapeutic drugs including live or dead their metabolites, such short chain fatty acids, inhibitory compounds protein, polysaccharide, nucleic acid ferrichrome in vitro , vivo clinical studies. We also summarize available data relationship between development cervical, breast colorectal cancers, microbiome, well about potential an approach to treatment. Material...
Aim : to systematise the data of available studies related association papillomavirus infection with oesophageal squamous cell cancer. Methods . A literature search was conducted in PubMed and Google Scholar databases. All full-text articles from 1995 2023 were included. The language not a barrier inclusion this meta-analysis. total 130 sources analysed. meta-analysis based on 17 case-control studies, which together account for 1912 tumour tissue samples 2206 control normal tissue. Key...
Introduction. Evaluation of when and how to include taxanes in preoperative chemotherapy is becoming more important the era molecular genetic approaches allow develop biologically targeted therapeutic medications select patients who can benefit from certain cytotoxic agents. Aim. To analyze use CNA landscape (CNA – copy number aberration) luminal B HER2-negative (HER2 human epidermal growth factor receptor type 2) breast cancer during taxane-containing neoadjuvant (NCT) for identification...
Invasive ductal carcinoma (IDC) not otherwise specified (NOS), the most common type of breast cancer, demonstrates great intratumoral morphological heterogeneity, which encompasses presence different types structures—tubular, trabecular, solid, and alveolar structures discrete groups tumor cells, origins remain unclear at present. In this study 162 IDC NOS patients, we investigated whether distribution is related to basic clinicopathological parameters NOS. Our results showed that in...