A5010914920- Dermatology and Skin Diseases
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- Neuroscience of respiration and sleep
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Neuroscience and Neuropharmacology Research
- Allergic Rhinitis and Sensitization
- Olfactory and Sensory Function Studies
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- Regulation of Appetite and Obesity
- Wound Healing and Treatments
- Contact Dermatitis and Allergies
- Mast cells and histamine
- Sleep and Wakefulness Research
- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infant Health and Development
- Advancements in Transdermal Drug Delivery
- Burn Injury Management and Outcomes
- Eicosanoids and Hypertension Pharmacology
- DNA Repair Mechanisms
Wright State University
2016-2025
Dayton VA Medical Center
2016-2025
University Hospitals of Cleveland
2024
The Ohio State University
2012-2022
Pfizer (United Kingdom)
2022
Sanofi (Mexico)
2022
Regeneron (United States)
2022
Estée Lauder (United States)
2022
Bristol-Myers Squibb (Germany)
2022
Janssen (Belgium)
2022
Abstract Atopic dermatitis (AD) and psoriasis are the two most common chronic skin diseases. However patients with AD, but not psoriasis, suffer from frequent infections. To understand molecular basis for this phenomenon, biopsies AD were analyzed using GeneChip microarrays. The expression of innate immune response genes, human β defensin (HBD)-2, IL-8, inducible NO synthetase (iNOS) was found to be decreased in as compared (HBD-2, p = 0.00021; 0.044; iNOS, 0.016). Decreased novel...
Abstract Projections to the trigeminal, facial, ambiguus, and hypoglossal motor nuclei were determined by using horseradish peroxidase histochemistry. Most of afferent projections these from brain‐stem reticular formation, frequently in areas adjacent other synergetic nuclei. The formation lateral nucleus structures surrounding trigeminal projected each brainstem involved oral‐facial function. Afferent also organized along ros‐trocaudal axis. Within most originated rostral majority neurons...
Journal Article A metric for the breadth of tuning gustatory neurons Get access David V. Smith, Smith Department Psychology, University WyomingLaramie, Wyoming 82071, USA Search other works by this author on: Oxford Academic PubMed Google Scholar Joseph B. Travers Chemical Senses, Volume 4, Issue 3, September 1979, Pages 215–229, https://doi.org/10.1093/chemse/4.3.215 Published: 01 1979 history Received: March Revision received: May Accepted: July
Recent studies have suggested that T cells play a critical role in the pathogenesis of psoriasis. Guttate psoriasis is well-defined form frequently associated with streptococcal throat infection. This study tested hypothesis acute guttate skin lesions may be activated by superantigens. Peripheral blood as well lesional and perilesional biopsies were analyzed for cell receptor V beta repertoire using monoclonal antibodies against 10 different families. Skin from all patients psoriasis, but...
During dermal injury and the associated trauma a number of compounds are released that can mediate inflammatory response. Determining cellular mechanisms initiate responses to acute keratinocyte damage is important for understanding regulation epidermal inflammation. The recently cloned vanilloid receptor-1 (VR1) polymodal receptor, responding thermal, pH, or vanilloids such as capsaicin stimulation. Although VR1 has been localized only on sensory neurons within central nervous system,...
IL-4 promotes the development of Th2 cells and allergic inflammation. In atopic dermatitis lesions, decreases expression multiple genes associated with innate defense, including in epidermal differentiation complex (EDC) that regulate barrier function. However, it is not clear whether also contributes to homeostatic control EDC genes. this report, we demonstrate function increased absence endogenous IL-4. Mice express a constitutively active Stat6 (Stat6VT) are prone skin inflammation have...
Previous behavior studies (Grill & Norgren, 1978) demonstrated that gustatory stimuli produce stereotyped orofacial movements constitute the observable concomitants of ingestion and rejection. For further clarification relation between these (the buccal phase ingestion) act swallowing pharyngeal phase), electromyographic responses to intraoral sapid stimulation were recorded from a subset muscles in freely moving chronic preparation. Activity jaw opening muscle (anterior digastric), facial...
Prevalence of obesity among infants and children below 5 years age is rising dramatically, early childhood a forerunner obesity-associated diseases in adulthood. Childhood hence one the most serious public health challenges today. Here, we have identified mother-to-child lipid signaling that protects from obesity. We found breast milk-specific species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent infant formula adult-type diets, maintain beige adipose tissue (BeAT)...
Neurofibromatosis type 1 (NF1) is a common autosomal-dominant disorder characterized by cutaneous neurofibromas infiltrated with large numbers of mast cells, melanocyte hyperplasia, and predisposition to develop malignant neoplasms. NF1 encodes GTPase activating protein (GAP) for Ras. Consistent Knudson's “two hit” model tumor suppressor genes, leukemias solid tumors in patients frequently demonstrate somatic loss the normal allele. However, phenotypic biochemical consequences heterozygous...
Neurofibromas are common tumors found in neurofibromatosis type 1 (NF1) patients. These complex composed of Schwann cells, mast fibroblasts and perineurial cells embedded collagen that provide a lattice for tumor invasion. Genetic studies demonstrate neurofibromas, nullizygous loss Nf1 haploinsufficiency non-neuronal required tumorigenesis. Fibroblasts major cellular constituent neurofibromas source constitutes ∼50% the dry weight tumor. Here, we show two prevalent heterozygous interact...
Mutations in the NF1 tumor suppressor gene cause neurofibromatosis type I (NF1), a disease characterized by formation of cutaneous neurofibromas infiltrated with high density degranulating mast cells. A hallmark cell lines generated from patients or Nf1-deficient mice is their propensity to hyperproliferate. Neurofibromin, protein encoded NF1, negatively regulates p21ras activity accelerating conversion Ras-GTP Ras-GDP. However, identification alterations specific effector pathways that...
To cope with the frequent exposure to carcinogenic UV B (UVB) wavelengths found in sunlight, keratinocytes have acquired extensive protective measures handle UVB-induced DNA damage. Recent vitro and epidemiological data suggest one these mechanisms is dependent on functional status of insulin-like growth factor-1 receptor (IGF-1R) signaling network keratinocytes. During normal UVB response, ligand-activated IGF-1Rs protect from apoptosis; however, as a consequence, fail proliferate. This...
Oculocerebral renal syndrome of Lowe (OCRL or syndrome), a severe X-linked congenital disorder characterized by cataracts and glaucoma, mental retardation kidney dysfunction, is caused mutations in the OCRL gene. phosphoinositide 5-phosphatase that interacts with small GTPases involved intracellular trafficking. Despite extensive studies, it unclear how result myriad phenotypes found syndrome. Our results show localizes to primary cilium retinal pigment epithelial cells, fibroblasts tubular...
A complete carcinogen, ultraviolet B (UVB) radiation (290–320 nm), is the major cause of skin cancer. UVB-induced systemic immunosuppression that contributes to photocarcinogenesis due glycerophosphocholine-derived lipid mediator platelet-activating factor (PAF). question in photobiology how UVB radiation, which only absorbs appreciably epidermal layers skin, can generate effects. exposure and PAF receptor (PAFR) activation keratinocytes induce release large numbers microvesicle particles...