A5005573201- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Genetic and rare skin diseases.
- Axon Guidance and Neuronal Signaling
- Dermatologic Treatments and Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hair Growth and Disorders
- Food Allergy and Anaphylaxis Research
- Circadian rhythm and melatonin
- Toxin Mechanisms and Immunotoxins
- Histiocytic Disorders and Treatments
- Mast cells and histamine
- Nail Diseases and Treatments
- melanin and skin pigmentation
- Advancements in Transdermal Drug Delivery
- RNA regulation and disease
- Contact Dermatitis and Allergies
- Cutaneous Melanoma Detection and Management
- Spondyloarthritis Studies and Treatments
State Research Center for Dermatovenereology and Cosmetology
2015-2024
Ministry of Health of the Russian Federation
2013-2024
Background: Ultraviolet irradiation of the skin can activate cytoplasmic aryl hydrocarbon receptor AhR, which, in combination with its nuclear translocator ARNT binds to promoter FLG gene encoding filaggrin, a protective barrier protein. This suggests that therapeutic effect phototherapy may be due not only immunosuppressive effect, but also stimulation filaggrin production. Aims: evaluate ultraviolet used for various methods on expression levels FLG, AHR and genes patients atopic...
Atopic dermatitis is one of the most common diseases (20‒40% among skin diseases) that occur in both genders worldwide and different age groups. The problem urgency caused by an increase morbidity, a chronic relapsing course often leads to decrease quality life disability, low efficiency traditional treatment methods, limited access contemporary effective targeted therapy. clinical guidelines, which aimed optimize care for patients with atopic dermatitis, contain up-to-date information on...
Psoriasis is one of the most prevalent chronic inflammatory skin diseases. The severity its clinical manifestations can vary greatly. Objective assessment psoriasis required to select an adequate therapy. One simplest and consistent methods used determine calculate PASI (Psoriasis Area Severity Index). This index based on doctor’s determination sum indices showing intensity main symptoms psoriasis: erythema, infiltration peeling in view affected area. also be assess efficacy treatment for patients.
Goal. To study the prevalence of hereditary epidermolysis bullosa (HEB) in Russian Federation. Materials and methods. The data on number HEB patients by subjects Federation as well their age disease type were obtained based questionnaires. questionnaires sent to dermatovenerology healthcare institutions from 85 rates calculated ratio subject population size per million residents. Results. Information about 438 (210 female 228 male) aged 0-66 was collected 70 January 1, 2015. specified for...
Background. Efficacy the narrow-band UVB phototherapy in patients with atopic dermatitis varies greatly. An important condition for achieving optimal therapeutic effect is identification of factors that can impact on efficacy therapy and considering their influence when prescribing treatment.
 Aims. The present study aimed to identify which affect dermatitis
 Methods. A prospective, open-label trial was conducted evaluate safety moderate-to-severe dermatitis. All were treated four...
to define the role of neurotransmitters and their receptors in development itch maintenance a skin inflammatory response patients with psoriasis atopic dermatitis.Skin biopsy specimens from 30 dermatitis were investigated by histological, immunoperoxidase, indirect immunofluorescence assays. The investigators determined expression protein gene product 9.5 (PGP9.5), amphiregulin, semaphorin 3A, calcitonin gene-related peptide (CGRP) its receptor (CGRP-R), nerve growth factor (NGF) TrkA,...
Background: Inherited epidermolysis bullosa is a group of genetic skin disorders. In most severe forms, such as junctional and dystrophic subtypes, quality life expectancy are significantly decreased. Therapeutic approaches include wound care complication treatment.Aims: To evaluate the incidence prevalence inherited in Russian Federation, sociodemographic characterisrics provision healthcare.Methods: conduct research forms summarizing demographic, medical social information on patients were...
The goals of the topical treatment patients suffering from atopic dermatitis are suppression inflammatory reaction in skin, elimination itching, and recovery damaged protective lipid barrier epidermis. In this connection, glucocorticosteroids skin moisturizers used therapy dermatitis. Methylprednisolone aceponate (MPA, Advantan) being a glucocorticosteroid is characterized by high efficacy safety. MPA marked fast development therapeutic effect. This drug can be for children older than 4...
The article describes high incidence and morbidity rate of psoriasis, substantial reduction in the life quality psychosocial disadaptation patients, presents certain particular features psoriasis pathogenesis taking into consideration role immune mechanisms relation between disease other chronic processes organism, as a result which is considered to be multimorbid condition. multimorbidity an important factor for selecting therapy, especially patients with severe forms disease.
Neurotransmitters such as neuropeptides and neurotrophins can have an effect on the development of a skin inflammatory reaction itching well condition nerve fibers. Goal. To assess expression in patients with atopic dermatitis. Materials methods. Expression substance P SP-R receptor, calcitonin gene-related peptide (CGRP) CGRP-R neurotrophin (nerve growth factor) TrkA receptor amphiregulin enhancing fibers semaphorin-3A terminating was determined dermatitis based immunohistochemistry...
Study of progression itching intensity and expression growth factor proteins in skin people suffering from atopic dermatitis under the influence narrowband (311Nm) phototherapy. Material methods. 30 patients with were treated by using SCORAD index was used to assess severity clinical responses. Itching assessed visual analogue scale. Expression nerves, semaphorine-3A, amphiregulin, PGP9.5, a protein marker for nerve fibers, investigated means indirect immunofluorescence. Results. Increased...
Today there are no ethiopathogenetic treatment methods for treating hereditary epidermolysis bullosa. All available symptomatic and mainly aimed at patient care. Since severe forms of bullosa affect multiple organs, patients need assistance both dermatologists skilled experts such as general practitioners (pediatricians), gastroenterologists dentists or ophthalmologists, surgeons, hematologists, oncologists, etc. when needed. To take efficient therapeutic preventive measures, clinical...
The authors discuss the use of confocal laser scanning microscopy in vivo (CLSM) for diagnosing melanocytic skin neoplasms and its value early diagnostics melanoma. CLSM is an innovation noninvasive visual examination method real-time multiple painless examinations patient’s without injuring integument. ensures melanomas with high sensitivity specificity, which makes it possible to screening sake onset treatment save patient life health.
Congenital epidermolysis bullosa is a group of hereditary skin diseases caused by mutations in the genes structural proteins dermoepidermal junction skin, characterized formation blisters and erosions at smallest mechanical trauma. In patients with severe subtypes borderline dystrophic there are long-term erosive ulcerative defects disruption healing process. Factors that impede include: malnutrition, anemia, pain, inactivity, local factors (presence infection, prolonged inflammation,...
Hereditary epidermolysis bullosa is a big group of hereditary diseases with the main manifestations in form blisters on skin and mucous coat after slight mechanical injuries. It not always possible to diagnose this disease based clinical picture. The article discusses current laboratory diagnostics methods for including immunofluorescence antigen mapping (IFM), transmission electron microscopy (TEM) genetic analysis (molecular or DNA diagnostics) as well their advantages disadvantages. TEM...
Atopic dermatitis is one of the most prevalent chronic inflammatory skin diseases, which can vastly influence patients quality life. Objective assessment severity required to select adequate therapy and evaluate its effectiveness. Heterogeneous clinical manifestations with greatly varying make it difficult assess atopic dermatitis. More than twenty methods are developed for this diseases severity. SCORAD, oSCORAD EASI elementary reliable allowing define relatively quickly accurately. Each...
Goal. To assess the effect of topical treatment atopic dermatitis patients with 0.1% tacrolimus ointment on itching intensity and skin expression level growth factor proteins affecting cutaneous innervation. Materials methods. Fifteen suffering from underwent ointment. The SCORAD index was calculated to severity clinical manifestations. assessed using a visual analogue scale. nerve factors, amphiregulin, semaphorin 3A PGP9.5 protein (a fiber marker) by indirect immunofluorescence method....
Epidermolysis bullosa is a group of rare hereditary skin diseases based on mutations in the genes structural proteins epidermis and dermal-epidermal junction. Clinically, epidermolysis characterized by appearance erosions blisters mucous membranes response to any minor impact. Currently, treatment only symptomatic. Pathogenetic methods therapy are under development. One new possible pathogenetic directions aminoglycoside antibiotics (gentamicin, geneticin, paromomycin). A number studies have...
Atopicheskij dermatit (AtD) — shiroko rasprostranennoe mul'tifaktornoe geneticheski determinirovannoe vospalitel'noe zabolevanie kozhi, obuslovlennoe sredi prochih prichin narusheniem funkcij epidermal'nogo bar'era. Nulevye mutacii gena filaggrina vazhnogo komponenta sistemy natural'nogo uvlazhnyayushchego faktora, privodyashchie k otsutstviyu vyrabotki polnocennogo belka-predshestvennika, associirovany s AtD. Cel' issledovaniya ocenit' chastotu naibolee rasprostranennyh v evropejskih...
The relevance of the disease is due to its prevalence ― for acute urticaria up 20% with predominance in paediatric population, chronic spontaneous 0.5–5% population. course characterised by unpredictability prognosis duration, effectiveness standard therapy, serious impact on quality life patient, his relatives, burden health authorities. lack accurate understanding mechanisms development, a wide range pathogenetic treatment complicates possibility rapid achievement drug remission. clinical...
Congenital epidermolysis bullosa is a phenotypically and genetically heterogeneous group of genodermatoses, which clinically manifested by the development blisters on skin mucous membranes after mechanical injury. The presence long-term erosive ulcerative defects in patients with congenital reduces quality patients` life also leads to malignancy lesions, as result constant stimulation regenerative processes.Currently, there are lot publications describing use substitutes, three-dimensional...
Therapy of patients with pemphigus vulgaris systemic corticosteroids may not be effective enough or lead to the development severe adverse events that make it necessary reduce dose corticosteroid. In such cases, is possible use immunosuppressants. The literature review analyzes case reports and results studies evaluated effectiveness safety drugs used for immunosuppressive therapy vulgaris. doses, design, criteria evaluating in are considered. As a result analysis, was shown non-compatarive...
The article presents a review of publishes sources on the efficacy methods such as tissue engineering and cellular transplantation autologous melanocytes for treatment vitiligo patients. describes general principles particular features current melanocyte methods.